Results 211 to 220 of about 300,100 (258)

Biomarker profiles in late-life depression and Alzheimer's disease across and beyond the A/T/N framework: A scoping review. [PDF]

Alzheimers Dement
Zhu Y, Damera N, Singh RK, Bekena S, Kelble L, McGuire K, Hu Y, Mersiehazen E, Vijay G, Nazif A, Kolady R, Xiang L, Liu X, Flores S, Dombrowski K, Pal S, Hardi A, Taylor K, Trani JF, Ances BM, Lenze EJ, Vemuri P, Jack CR, Petersen RC, Babulal GM.   +24 more
europepmc   +1 more source

Cerebral Hemodynamic Changes in Older Adults With Cognitive Complaints According to the Presence of Peripheral Artery Disease

AGING MEDICINE, EarlyView.
Among 132 older adults, 13 had peripheral artery disease (PAD), identified using the ankle–brachial index. Over approximately 13 months, PAD was associated with increasing middle cerebral artery mean flow velocity, with a significant difference in left‐sided velocity change between groups.
SangMi Noh, Hae‐Eun Shin, YongSoo Shim
wiley   +1 more source

Emerging roles of granzymes in neurodegeneration and neuroinflammation: mechanistic insights and therapeutic opportunities. [PDF]

Acta Neuropathol
Yoo HS, Yu P, Zhou C, Hosseini A, Granville DJ, Matsubara JA.   +5 more
europepmc   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus. [PDF]

Intensive Care Med Exp
Winzey KD, Guzman S, Yang E, Moreira D, Wang X, Gu X, Dillon ST, Ely EW, Karumanchi SA, Libermann TA, Lahiri S.   +10 more
europepmc   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Glutamatergic neuron degeneration in <i>C. elegans</i> models of Frontotemporal Dementia and Amyotrophic Lateral Sclerosis. [PDF]

MicroPubl Biol
Hassell LA, Gallati M, Thoma M, Asfaw S, Hart AC.   +4 more
europepmc   +1 more source