Results 21 to 30 of about 581,379 (326)

TALKING TIME: A pilot randomized controlled trial investigating social support for informal caregivers via the telephone

BMC Health Services Research, 2020
Background Caring for people with dementia at home requires considerable time, organization and commitment. Therefore, informal caregivers of people with dementia are often overburdened. This study examined the effects of the telephone-based Talking Time
Martin Nikolaus Dichter, Bernd Albers, Diana Trutschel, Armin Michael Ströbel, Swantje Seismann-Petersen, Katharina Wermke, Margareta Halek, Martin Berwig   +7 more
doaj   +1 more source

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

EMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy, Raffaella Rusconi, Blanca I. Pérez‐Revuelta, Ruth E. Musgrove, Michael Helwig, Bettina Winzen‐Reichert, Donato A. Di Monte   +6 more
doaj   +1 more source

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Nature Communications, 2023
GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden, Maria Jose Perez, Hariam Raji, Federico Bertoli, Stefanie Kalb, María Illescas, Fokion Spanos, Claudio Giuliano, Alessandra Maria Calogero, Marvin Oldrati, Hannah Hebestreit, Graziella Cappelletti, Kathrin Brockmann, Thomas Gasser, Anthony H. V. Schapira, Cristina Ugalde, Michela Deleidi   +16 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Exploring the ATN classification system using brain morphology

Alzheimer’s Research & Therapy, 2023
Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler, for the Alzheimer’s Disease Neuroimaging Initiative   +42 more
doaj   +1 more source

Neurodegenerative Diseases and Autophagy [PDF]

, 2018
Most neurodegenerative diseases are characterized by the accumulation of aggregated proteins within neurons. These aggregate-prone proteins cause toxicity, a phenomenon that is further exacerbated when there is defective protein clearance.
Aflaki, Aflaki, Aguado, Aguib, Akizu, Al-Saif, Alves, Ando, Ando, Andrew, Argov, Argov, Arrasate, Ashkenazi, Axe, Ballabio, Belzil, Benjamin, Bento, Berger, Bernhardt, Biazik, Bitoun, Bjorkoy, Blanz, Blommaart, Boland, Bouhouche, Bryceson, Butzlaff, Byrne, Caccamo, Caccamo, Caccamo, Cadwell, Castillo, Castillo, Cataldo, Cataldo, Chan, Chang, Chen, Chen, Chen, Cheroni, Chesser, Chung, Cirulli, Citron, Coffey, Colacurcio, Conner, Corcelle-Termeau, Cortes, Cortes, Criado, Cullup, Cunha-Santos, Cunningham, Daud, Davies, de Duve, DeBosch, Decressac, Dehay, DeJesus-Hernandez, del Campo, Deng, Deretic, DeSelm, Di Bartolomeo, Dierks, Dionisi Vici, Dooley, Dowdle, Dressel, Du, Duran, Durcan, Durcan, Durieux, Egan, Eisenberg, Eisenberg, Emanuele, Endo, Fader, Fang, Farg, Farrer, Fecto, Fernandes, Filimonenko, Fink, Fleming, Fraldi, Freischmidt, Fujita, Fullgrabe, Furuta, Gal, Ganley, Ganley, Gatchel, Gautam, Ge, Ge, Ghavidel, Goedert, Goedert, Gomez-Sanchez, Goode, Graef, Haack, Hadano, Hamacher-Brady, Hamasaki, Hansen, Hara, Harms, Harris, Hawkins-Salsbury, Hayashi-Nishino, Heitman, Heo, Hirst, Hong, Hosokawa, Hsieh, Huang, Huett, Huotari, Ichimura, Itakura, Jaeger, Jahn, Jang, Jang, Jiang, Jung, Kamiya, Kane, Kaneb, Karanasios, Kaushik, Kazlauskaite, Kett, Khaminets, Khaminets, Khurana, Kim, Kim, Kim, Kim, Kimura, Kimura, Kirkin, Kitada, Knaevelsrud, Knorr, Komatsu, Komatsu, Komatsu, Komatsu, Kondapalli, Koyano, Kraft, Krasniak, Kruger, Kuma, Kyttala, Labuzek, Lacovich, Lamb, Laplante, Lazarou, Lee, Lee, Lee, Lee, Lee, Levine, Li, Li, Liang, Lin, Liu, Liu, Liu, Lloyd-Evans, Lloyd-Evans, Longatti, Lonskaya, Lonskaya, Lopez, Lopez de Maturana, Lu, Lu, Lunemann, Luty, Luzio, Lv, Ma, Ma, Magalhaes, Majid, Mancias, Mandell, Manzanillo, Marshall, Martinez-Vicente, Maruyama, Matikainen-Ankney, Mawuenyega, Mayer, Mazzulli, Mazzulli, McWilliams, Mealer, Medina, Melser, Menzies, Menzies, Menzies, Michaud, Millecamps, Minassian, Mizuno, Mizushima, Mizushima, Mizushima, Mochida, Moore, Moreau, Moreau, Morimoto, Murphy, Murray, Myeku, Nakatogawa, Narang, Narendra, Nascimento-Ferreira, Nazio, Newman, Nguyen, Nilsson, Nishiyama, Nixon, Nixon, Noda, Onofre, Ordureau, Orsi, Oz-Levi, Ozcelik, Pacheco, Palikaras, Pankiv, Papinski, Park, Park, Pavel, Perez, Pickford, Pickrell, Pilli, Piras, Platt, Potter, Poupetova, Proikas-Cezanne, Pryor, Puls, Puri, Pyo, Ramesh Babu, Randow, Ravikumar, Ravikumar, Ravikumar, Ravikumar, Ravikumar, Razi, Reinwald, Renvoise, Richards, Rockenstein, Roczniak-Ferguson, Rodriguez-Navarro, Rogov, Rohn, Roosen, Rose, Rubinsztein, Rubinsztein, Rui, Russell, Rusten, Saftig, Sahu, Saitsu, Sanchez-Martinez, Sandoval, Sanjuan, Sano, Sardiello, Sarkar, Sarkar, Sato, Schaeffer, Schreiber, Schroder, Sellier, Seok, Serrano-Puebla, Settembre, Settembre, Settembre, Shaid, Shen, Shibata, Shibutani, Siddiqi, Siddiqui, Simonsen, Singh, Small, Son, Sorbara, Sou, Spampanato, Spilman, Staats, Stadel, Sun, Sundaramoorthy, Svenning, Tan, Tanaka, Tang, Tanji, Teyssou, Thurston, Tian, Tian, Tiede, Tien, Tsuboyama, Tsunemi, Tumbarello, Ugolino, Ulgherait, Ushio, Valente, Vantaggiato, Varga, Velikkakath, Vidoni, Vingtdeux, Vollrath, Wang, Wang, Wang, Watabe, Webb, Webster, Weedon, Wei, West, Wild, Williams, Williams, Winklhofer, Winslow, Wolfe, Wong, Wraith, Wu, Xi, Yamamoto, Yazdankhah, Yla-Anttila, Yoshii, Yu, Yu, Yu, Yuan, Yue, Zare-Shahabadi, Zavodszky, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zheng, Zhou, Zhou, Zuchner   +401 more
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Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases [PDF]

, 2009
Neurons are metabolically active cells with high energy demands at locations distant from the cell body. As a result, these cells are particularly dependent on mitochondrial function, as reflected by the observation that diseases of mitochondrial ...
Alexander, Baloyannis, Banchs, Bossy-Wetzel, Brockmann, Cassidy-Stone, Chang, Chen, Cho, Clark, D. C. Chan, de Brito, Delettre, Dodson, Exner, Fransson, Frezza, Gispert, H. Chen, Hollenbeck, Kim, Kim, Li, Liot, Lustbader, Macaskill, Meeusen, Milone, Mortiboys, Okamoto, Orr, Park, Parone, Popp, Reis, Suen, Ten Dijke, Trushina, Wang, Waterham, Wood-Kaczmar, Zuchner, Z  chner   +42 more
core   +3 more sources

Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine.
Martin Dyrba, Moritz Hanzig, Slawek Altenstein, Sebastian Bader, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Daniel Cantré, Peter Dechent, Laura Dobisch, Emrah Düzel, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, John-Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Deniz B. Keles, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Björn H. Schott, Annika Spottke, Eike J. Spruth, Marc-André Weber, Birgit Ertl-Wagner, Michael Wagner, Jens Wiltfang, Frank Jessen, Stefan J. Teipel, for the ADNI, AIBL, DELCODE study groups   +40 more
doaj   +1 more source

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

Molecular Neurodegeneration, 2020
Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism ...
Senthilvelrajan Kaniyappan, Katharina Tepper, Jacek Biernat, Ram Reddy Chandupatla, Sabrina Hübschmann, Stephan Irsen, Sandra Bicher, Christoph Klatt, Eva-Maria Mandelkow, Eckhard Mandelkow   +9 more
doaj   +1 more source

Biomedical Informatics Applications for Precision Management of Neurodegenerative Diseases [PDF]

, 2018
Modern medicine is in the midst of a revolution driven by “big data,” rapidly advancing computing power, and broader integration of technology into healthcare. Highly detailed and individualized profiles of both health and disease states are now possible,
Jimenez-Maggoria, Gustavo, Lombardo, Joseph, Miller, Justin B., Shan, Guogen   +3 more
core   +2 more sources