Results 51 to 60 of about 35,812 (218)

Specific classification and new therapeutic targets for neuroendocrine prostate cancer: A patient-based, diagnostic study

Frontiers in Genetics, 2022
Objective: Neuroendocrine prostate cancer (NEPC) is an aggressive variant of prostate cancer (PC) that may arise de novo or in patients previously treated with hormonal therapies for prostate adenocarcinoma as a mechanism of resistance.
YouZhi Wang, Ning Wu, KeKe Wang, YiHao Liao, JiaNing Guo, BoQiang Zhong, Tao Guo, JiaMing Liang, Ning Jiang   +8 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Lethal disseminated intravascular coagulation induced by primary and metastatic neuroendocrine prostate cancer

IJU Case Reports
Introduction Neuroendocrine prostate cancer has a poor prognosis. Although disseminated intravascular coagulation associated with malignancy can be lethal, it very rarely occurs among patients with primary neuroendocrine prostate cancer.
Takashi Ando, Taro Sasaki, Makoto Naito
doaj   +1 more source

The effect of cytokines on neuroendocrine differentiation in prostate cancer [PDF]

Journal of Men's Health
Prostate cancer is an androgen dependent cancer that can initially be effectively treated with androgen deprivation therapy (ADT). However, during the treatment process, most prostate cancer patients eventually develop drug resistance and gradually ...
Xuezhen Yang, Zemin Liu, Jing Liu, Pengqiang Yang, Zhongzhong Sun, Baicheng Liu, Jianzhong Guo   +6 more
doaj   +1 more source

Dual‐Target Nectin‐4/FAP Heterobivalent Probe 68Ga/177Lu‐FZ‐NF‐1 for Triple‐Negative Breast Cancer: Preclinical Theranostic Evaluation and First‐in‐Human Translation

Advanced Science, EarlyView.
A novel hetero‐bivalent agent, 68Ga/177Lu‐FZ‐NF‐1, concurrently targets Nectin‐4 and FAP in triple‐negative breast cancer. It yields significant preclinical tumor regression and clinically identifies additional metastatic lesions missed by 18F‐FDG PET, demonstrating promising theranostic potential for personalized management.
Ye Li, Li Sun, Xiaoyu Pan, Shuyi Lin, Dongliang Wang, Jianping Zhang, Fengshuang Qiu, Bin Zhu, Lingzhou Zhao, Fengsheng Zhang, Liyan Bai, Bingxin Gu, Xiaoping Xu, Shaoli Song   +13 more
wiley   +1 more source

Urethral metastasis with neuroendocrine differentiation in a patient with prostate cancer treated with hormone deprivation

Indian Journal of Urology, 2019
Adenocarcinoma prostate treated with hormone deprivation may evolve into a neuroendocrine differentiated tumor. Usually visceral metastasis are seen in neuroendocrine tumors.
Karamveer Sabharwal, Anant Kumar, Andleeb Abrari   +2 more
doaj   +1 more source

Implication of β2-adrenergic receptor and miR-196a correlation in neurite outgrowth of LNCaP prostate cancer cells.

PLoS ONE, 2021
The β2-adrenergic receptor has been shown to be involved in neuroendocrine differentiation and to contribute to the development of aggressive prostate cancer.
Ilaria Guerriero, Håkon Ramberg, Krizia Sagini, Manuel Ramirez-Garrastacho, Kristin A Taskén, Alicia Llorente   +5 more
doaj   +1 more source

Progression of prostate cancer to neuroendocrine cell tumor [PDF]

International Journal of Urology, 2001
Abstract Background: The progression to endocrine therapy‐resistant prostate cancer is partly due to clonal change to neuroendocrine cell tumor. To elucidate this pathologic process, the clinical courses of four cases of neuroendocrine cell tumor that were found at autopsy are reported.Methods: Between 1995 and 1999, autopsies were performed for 20 ...
M, Tanaka, Y, Suzuki, K, Takaoka, N, Suzuki, S, Murakami, O, Matsuzaki, J, Shimazaki   +6 more
openaire   +2 more sources