Results 291 to 300 of about 9,268,601 (369)

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Novel blood-based proteomic signatures across multiple neurodegenerative diseases. [PDF]

Alzheimers Dement
Durcan R, Heslegrave A, Swann P, Goddard J, Chouliaras L, Murley AG, Savulich G, Bevan-Jones WR, Swann O, Ashton NJ, Blennow K, McEwan W, Zetterberg H, Rowe JB, O'Brien JT, Malpetti M.   +15 more
europepmc   +1 more source

MEA‐seqX: High‐Resolution Profiling of Large‐Scale Electrophysiological and Transcriptional Network Dynamics

Advanced Science, EarlyView.
How can we fully understand brain function and disease without uncovering the causal coordination between molecular and neural activity across space and time? MEA‐seqX tackles this challenge by integrating advanced electrophysiology, spatial transcriptomics, and artificial intelligence predictions, revealing multiscale dynamics.
Brett Addison Emery, Xin Hu, Diana Klütsch, Shahrukh Khanzada, Ludvig Larsson, Ionut Dumitru, Jonas Frisén, Joakim Lundeberg, Gerd Kempermann, Hayder Amin   +9 more
wiley   +1 more source

Natural products in neurodegenerative diseases: recent advances and future outlook. [PDF]

Front Pharmacol
Nahar L, Charoensup R, Kalieva K, Habibi E, Guo M, Wang D, Kvasnica M, Onder A, Sarker SD.   +8 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Role of iron in brain development, aging, and neurodegenerative diseases. [PDF]

Ann Med
Gao Q, Zhou Y, Chen Y, Hu W, Jin W, Zhou C, Yuan H, Li J, Lin Z, Lin W.   +9 more
europepmc   +1 more source

Abstracts from the 1st International Conference on Alzheimer's disease and Related Neurodegenerative Disorders Wuhan, China

, 2002
Khalid Iqbal, Alejandra del C. Alonso, Chang Gong, Niloufar Haque, S. Khatoon, Juan Pei, A. Sengupta, Ichiro Tsujio, Jiebiao Wang, Inge Grundke‐Iqbal, Mamoru Takeda, George Perry, Rudolph J. Castellani, Peggy L.R. Harris, Sandra L. Siedlak, Mariarosaria Taddeo, Akihiko Nunomura, Hisashi Fujioka, Mark A. Smith, Abha Chauhan, Ved Chauhan   +20 more
openalex   +2 more sources

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

Nature Neuroscience, 2018
C. Soto, S. Pritzkow
semanticscholar   +1 more source

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

Advanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang   +5 more
wiley   +1 more source