Results 181 to 190 of about 35,812 (218)

Current and Emerging Therapies for Neuroendocrine Prostate Cancer

SSRN Electronic Journal, 2022
Neuroendocrine prostate cancer is a histological variant of prostate cancer that is characterized by aggressiveness, poor clinical outcomes, and expression of neuroendocrine markers. Neuroendocrine prostate cancer usually manifests in late-stage prostate cancer patients who have undergone multiple rounds of anti-androgen therapies but can, although ...
Busola Ruth, Alabi, Shiqin, Liu, Tanya, Stoyanova   +2 more
openaire   +2 more sources

Neuroendocrine Differentiation in Prostate Cancer

2013
Neuroendocrine differentiation (ND) is widely observed in prostate cancer (PC). Its role in clinical practice is controversial, but preclinical and clinical evidences underline the association of ND with poor prognosis in PC patients. Neuroendocrine (NE) cells could condition the PC progression, mainly stimulating the PC exocrine neoplastic cells ...
FRANCO, Renato, CHIEFFI, Paolo, PERDONA' S, FACCHINI G, CARAGLIA, Michele   +4 more
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Role of Neuroendocrine Cells in Prostate Cancer Progression

Urologia Journal, 2011
Neuroendocrine (NE) cells represent the third epithelial cell type on normal prostatic tissue (in addition to basal and secretory cells). They are localized in all regions of the human prostate at birth but rapidly decrease in the peripheral prostate after birth, and then reappear at puberty.
SCIARRA, Alessandro, INNOCENZI, MICHELE, Michele Ravaziol, MINISOLA, FRANCESCO, ALFARONE, ANDREA, CATTARINO, SUSANNA, PANEBIANCO, VALERIA, BUONOCORE, VALERIA, GENTILE, Vincenzo, DI SILVERIO, Franco   +9 more
openaire   +3 more sources

[Neuroendocrine cancers of the prostate].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie, 1993
This article is a transcription of several papers on neuroendocrine cancers of the prostate presented to the Uropathology Club in Angers in 1990. It consists of three parts: Firstly, a study of neuroendocrine cells in various organs of the human body, followed by the demonstration of these cells in the normal and pathological prostate.
V, Lépinard, M C, Dauge-Geffroy, V, Delmas, G, Bertrand, A, Fondimare, F, Fetissof   +5 more
openaire   +1 more source

[Neuroendocrine prostate cancer].

Der Pathologe, 2018
Neuroendocrine prostate cancer (NEPC) mostly occurs as a treatment-emergent adaptive response under the pressure of intensive androgen deprivation treatment (t-NEPC). Approximately 30-40% of patients with metastatic castration-resistant prostate cancer (mCRPC) also have neuroendocrine involvement.
S, Tritschler, R, Erdelkamp, C, Stief, M, Hentrich   +3 more
openaire   +2 more sources

Diagnosis and management of neuroendocrine prostate cancer

The Prostate
AbstractBackgroundAlthough most patients with prostate cancer (PC) respond to initial androgen deprivation therapy (ADT), castration‐resistant disease invariably develops. Progression to treatment‐emergent neuroendocrine PC (t‐NEPC) represents a unique mechanism of resistance to androgen receptor (AR)‐targeted therapy in which lineage plasticity and ...
Ivan de Kouchkovsky, Emily Chan, Charles Schloss, Christian Poehlein, Rahul Aggarwal   +4 more
openaire   +2 more sources

Neuroendocrine Differentiation in the Precursors of Prostate Cancer

European Urology, 1996
To review neuroendocrine differentiation in the precursors of prostatic carcinoma (prostatic intraepithelial neoplasia).Background information is given on the prostatic neuroendocrine cell and neuroendocrine differentiation in prostatic carcinoma.
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Molecular model for neuroendocrine prostate cancer progression

BJU International, 2018
Prostate cancer ( PC a) is the most common form of cancer in men in the developed world and the second leading cause of cancer‐related deaths. While advanced PC a is initially controlled with hormonal therapies targeting the androgen receptor (
Ruiqi, Chen, Xuesen, Dong, Martin, Gleave   +2 more
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MYCN Transforms Prostate Epithelium to Neuroendocrine Prostate Cancer

Cancer Discovery, 2016
Abstract Overexpression of MYCN in normal basal prostate cells drives formation of metastatic NEPC.
openaire   +2 more sources

Somatostatin Imaging of Neuroendocrine-Differentiated Prostate Cancer

Clinical Nuclear Medicine, 2015
After prolonged androgen deprivation therapy, a subset of castrate-resistant prostate cancer patients will develop neuroendocrine prostate cancer (NEPC) associated with resistance to further hormonal therapy and frequent visceral metastases. Imaging the presence of somatostatin receptors on the cancer cell surface may provide a readily available ...
Thomas A, Hope, Rahul, Aggarwal, Jeff P, Simko, Henry F, VanBrocklin, Charles J, Ryan   +4 more
openaire   +2 more sources