Results 1 to 10 of about 102,686 (380)

Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies

Frontiers in Neuroscience, 2021
Biomarkers of neurodegeneration and neuronal injury have the potential to improve diagnostic accuracy, disease monitoring, prognosis, and measure treatment efficacy.
Aidong Yuan, Aidong Yuan, Ralph A. Nixon, Ralph A. Nixon, Ralph A. Nixon   +4 more
doaj   +2 more sources

Cerebrospinal fluid level of phosphorylated neurofilament heavy chain is higher in converting clinically isolated syndrome and correlates with CAMP response element-binding protein concentration

Neurological Sciences and Neurophysiology, 2021
Introduction: Prevision of conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) is required to avoid unnecessary use of immunomodulating agents and to recognize patients with high disease activity.
Mehmet Gencer, Gizem Koral, Elif Sanli, Selen Cirak, Ece Akbayir, Hande Yuceer, Tugce Kizilay, Ruziye Erol Yildiz, Sibel Penbe Yentur, Vuslat Yilmaz, Erdem Tuzun, Recai Turkoglu   +11 more
doaj   +1 more source

Role of Blood Neurofilaments in the Prognosis of Amyotrophic Lateral Sclerosis: A Meta-Analysis

Frontiers in Neurology, 2021
Background: Neurofilaments in cerebrospinal fluid (CSF) and in blood are considered promising biomarkers of amyotrophic lateral sclerosis (ALS) because their levels can be significantly increased in patients with ALS. However, the roles of neurofilaments,
Yan-ni Zhou, Yan-ni Zhou, You-hong Chen, Si-qi Dong, Wen-bo Yang, Ting Qian, Xiao-ni Liu, Qi Cheng, Jiu-cun Wang, Jiu-cun Wang, Xiang-jun Chen, Xiang-jun Chen   +11 more
doaj   +1 more source

Phosphorylated CRMP1, axon guidance protein, is a component of spheroids and is involved in axonal pathology in amyotrophic lateral sclerosis

Frontiers in Neurology, 2022
In amyotrophic lateral sclerosis (ALS), neurodegeneration is characterized by distal axonopathy that begins at the distal axons, including the neuromuscular junctions, and progresses proximally in a “dying back” manner prior to the degeneration of cell ...
Yuko Kawamoto, Yuko Kawamoto, Mikiko Tada, Tetsuya Asano, Haruko Nakamura, Aoi Jitsuki-Takahashi, Hiroko Makihara, Shun Kubota, Shunta Hashiguchi, Misako Kunii, Toshio Ohshima, Yoshio Goshima, Hideyuki Takeuchi, Hiroshi Doi, Fumio Nakamura, Fumiaki Tanaka   +15 more
doaj   +1 more source

Paradoxical increase of neurofilaments in SMA patients treated with onasemnogene abeparvovec-xioi

Frontiers in Neurology, 2023
Background/ObjectiveNeurofilament light chain (NfL) has been proposed as a biomarker reflecting disease severity and therapy response in children with spinal muscular atrophy type 1 and 2 (SMA1 and 2). The objective of this study was to examine how serum
Marina Flotats-Bastardas, Lisa Bitzan, Charlotte Grell, Kyriakos Martakis, Kyriakos Martakis, Benedikt Winter, Michael Zemlin, Claudia D. Wurster, Zeljko Uzelac, Claudia Weiß, Andreas Hahn   +10 more
doaj   +1 more source

A Method to Combine Neurofilament Light Measurements From Blood Serum and Plasma in Clinical and Population-Based Studies

Frontiers in Neurology, 2022
IntroductionNeurofilament light (NfL) can be detected in blood of healthy individuals and at elevated levels in those with different neurological diseases.
Nicole Rübsamen, Eline A. J. Willemse, David Leppert, Heinz Wiendl, Matthias Nauck, Matthias Nauck, André Karch, Jens Kuhle, Klaus Berger   +8 more
doaj   +1 more source

Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimer's Disease

Chinese Journal of Physiology, 2021
Clinically typical dementia Alzheimer's disease (AD) is associated with abnormal auditory processing. However, possible molecular mechanisms responsible for the auditory pathology of AD patients are not known. According to our past research findings that
Sheue-Er Wang, Chung-Hsin Wu
doaj   +1 more source

Case Report: Successful Stabilization of Marburg Variant Multiple Sclerosis With Ocrelizumab Following High-Dose Cyclophosphamide Rescue

Frontiers in Neurology, 2021
The Marburg variant of multiple sclerosis (Marburg MS) is the most aggressive form of MS, often leading to death soon after onset. Here we describe the case of a 26-year-old Marburg MS patient presenting with severe neurological deficits requiring ...
Valeria Koska, Moritz Förster, Katja Brouzou, Maryam Hatami, Ercan Arat, Ahmet Aytulun, Philipp Albrecht, Orhan Aktas, Patrick Küry, Sven G. Meuth, David Kremer   +10 more
doaj   +1 more source

Breaking the amyotrophic lateral sclerosis early diagnostic barrier: the promise of general markers

Exploration of Neuroprotective Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is associated with selective and progressive loss of motor neurons. As a consequence, the symptoms of ALS are muscle cramps and weakness, and it eventually leads to death. The
Yizhou Lu, Lu He, Huanyu Meng, Sheng Chen, Qinming Zhou   +4 more
doaj   +1 more source

Neurofilament ELISA validation [PDF]

Journal of Immunological Methods, 2010
Neurofilament proteins (Nf) are highly specific biomarkers for neuronal death and axonal degeneration. As these markers become more widely used, an inter-laboratory validation study is required to identify assay criteria for high quality performance.The UmanDiagnostics NF-light (R)enzyme-linked immunoabsorbent assays (ELISA) for the neurofilament light
Petzold, A., Altintas, A., Andreoni, L., Bartos, A., Berthele, A., Blankenstein, M.A., Buee, L., Castellazzi, M., Cepok, S., Comabella, M., Constantinescu, C.S., Deisenhammer, F., Deniz, G., Erten, G., Espino, M., Fainardi, E., Franciotta, D., Freedman, M.S., Giedraitis, V., Gilhus, N.E., Giovannoni, G., Glabinski, A., Grieb, P., Hartung, H.P., Hemmer, B., Herukka, S.K., Hintzen, R., Ingelsson, M., Jackson, S., Jacobsen, S., Jafari, N., Jalosinski, M., Jarius, S., Kapaki, E., Kieseier, B.C., Koel-Simmelink, M.J., Kornhuber, J., Kuhle, J., Kurzepa, J., Lalive, P.H., Lannfelt, L., Lehmensiek, V., Lewczuk, P., Livrea, P., Marnetto, F., Martino, D., Menge, T., Norgren, N., Papuc, E., Paraskevas, G.P., Pirttilä, T., Rajda, C., Rejdak, K., Ricny, J., Ripova, D., Rosengren, L., Ruggieri, M., Schraen, S., Shaw, G., Sindic, C., Siva, A., Stigbrand, T., Stonebridge, I., Topcular, B., Trojano, M., Tumani, H., Twaalfhoven, H.A., Vecsei, L., Van Pesch, V., Vanderstichele, H., Vedeler, C., Verbeek, M.M., Verbeek, M.M., Villar, L.M., Weissert, R., Wildemann, B., Yang, C., Yao, K., Teunissen, C.E.   +78 more
openaire   +10 more sources