Results 11 to 20 of about 9,535,309 (342)

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

open access: yesSignal Transduction and Targeted Therapy, 2023
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity.
Chao Gao   +3 more
semanticscholar   +1 more source

WNT-β Catenin Signaling as a Potential Therapeutic Target for Neurodegenerative Diseases: Current Status and Future Perspective

open access: yesDiseases, 2023
Wnt/β-catenin (WβC) signaling pathway is an important signaling pathway for the maintenance of cellular homeostasis from the embryonic developmental stages to adulthood.
Kakarla Ramakrishna   +12 more
semanticscholar   +1 more source

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

open access: yesFrontiers in Aging Neuroscience, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar   +1 more source

An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases

open access: yesInternational Journal of Molecular Sciences, 2022
Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen ...
D. Teleanu   +8 more
semanticscholar   +1 more source

A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes

open access: yesScientific Data, 2023
Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking.
Kevin Menden   +19 more
doaj   +1 more source

Microglia Phenotypes in Aging and Neurodegenerative Diseases

open access: yesCells, 2022
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the
Menbere Y Wendimu, S. Hooks
semanticscholar   +1 more source

Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases

open access: yesMolecules, 2022
Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes ...
A. Rauf   +8 more
semanticscholar   +1 more source

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

open access: yesnpj Parkinson's Disease, 2023
Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and ...
Amber D. Van Laar   +10 more
doaj   +1 more source

Reactivated endogenous retroviruses promote protein aggregate spreading

open access: yesNature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu   +7 more
doaj   +1 more source

Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

open access: yesInternational Journal of Molecular Sciences, 2022
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar   +1 more source

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