Results 11 to 20 of about 241,511 (306)

Immunotherapies for Neurodegenerative Diseases [PDF]

Frontiers in Neurology, 2021
The current treatments for neurodegenerative diseases are mostly symptomatic without affecting the underlying cause of disease. Emerging evidence supports a potential role for immunotherapy in the management of disease progression. Numerous reports raise
Almawi, Wassim Y., Farah, Raymond, Fares, Youssef, Mortada, Ibrahim, Nabha, Sanaa, Ojcius, David M., Sadier, Najwane S.   +6 more
core   +7 more sources

Sphingolipids in Neurodegenerative Diseases [PDF]

Frontiers in Neuroscience, 2023
Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs.
Bellen, Hugo J, Dutta, Debdeep, Lu, Shenzhao, Pan, Xueyang   +3 more
core   +5 more sources

Aquaporins and Neurodegenerative Diseases [PDF]

Current Neuropharmacology, 2010
Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of ...
Foglio, Eleonora, Rodella, Luigi Fabrizio   +1 more
core   +6 more sources

Neurofilamentopathy in Neurodegenerative Diseases [PDF]

The Open Neurology Journal, 2011
Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation,
Alvarado-Diaz, Abdiel, Liu, Quan, Moreira, Paula I, Perry, George, Smith, Mark A, Xie, Fang, Zhu, Xiongwei   +6 more
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Glycoproteomics in neurodegenerative diseases [PDF]

Mass Spectrometry Reviews, 2010
Protein glycosylation regulates protein function and cellular distribution. Additionally, aberrant protein glycosylations have been recognized to play major roles in human disorders, including neurodegenerative diseases.
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Neuregulins in Neurodegenerative Diseases [PDF]

Frontiers in Aging Neuroscience, 2021
Neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal loss and neurological dysfunctions in the nervous system, affecting both memory and motor functions.
Guan-Yong Ou, Wen-Wen Lin, Weijiang Zhao, Weijiang Zhao   +3 more
openaire   +3 more sources

CXCR4 involvement in neurodegenerative diseases [PDF]

Translational Psychiatry, 2018
ABSTRACTNeurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases.
Karch, Celeste M., Wen, Natalie
core   +18 more sources

Mitoepigenetics and Neurodegenerative Diseases [PDF]

Frontiers in Endocrinology, 2019
Mitochondrial impairment and increased oxidative stress are common features in neurodegenerative disorders, leading researchers to speculate that epigenetic changes in the mitochondrial DNA (mitoepigenetics) could contribute to neurodegeneration.
Coppede F., Stoccoro A.
openaire   +3 more sources

Microglia in neurodegenerative diseases

Neural Regeneration Research, 2021
A major feature of neurodegeneration is disruption of central nervous system homeostasis, during which microglia play diverse roles. In the central nervous system, microglia serve as the first line of immune defense and function in synapse pruning, injury repair, homeostasis maintenance, and regulation of brain development through scavenging and ...
Yu Xu, Ming-Zhu Jin, Weilin Jin, Ze-Yong Yang   +3 more
openaire   +4 more sources

TREM2 in Neurodegenerative Diseases [PDF]

Molecular Neurodegeneration, 2017
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these variants conclusively demonstrates that the immune response can play an active role in the pathogenesis of NDDs.
Victoria E. von Saucken, Victoria E. von Saucken, Taylor R. Jay, Gary E. Landreth, Gary E. Landreth   +4 more
openaire   +4 more sources