Results 21 to 30 of about 9,496,868 (341)

Microglia Polarization From M1 to M2 in Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2022
Microglia-mediated neuroinflammation is a common feature of neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS).
Shenrui Guo, Hui Wang, Yafu Yin
semanticscholar   +1 more source

Sphingolipids in neurodegenerative diseases

Frontiers in Neuroscience, 2023
Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is affected in a surprisingly broad set of NDDs. These include some lysosomal storage diseases (LSDs), hereditary sensory and autonomous neuropathy (HSAN), hereditary spastic paraplegia ...
Xueyang Pan, Xueyang Pan, Debdeep Dutta, Debdeep Dutta, Shenzhao Lu, Shenzhao Lu, Hugo J. Bellen, Hugo J. Bellen, Hugo J. Bellen   +8 more
openaire   +4 more sources

Aquaporins and Neurodegenerative Diseases [PDF]

Current Neuropharmacology, 2010
Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
openaire   +3 more sources

Microglia in neurodegenerative diseases

Neural Regeneration Research, 2021
A major feature of neurodegeneration is disruption of central nervous system homeostasis, during which microglia play diverse roles. In the central nervous system, microglia serve as the first line of immune defense and function in synapse pruning, injury repair, homeostasis maintenance, and regulation of brain development through scavenging and ...
Yu Xu, Ming-Zhu Jin, Weilin Jin, Ze-Yong Yang   +3 more
openaire   +4 more sources

TREM2 in Neurodegenerative Diseases [PDF]

Molecular Neurodegeneration, 2017
TREM2 variants have been identified as risk factors for Alzheimer's disease (AD) and other neurodegenerative diseases (NDDs). Because TREM2 encodes a receptor exclusively expressed on immune cells, identification of these variants conclusively demonstrates that the immune response can play an active role in the pathogenesis of NDDs.
Victoria E. von Saucken, Victoria E. von Saucken, Taylor R. Jay, Gary E. Landreth, Gary E. Landreth   +4 more
openaire   +4 more sources

Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study

Alzheimer’s Research & Therapy, 2023
Background Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration ...
Frederic Brosseron, Anne Maass, Luca Kleineidam, Kishore Aravind Ravichandran, Carl-Christian Kolbe, Steffen Wolfsgruber, Francesco Santarelli, Lisa M. Häsler, Róisín McManus, Christina Ising, Sandra Röske, Oliver Peters, Nicoleta-Carmen Cosma, Luisa-Sophie Schneider, Xiao Wang, Josef Priller, Eike J. Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Björn H. Schott, Katharina Buerger, Daniel Janowitz, Martin Dichgans, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Doreen Görß, Christoph Laske, Matthias H. Munk, Emrah Düzel, Renat Yakupow, Laura Dobisch, Coraline D. Metzger, Wenzel Glanz, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Nina Roy, Ayda Rostamzadeh, Annika Spottke, Alfredo Ramirez, David Mengel, Matthis Synofzik, Mathias Jucker, Eicke Latz, Frank Jessen, Michael Wagner, Michael T. Heneka, the DELCODE study group   +52 more
doaj   +1 more source

Microglia Phenotypes in Aging and Neurodegenerative Diseases

Cells, 2022
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a fundamental role in mediating the onset and progression of disease. Microglia, which function as first-line immune guardians of the central nervous system (CNS), are the
Menbere Y Wendimu, S. Hooks
semanticscholar   +1 more source

Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy

npj Parkinson's Disease, 2023
Individuals with Parkinson’s disease (PD) typically receive a diagnosis once they have developed motor symptoms, at which point there is already significant loss of substantia nigra dopamine neurons, α-synuclein accumulation in surviving neurons, and ...
Amber D. Van Laar, Katherine R. Webb, Matthew T. Keeney, Victor S. Van Laar, Alevtina Zharikov, Edward A. Burton, Teresa G. Hastings, Kelly E. Glajch, Warren D. Hirst, J. Timothy Greenamyre, Emily M. Rocha   +10 more
doaj   +1 more source

Neuroinflammatory Markers: Key Indicators in the Pathology of Neurodegenerative Diseases

Molecules, 2022
Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of neurodegenerative diseases. The CNS is composed of neurons and glial cells consisting of microglia, oligodendrocytes, and astrocytes ...
A. Rauf, Himani Badoni, Tareq Abu-Izneid, A. Olatunde, M. Rahman, Sakshi Painuli, Prabhakar Semwal, P. Wilairatana, Mohammad S. Mubarak   +8 more
semanticscholar   +1 more source

Reactivated endogenous retroviruses promote protein aggregate spreading

Nature Communications, 2023
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved.
Shu Liu, Stefanie-Elisabeth Heumüller, André Hossinger, Stephan A. Müller, Oleksandra Buravlova, Stefan F. Lichtenthaler, Philip Denner, Ina M. Vorberg   +7 more
doaj   +1 more source