Ferroptosis promotes T-cell activation-induced neurodegeneration in multiple sclerosis
, 2022 Jinyuan Luoqian +13 more
openalex +2 more sources
Quantification of Similar Neurodegeneration Across Geriatric Concussions and Alzheimer’s Disease [PDF]
, 2021 Andrei Irimia, Kenneth A. Rostowsky
openalex +1 more source
Neuroimaging and Neurodegeneration
Neurodegenerative Diseases, 2023 Botta, Daniele, Lövblad, Karl-Olof
openaire +3 more sources
Microglia in neurodegeneration
Nature Neuroscience, 2018 The neuroimmune system is involved in development, normal functioning, aging, and injury of the central nervous system. Microglia, first described a century ago, are the main neuroimmune cells and have three essential functions: a sentinel function involved in constant sensing of changes in their environment, a housekeeping function that promotes ...
Suzanne Hickman +4 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Introduction Progressive Supranuclear Palsy (PSP) is a neurodegenerative ‘tauopathy’ with predominating pathology in the basal ganglia and midbrain. Caudal tau spread frequently implicates the cerebellum; however, the pattern of atrophy remains equivocal.
Chloe Spiegel +8 more
wiley +1 more source
C26-Ceramide as highly sensitive biomarker for the diagnosis of Farber Disease
Scientific Reports, 2017 Farber disease (FD) is a rare autosomal recessive disease caused by mutations in the acid ceramidase gene (ASAH1). Low ceramidase activity results in the accumulation of fatty substances, mainly ceramides.
Claudia Cozma +9 more
doaj +1 more source
Cloning of the Neurodegeneration Gene \u3cem\u3eDrop-Dead\u3c/em\u3e and Characterization of Additional Phenotypes of its Mutation [PDF]
, 2008 Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd gene and its mechanism of action are not known.
Blumenthal, Edward M.
core +1 more source
Dibenzoylthiamine Has Powerful Antioxidant and Anti-Inflammatory Properties in Cultured Cells and in Mouse Models of Stress and Neurodegeneration [PDF]
, 2020 Margaux Sambon +10 more
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Macrophages and neurodegeneration
Brain Research Reviews, 2005 Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Demyelination is a classical feature of MS lesions, and neurological deficits are often ascribed to the reduced signal conduction by demyelinated axons. However, recent studies emphasize that axonal loss is an important factor in MS pathogenesis
Hendriks, Jerome J A +3 more
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Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source