Results 161 to 170 of about 48,932 (217)

The Neuronal Cytoskeleton and Neurofibrillary Tangles [PDF]

, 1986
Dementia of the Alzheimer type, or Alzheimer’s disease, has a characteristic brain histopathology comprising neurofibrillary tangles, senile neuritic plaques, granulovacuolar bodies and Hirano bodies. A correlation between the number of tangles, the extent of the cholinergic deficit and the degree of dementia has been found (Wilcock et al., 1982 ...
Anderton, Brian, Brion, Jean Pierre, Flament Durand, Jacqueline, Haugh, M, Kahn, J., Miller, C.C.J., Probst, A, Ulrich, J   +7 more
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Striatonigral degeneration with neurofibrillary tangles

Acta Neuropathologica, 1993
An autopsy was performed on a 48-year-old woman with clinical features of parkinsonism-plus syndrome with dominating akinesia. Neuropathological examination revealed striato-nigral degeneration (SND) and neurofibrillary tangles (NFT) characterizing progressive supranuclear palsy.
K, Renkawek, M W, Horstink
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Hypothalamic hamartoma with neurofibrillary tangles

Neuropathology, 2016
Hypothalamic hamartomas are rare tumors that typically present in childhood, often with gelastic seizures, precocious puberty, or as a manifestation of Pallister‑Hall syndrome. Neurofibrillary tangles are cytoplasmic aggregates of hyperphosphorylated tau that are best recognized in Alzheimer disease, other tau‐associated neurodegenerative diseases, or ...
Seiji, Yamada, Christopher P, Wood, Jawad A, Shah, Jonathan, Vida, Joseph E, Parisi, Mark E, Jentoft   +5 more
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Morphology of neurofibrillary tangles and senile plaques [PDF]

, 1990
Abnormal filaments (PHF) accumulate in neurons in Alzheimer’s disease in target areas. They fill the pericaryon but are also found in dendrites and axons. Their presence is associated with a disappearance of microtubules and neurofilaments, and an accumulation of dense bodies, altered mitochondria and smooth endoplasmic reticulum.
Flament Durand, Jacqueline, Brion, Jean Pierre   +1 more
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Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification

Acta Neuropathologica, 2003
In the present study the occurrence and distribution of glial fibrillary tangles (GFT) and their related structures in diffuse neurofibrillary tangles with calcification (DNTC) were investigated using Gallyas-Braak (GB) stain. Six cases neuropathologically diagnosed as DNTC were studied (two males and four females).
Naoki, Hashimoto, Tohru, Takeuchi, Ryoko, Ishihara, Katsuyuki, Ukai, Hiroshi, Kobayashi, Hiromu, Iwata, Kiyoshi, Iwai, Yutaka, Mizuno, Haruyasu, Yamaguchi, Hiroto, Shibayama   +9 more
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Immunohistochemical investigation of neurofibrillary tangles and their tau isoforms in brains of limbic neurofibrillary tangle dementia

Neuroscience Letters, 2006
Limbic neurofibrillary tangle dementia (LNTD) is a subset of senile dementia characterized by numerous neurofibrillary tangles (NFT) in the hippocampal area, although there is an absence or scarcity of amyloid deposits (AM) throughout the brain. In the present study, we immunohistochemically investigated regional numbers and tau isoforms of NFT in the ...
Eizo, Iseki, Ryoko, Yamamoto, Norio, Murayama, Michiko, Minegishi, Takashi, Togo, Omi, Katsuse, Kenji, Kosaka, Haruhiko, Akiyama, Kuniaki, Tsuchiya, Rohan, de Silva, Lees, Andrew, Heii, Arai   +11 more
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Mechanisms of neurofibrillary degeneration and the formation of neurofibrillary tangles

1998
Alzheimer disease (AD) has polyetiology. Independent of the etiology the disease is characterized histopathologically by the intraneuronal accumulation of paired helical filaments (PHF), forming neurofibrillary tangles, neuropil threads and dystrophic neurites surrounding the extracellular deposits of beta-amyloid in plaques, the second major lesion ...
K, Iqbal, A C, Alonso, C X, Gong, S, Khatoon, J J, Pei, J Z, Wang, I, Grundke-Iqbal   +6 more
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Ultrastructure of neurofibrillary tangles in Alzheimer’s disease

Virchows Archiv B Cell Pathology Including Molecular Pathology, 1989
The ultrastructure of neurofibrillary tangles (NFT) was examined by electron microscopy. The fibrils of NFT seemed to consists of about eight protofilaments consisting of globular subunits; these protofilaments were helically wound in a longitudinal direction.
T, Miyakawa, S, Katsuragi, K, Araki, T, Hashimura, T, Kimura, R, Kuramoto   +5 more
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Neurofibrillary tangles induced by a sclerosing angioma

Human Pathology, 1979
A sclerosing angioma in the frontal cortex of a 40 year old woman produced local pressure, with resulting alteration of the blood-brain barrier. In the narrow cortical zone affected by chronic pressure, the level of aluminum was significantly elevated; and all neurons had neurofibrillary tangles of the Alzheimer type.
L, Liss, K, Ebner, D, Couri
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Neurofibrillary tangles in the cerebral cortex of sheep

Neuroscience Letters, 1994
Neurofibrillary degeneration, including neurofibrillary tangles (NFTs) and neuritic plaques, is an important pathological hallmark of Alzheimer's disease (AD). Unfortunately, no practical animal model of neurofibrillary degeneration has been described. We report here the presence of structures in the cerebral cortex of sheep, Ovis aries, that resemble ...
P T, Nelson, S G, Greenberg, C B, Saper
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