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Occurrence of neurofibrillary tangles in the celiac ganglia
Acta Neuropathologica, 1989Recently, we incidentally found (NFTs) neurofibrillary tangles in the celiac ganglia of a 61-year-old non-demented woman with familial spastic paraplegia and ...
K, Wakabayashi +3 more
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The Nature of Neurofibrillary Tangles
1985Dementia of the Alzheimer type (ATD), both presenile and senile, has a characteristic brain histopathology comprising neurofibrillary tangles (NFT), senile plaques, granulovacuolar bodies and Hirano bodies. Alzheimer-type NFT are also found in several other diseases, including Down’s syndrome, postencephalitic Parkinson’s disease, dementia pugilistica,
B. H. Anderton +5 more
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Are alzheimer neurofibrillary tangles insoluble polymers?
Life Sciences, 1986The two methods currently available for the bulk isolation of Alzheimer tangles of paired helical filaments (PHF) are based on a brief treatment of a neuronal-enriched preparation with sodium dodecyl sulfate (SDS) (Method I) and on heating of whole brain homogenate with SDS and beta-mercaptoethanol (Method II). PHF were isolated from the same Alzheimer
K, Iqbal +4 more
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Altered aspartate in Alzheimer neurofibrillary tangles
Neurochemical Research, 1992Normal protein-bound L-aspartyl/L-asparaginyl residues may undergo post-translational modification by racemization to D-aspartate, or by isomerization to the L-isoaspartyl form in which the peptide chain links through the beta carboxyl group of the residue.
I L, Payan +5 more
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Neurofibrillary Tangles and Alzheimer’s Disease
European Neurology, 1998The neuropathological diagnosis of Alzheimer’s disease relies on the presence of both neurofibrillary tangles and senile plaques. The number of neurofibrillary tangles is tightly linked to the degree of dementia, suggesting that the formation of neurofibrillary tangles more directly correlates with neuronal dysfunction.
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Neurofibrillary tangles of paired helical filaments
Journal of the Neurological Sciences, 1976The abnormal aggregates of fibrillar material found in neurons in Alzheimer's disease, senile dementia, the Guam Parkinsonism-Dementia complex, Down's syndrome, and postencephalitic Parkinsonism were studied by means of tilt-stage electron microscopy and with X-ray images of scale models of a bifilar helix.
H M, Wiśniewski +2 more
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Reappraisal of neurofibrillary tangles
Acta Neuropathologica, 1989We have studied the immunohistochemical reactivity and ultrastructure of both neurofibrillary tangles (NFTs) occurring with severe neurofibrillary diseases, and Pick bodies (PBs) associated with Pick's disease. The NFTs and PBs did not react immunohistochemically with the anti-nonphosphorylated neurofilament monoclonal antibody irrespective of whether ...
S, Kato, H, Nakamura, E, Otomo
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Diffuse Neurofibrillary Tangles with Calcification
2010Diffuse neurofibrillary tangles with calcification (DNTC) is a primary and sporadic presenile dementia that is characterized by temporal and/or frontal atrophy with diffuse neurofibrillary tangles (NFTs) and Fahr-type calcification without senile plaques (SPs).
Shigetoshi Kuroda +5 more
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