Results 41 to 50 of about 9,268,601 (369)
Roles of the PI3K/AKT/mTOR signalling pathways in neurodegenerative diseases and tumours
Cell & Bioscience, 2020 The PI3 K/AKT/mTOR signalling pathway plays an important role in the regulation of signal transduction and biological processes such as cell proliferation, apoptosis, metabolism and angiogenesis.
Fei Xu, Lixin Na, Yanfei Li, Linjun Chen
semanticscholar +1 more source
Peroxiredoxins in Neurodegenerative Diseases [PDF]
Antioxidants, 2020 Substantial evidence indicates that oxidative/nitrosative stress contributes to the neurodegenerative diseases. Peroxiredoxins (PRDXs) are one of the enzymatic antioxidant mechanisms neutralizing reactive oxygen/nitrogen species. Since mammalian PRDXs were identified 30 years ago, their significance was long overshadowed by the other well-studied ROS ...
openaire +3 more sources
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to
Xiaohua Song, Dingxin Long
semanticscholar +1 more source
Regenerative Stem Cell Therapy for Neurodegenerative Diseases: An Overview
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases resulting from the progressive loss of structure and/or function of neurons contribute to different paralysis degrees and loss of cognition and sensation.
Farzane Sivandzade, L. Cucullo
semanticscholar +1 more source
Synapses in neurodegenerative diseases [PDF]
BMB Reports, 2017 Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow.
Sung-Hoon Kim, Bae
openaire +3 more sources
Advances in Neurodegenerative Diseases
Journal of Clinical Medicine, 2023 Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population [...]
Jeroen Van Schependom +1 more
openaire +2 more sources
Trials, 2019 Background A system of dementia-specific case conferences (WELCOME-IdA) was evaluated using a stepped-wedge design in six nursing homes (NHs) to enable nursing staff to analyse properly the behavioural and psychological symptoms (BPSD) of residents with ...
Daniela Holle +6 more
doaj +1 more source
Nature Communications, 2023 GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden +16 more
doaj +1 more source
Exploring the ATN classification system using brain morphology
Alzheimer’s Research & Therapy, 2023 Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger +42 more
doaj +1 more source