Results 31 to 40 of about 9,496,868 (341)

Proteotoxicity and Neurodegenerative Diseases [PDF]

International Journal of Molecular Sciences, 2020
Neurodegenerative diseases are a major burden for our society, affecting millions of people worldwide. A main goal of past and current research is to enhance our understanding of the mechanisms underlying proteotoxicity, a common theme among these incurable and debilitating conditions.
Jose Luis Alcantud, Raquel Duran, Sara Bandres-Ciga, Francisco Montero, Clara Ruz   +4 more
openaire   +3 more sources

Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions

Acta Neuropathologica Communications, 2020
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought to be attributed to conformers (or strains) of
Gaye Tanriöver, Mehtap Bacioglu, Manuel Schweighauser, Jasmin Mahler, Bettina M. Wegenast-Braun, Angelos Skodras, Ulrike Obermüller, Melanie Barth, Deborah Kronenberg-Versteeg, K. Peter R. Nilsson, Derya R. Shimshek, Philipp J. Kahle, Yvonne S. Eisele, Mathias Jucker   +13 more
doaj   +1 more source

Structural MRI of the basal forebrain as predictor of cognitive response to galantamine in healthy older adults—A randomized controlled double‐blinded crossover study

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction Cholinesterase inhibitors can enhance cognitive functions in healthy elderly and delay cognitive decline in patients with Alzheimer`s disease (AD). However, not everyone benefits from this treatment (non‐responders).
Patrick Müller, Anne‐Katrin Vellage, Marlen Schmicker, Inga Menze, Michel J. Grothe, Stefan J. Teipel, Notger G. Müller   +6 more
doaj   +1 more source

Recent Advances on the Role of Brain-Derived Neurotrophic Factor (BDNF) in Neurodegenerative Diseases

International Journal of Molecular Sciences, 2022
Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are essential for neuronal survival and growth. The signaling cascades initiated by BDNF and its receptor are the key regulators of synaptic plasticity, which plays important role in ...
Khairunnuur Fairuz Azman, R. Zakaria
semanticscholar   +1 more source

Epilepsy in neurodegenerative diseases [PDF]

Epileptic Disorders, 2022
AbstractAlthough epilepsy as a comorbidity in neurodegenerative disorders is increasingly recognized, its incidence is still underestimated and the features of epilepsy in the different neurodegenerative conditions are still poorly defined. Improved health care, resulting in increased longevity, will unavoidably lead to an increment of epilepsy cases ...
Neri, Sabrina, Mastroianni, Giovanni, Gardella, Elena, Aguglia, Umberto, Rubboli, Guido   +4 more
openaire   +3 more sources

Shared mechanisms across the major psychiatric and neurodegenerative diseases

Nature Communications, 2022
Several common psychiatric and neurodegenerative diseases share epidemiologic risk; however, whether they share pathophysiology is unclear and is the focus of our investigation.
T. Wingo, Yue Liu, E. Gerasimov, Selina M. Vattathil, Meghan E. Wynne, Jiaqi Liu, A. Lori, V. Faundez, David A. Bennett, N. Seyfried, A. Levey, A. Wingo   +11 more
semanticscholar   +1 more source

Safety and efficacy of human embryonic stem cell-derived astrocytes following intrathecal transplantation in SOD1G93A and NSG animal models

Stem Cell Research & Therapy, 2018
Background Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and ...
Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath, Michel Revel   +16 more
doaj   +1 more source

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Nature Communications, 2021
Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases.
Wei Feng, Xiuguo Han, Hui Hu, Meiqi Chang, Li Ding, Huijing Xiang, Yu Chen, Yuehua Li   +7 more
semanticscholar   +1 more source

Mitophagy in neurodegenerative diseases [PDF]

Neurochemistry International, 2018
Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS), are a complex "family" of pathologies, characterised by the progressive loss of neurons and/or neuronal functions, leading to severe physical and cognitive inabilities in affected patients.
Francesco Cecconi, Francesco Cecconi, Silvia Campello, Carlo Rodolfo   +3 more
openaire   +4 more sources

Systemic gene delivery to the central nervous system using Adeno-associated virus

Frontiers in Molecular Neuroscience, 2014
Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders.
Mathieu eBOURDENX, Mathieu eBOURDENX, Nathalie eDUTHEIL, Nathalie eDUTHEIL, Erwan eBEZARD, Erwan eBEZARD, Benjamin eDEHAY, Benjamin eDEHAY   +7 more
doaj   +1 more source