Results 31 to 40 of about 9,301,430 (292)
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources
Systemic gene delivery to the central nervous system using Adeno-associated virus
Frontiers in Molecular Neuroscience, 2014 Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders.
Mathieu eBOURDENX +7 more
doaj +1 more source
Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
Science, 2021 Description Disease and hippocampal disfunction Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment.
J. Terreros-Roncal +7 more
semanticscholar +1 more source
Regulation of Mitochondrial Dynamics and Neurodegenerative Diseases [PDF]
, 2011 Mitochondria are important cellular organelles in most metabolic processes and have a highly dynamic nature, undergoing frequent fission and fusion. The dynamic balance between fission and fusion plays critical roles in mitochondrial functions. In recent
Fujimura, Atsushi +6 more
core +1 more source
International Journal of Molecular Sciences, 2021 Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that
Łucja Justyna Walczak-Nowicka +1 more
semanticscholar +1 more source
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation [PDF]
, 2019 Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies.
Codocedo, Juan F. +3 more
core +1 more source
Scientific Reports, 2022 Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten +3 more
doaj +1 more source
Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
Cell & Bioscience, 2020 The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis.
Fei Xu, Lixin Na, Yanfei Li, Linjun Chen
semanticscholar +1 more source
Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation.
Farzane Sivandzade, L. Cucullo
semanticscholar +1 more source
The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]
, 2012 A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L. +1 more
core +3 more sources