Results 41 to 50 of about 9,301,430 (292)

Process evaluation of the context, reach and recruitment of participants and delivery of dementia-specific case conferences (WELCOME-IdA) in nursing homes (FallDem): a mixed-methods study

Trials, 2019
Background A system of dementia-specific case conferences (WELCOME-IdA) was evaluated using a stepped-wedge design in six nursing homes (NHs) to enable nursing staff to analyse properly the behavioural and psychological symptoms (BPSD) of residents with ...
Daniela Holle, Rene Müller-Widmer, Sven Reuther, Ute Rosier-Segschneider, Rabea Graf, Martina Roes, Margareta Halek   +6 more
doaj   +1 more source

Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism

Nature Communications, 2023
GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden, Maria Jose Perez, Hariam Raji, Federico Bertoli, Stefanie Kalb, María Illescas, Fokion Spanos, Claudio Giuliano, Alessandra Maria Calogero, Marvin Oldrati, Hannah Hebestreit, Graziella Cappelletti, Kathrin Brockmann, Thomas Gasser, Anthony H. V. Schapira, Cristina Ugalde, Michela Deleidi   +16 more
doaj   +1 more source

Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases

Frontiers in Neuroscience, 2020
Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to
Xiaohua Song, Dingxin Long
semanticscholar   +1 more source

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Frontiers in Pharmacology, 2021
Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins.
R. Manjula, K. Anuja, F. Alcaín
semanticscholar   +1 more source

TALKING TIME: A pilot randomized controlled trial investigating social support for informal caregivers via the telephone

BMC Health Services Research, 2020
Background Caring for people with dementia at home requires considerable time, organization and commitment. Therefore, informal caregivers of people with dementia are often overburdened. This study examined the effects of the telephone-based Talking Time
Martin Nikolaus Dichter, Bernd Albers, Diana Trutschel, Armin Michael Ströbel, Swantje Seismann-Petersen, Katharina Wermke, Margareta Halek, Martin Berwig   +7 more
doaj   +1 more source

Exploring the ATN classification system using brain morphology

Alzheimer’s Research & Therapy, 2023
Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger, Anne Maass, David Berron, Renat Yakupov, Oliver Peters, Jochen Fiebach, Kersten Villringer, Lukas Preis, Josef Priller, Eike Jacob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Claudia Bartels, Frank Jessen, Franziska Maier, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Killimann, Doreen Göerß, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Laura Dobisch, Michael Ewers, Peter Dechent, John Dylan Haynes, Klaus Scheffler, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Emrah Düzel, Gabriel Ziegler, for the Alzheimer’s Disease Neuroimaging Initiative   +42 more
doaj   +1 more source

Astrocytes: a double-edged sword in neurodegenerative diseases

Neural Regeneration Research, 2021
Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects.
Z. Ding, L. Song, Qing Wang, Gajendra Kumar, Yung Yan, Cun-Gen Ma   +5 more
semanticscholar   +1 more source

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

EMBO Molecular Medicine, 2019
Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood.
Nicole Reichenbach, Andrea Delekate, Monika Plescher, Franziska Schmitt, Sybille Krauss, Nelli Blank, Annett Halle, Gabor C Petzold   +7 more
doaj   +1 more source

Human Gait Analysis in Neurodegenerative Diseases: A Review

IEEE journal of biomedical and health informatics, 2021
This paper reviews the recent literature on technologies and methodologies for quantitative human gait analysis in the context of neurodegenerative diseases.
G. Cicirelli, D. Impedovo, Vincenzo Dentamaro, R. Marani, G. Pirlo, T. D’orazio   +5 more
semanticscholar   +1 more source