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Impact of neurodegenerative diseases on human adult hippocampal neurogenesis
Science, 2021 Description Disease and hippocampal disfunction Impaired function of the brain’s hippocampus can underpin psychiatric symptoms and cognitive impairment.
J. Terreros-Roncal +7 more
semanticscholar +1 more source
Stem Cell Research & Therapy, 2018 Background Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary movements, become paralyzed and ...
Michal Izrael +16 more
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Molecules, 2020 Anthocyanins are a class of water-soluble flavonoids widely present in fruits and vegetables. Dietary sources of anthocyanins include red and purple berries, grapes, apples, plums, cabbage, or foods containing high levels of natural colorants.
Roberto Mattioli +3 more
semanticscholar +1 more source
International Journal of Molecular Sciences, 2021 Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that
Łucja Justyna Walczak-Nowicka +1 more
semanticscholar +1 more source
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to
Xiaohua Song, Dingxin Long
semanticscholar +1 more source
Systemic gene delivery to the central nervous system using Adeno-associated virus
Frontiers in Molecular Neuroscience, 2014 Adeno-associated virus (AAV)-mediated gene delivery has emerged as an effective and safe tool for both preclinical and clinical studies of neurological disorders.
Mathieu eBOURDENX +7 more
doaj +1 more source
Scientific Reports, 2022 Most current models of recognition memory fail to separately model item and person heterogeneity which makes it difficult to assess ability at the latent construct level and prevents the administration of adaptive tests.
Jeremie Güsten +3 more
doaj +1 more source
Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]
, 2019 Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed +3 more
core +2 more sources
Mitophagy in neurodegenerative diseases [PDF]
Neurochemistry International, 2018 Neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD), Huntington's disease (HD), and Amyotrophic Lateral Sclerosis (ALS), are a complex "family" of pathologies, characterised by the progressive loss of neurons and/or neuronal functions, leading to severe physical and cognitive inabilities in affected patients.
Francesco Cecconi +3 more
openaire +4 more sources
Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation.
Farzane Sivandzade, L. Cucullo
semanticscholar +1 more source