Results 11 to 20 of about 9,535,309 (342)
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao+3 more
semanticscholar +1 more source
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood.
Kakarla Ramakrishna+12 more
semanticscholar +1 more source
Microglia Polarization From M1 to M2 in Neurodegenerative Diseases
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar +1 more source
An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen ...
D. Teleanu+8 more
semanticscholar +1 more source
A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking.
Kevin Menden+19 more
doaj +1 more source
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the
Menbere Y Wendimu, S. Hooks
semanticscholar +1 more source
Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases
Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes ...
A. Rauf+8 more
semanticscholar +1 more source
Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and ...
Amber D. Van Laar+10 more
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Reactivated endogenous retroviruses promote protein aggregate spreading
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu+7 more
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Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar +1 more source