Results 1 to 10 of about 581,379 (326)

A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes

Scientific Data, 2023
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking.
Kevin Menden, Margherita Francescatto, Tenzin Nyima, Cornelis Blauwendraat, Ashutosh Dhingra, Melissa Castillo-Lizardo, Noémia Fernandes, Lalit Kaurani, Deborah Kronenberg-Versteeg, Burcu Atasu, Eldem Sadikoglou, Barbara Borroni, Salvador Rodriguez-Nieto, Javier Simon-Sanchez, Andre Fischer, David Wesley Craig, Manuela Neumann, Stefan Bonn, Patrizia Rizzu, Peter Heutink   +19 more
doaj   +1 more source

NEURODEGENERATIVE DISEASES [PDF]

Neuroimaging Clinics of North America, 2001
This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well
H H, Goebel, J, Bohl, W, Müller-Forell
openaire   +3 more sources

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

npj Parkinson's Disease, 2023
Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and ...
Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha   +10 more
doaj   +1 more source

Aquaporins and Neurodegenerative Diseases [PDF]

Current Neuropharmacology, 2010
Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
openaire   +2 more sources

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Alzheimer’s Research & Therapy, 2023
Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration ...
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka, the DELCODE study group   +52 more
doaj   +1 more source

Mitoepigenetics and Neurodegenerative Diseases [PDF]

Frontiers in Endocrinology, 2019
Mitochondrial impairment and increased oxidative stress are common features in neurodegenerative disorders, leading researchers to speculate that epigenetic changes in the mitochondrial DNA (mitoepigenetics) could contribute to neurodegeneration.
Coppede F., Stoccoro A.
openaire   +3 more sources

Reactivated endogenous retroviruses promote protein aggregate spreading

Nature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg   +7 more
doaj   +1 more source

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Acta Neuropathologica Communications, 2020
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers (or strains) of
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker   +13 more
doaj   +1 more source

Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models

Stem Cell Research & Therapy, 2018
Background Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and ...
Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Revel   +16 more
doaj   +1 more source

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders).
Patrick Müller, Anne‐Katrin Vellage, Marlen Schmicker, Inga Menze, Michel J. Grothe, Stefan J. Teipel, Notger G. Müller   +6 more
doaj   +1 more source