Results 1 to 10 of about 10,649,245 (284)
Hallmarks of neurodegenerative diseases.
Cell, 2023 Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network ...
David M. Wilson +5 more
semanticscholar +1 more source
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Signal Transduction and Targeted Therapy, 2023 Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao +3 more
semanticscholar +1 more source
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Frontiers in Aging Neuroscience, 2022 Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar +1 more source
A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
Scientific Data, 2023 Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking.
Kevin Menden +19 more
doaj +1 more source
Diseases, 2023 Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood.
Kakarla Ramakrishna +12 more
semanticscholar +1 more source
NEURODEGENERATIVE DISEASES [PDF]
Neuroimaging Clinics of North America, 2001 This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well
H H, Goebel, J, Bohl, W, Müller-Forell
openaire +3 more sources
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
International Journal of Molecular Sciences, 2022 Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen ...
D. Teleanu +8 more
semanticscholar +1 more source
Advancement of science, 2023 Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is morphologically and mechanistically different from other forms of cell death, plays a vital role in the pathophysiological process of neurodegenerative diseases ...
Yumin Wang +4 more
semanticscholar +1 more source
Advancing cell therapy for neurodegenerative diseases.
Cell Stem Cell, 2023 Cell-based therapies are being developed for various neurodegenerative diseases that affect the central nervous system (CNS). Concomitantly, the roles of individual cell types in neurodegenerative pathology are being uncovered by genetic and single-cell ...
S. Temple
semanticscholar +1 more source
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Cells, 2022 Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the
Menbere Y Wendimu, S. Hooks
semanticscholar +1 more source