Results 101 to 110 of about 35,812 (218)

Biochemical profiling and symptomatology of androgen deficiency in males with cluster headache: A prospective case–control study

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber, Roemer B. Brandt, Mariël Leon Morales‐Grooters, Ronald van der Wal, Sjoerd A. A. van den Berg, Jelle J. Goeman, Antoinette Maassen van den Brink, Rolf Fronczek   +7 more
wiley   +1 more source

CDC7 is a targetable regulator of advanced prostate cancer

Scientific Reports
Prostate cancer is estimated to contribute to over 35,000 deaths of men residing in the United States, with the majority fatality due to metastatic disease.
Alifiani B. Hartono, HyeonJi Hwang, Sidharth Paparaju, Shiqin Liu, James D. Brooks, Eva Corey, Tanya Stoyanova   +6 more
doaj   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, EarlyView.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

The role of transcription factors in prostate cancer progression

Molecules and Cells
: Prostate cancer is one of the most common malignancies in men, with most cases initially responding to androgen deprivation therapy. However, a significant number of patients eventually develop castration-resistant prostate cancer, an aggressive form ...
Jongeun Lee, Yoontae Lee
doaj   +1 more source

Pathologic Characterization and Clinical Significance of Lymphovascular Invasion in Canine Thyroid Carcinomas

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT The association between lymphovascular invasion (LVI) and outcomes in dogs with thyroid carcinoma is inadequately described, and a standardized definition of LVI is lacking. This study's objectives were to histopathologically and immunohistochemically characterize LVI and to evaluate associated clinical outcomes in dogs with thyroid carcinoma.
Maureen A. Griffin, Brianna Stoyle, Allie Oakes, Brian Flesner, Jennifer A. Lenz, Darko Stefanovski, Amy C. Durham   +6 more
wiley   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Multi‐Vendor and Multi‐Site Characterization of 13C Coils for Clinical Studies

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2885-2893, December 2026.
ABSTRACT Purpose Due to the inherently low signal‐to‐noise ratio (SNR) domain for 13C imaging, optimal coil performance is essential to maximize data quality. Quality control (QC) for 13C coils employed in magnetic resonance spectroscopy (MRS) is of paramount importance.
Emil S. Christensen, Andreas Clemmensen, Esben S. S. Hansen, Jonathan Birchall, Mary A. McLean, Christoffer Laustsen, Andreas Kjaer, Thomas L. Andersen   +7 more
wiley   +1 more source

Renal Neuroendocrine Tumor Mimicking Upper Tract Urothelial Carcinoma

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Renal pelvic or peripelvic neuroendocrine tumors are rare and may radiologically mimic invasive upper tract urothelial carcinoma. Case Presentation A man in his 70s presented with two episodes of painless gross hematuria and lower urinary tract symptoms from benign prostatic hyperplasia.
Jia‐Yuh Sheu, Yun‐Sheng Wu, Jeff S. Chueh   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, Volume 600, Issue 19, Page 2850-2873, October 2026.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source