Disease Knowledge Transfer across Neurodegenerative Diseases [PDF]
, 2019 We introduce Disease Knowledge Transfer (DKT), a novel technique for transferring biomarker information between related neurodegenerative diseases. DKT infers robust multimodal biomarker trajectories in rare neurodegenerative diseases even when only ...
Alexander, Daniel C. +10 more
core +4 more sources
Systemic gene delivery to the central nervous system using Adeno-associated virus
Frontiers in Molecular Neuroscience, 2014 Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders.
Mathieu eBOURDENX +7 more
doaj +1 more source
Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]
, 2020 In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong +15 more
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Neurodegenerative diseases: challenges [PDF]
Drug Delivery and Translational Research, 2011 Diseases of the aging brain—including Alzheimer’s, Parkinson’s, and Huntington’s—affect the lives of millions and pose a growing threat to public health. These diseases occur as a result of neurodegenerative processes involving the progressive loss of structure or function of neurons, including death of neurons.
openaire +2 more sources
Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins [PDF]
, 2011 Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob diseases, Gerstmann-Str$\ddot{a}$ussler ...
Zhang, Jiapu
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The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources
Trials, 2019 Background A system of dementia-specific case conferences (WELCOME-IdA) was evaluated using a stepped-wedge design in six nursing homes (NHs) to enable nursing staff to analyse properly the behavioural and psychological symptoms (BPSD) of residents with ...
Daniela Holle +6 more
doaj +1 more source
Scientific Reports, 2022 Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten +3 more
doaj +1 more source
Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]
, 2010 Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai +4 more
core +1 more source
Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
EMBO Molecular Medicine, 2019 Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood.
Nicole Reichenbach +7 more
doaj +1 more source