Results 11 to 20 of about 102,686 (380)

Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease [PDF]

Nature Medicine, 2019
Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ultrasensitive immunoassay technology ...
Allegri, Ricardo, Alzheimer Network, Amtashar, Fatima, Apel, Anja, Barro, Christian, Bateman, Randall, Bateman, Randall J., Benzinger, Tammie, Benzinger, Tammie L. S., Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chhatwal, Jasmeer, Chhatwal, Jasmeer, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, DiBari, Siri Houeland, Donahue, Tamara, Douglas, Jane, D’Mello, Mirelle, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Fagan, Anne M., Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Ghetti, Bernardino, Ghetti, Bernardino, Goate, Alison, Goate, Alison M., Goldman, Jill, Gordon, Brian, Gordon, Brian A., Graff-Radford, Neill, Graff-Radford, Neill R., Gray, Julia, Gräber, Susanne, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Jucker, Mathias, Kaeser, Stephan A., Karch, Celeste, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Koeppe, Robert, Kuder-Buletta, Elke, Kuder-Buletta, Elke, Kuhle, Jens, LaFougere, Christian, Laske, Christoph, Laske, Christoph, Lee, Jae-Hong, Levin, Johannes, Levin, Johannes, Marcus, Daniel, Martins, Ralph, Martins, Ralph, Mason, Neal Scott, Masters, Colin, Masters, Colin L., Maue-Dreyfus, Denise, McDade, Eric, McDade, Eric M., Montoya, Lucy, Mori, Hiroshi, Morris, John, Morris, John C., Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Noble, James M., Norton, Joanne, Perrin, Richard, Preische, Oliver, Raichle, Marc, Ringman, John, Ringman, John M., Roh, Jee Hoon, Rossor, Martin N., Salloway, Stephen, Salloway, Stephen, Schofield, Peter, Schofield, Peter R., Schultz, Stephanie A., Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Vöglein, Jonathan, Wang, Guoqiao, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong   +122 more
core   +4 more sources

Neurofilaments and Neurofilament Proteins in Health and Disease [PDF]

Cold Spring Harbor Perspectives in Biology, 2017
SUMMARYNeurofilaments (NFs) are unique among tissue-specific classes of intermediate filaments (IFs) in being heteropolymers composed of four subunits (NF-L [neurofilament light]; NF-M [neurofilament middle]; NF-H [neurofilament heavy]; and α-internexin or peripherin), each having different domain structures and functions.
Aidong, Yuan, Mala V, Rao, , Veeranna, Ralph A, Nixon   +3 more
openaire   +3 more sources

Dietary vitamin K intake is associated with decreased neurofilament light chain among middle-aged and older adults from the NHANES [PDF]

Frontiers in Nutrition
PurposeNeurofilament-light chain (NfL) is associated with neurodegenerative diseases, which are increasingly prevalent with aging. Vitamin K has been shown a neuroprotective effect.
Jing Luo, Song Lin
doaj   +2 more sources

A multicentre validation study of the diagnostic value of plasma neurofilament light

Nature Communications, 2021
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome,
N. Ashton, S. Janelidze, A. Al Khleifat, A. Leuzy, E. L. van der Ende, T. Karikari, A. Benedet, T. Pascoal, A. Lleó, L. Parnetti, D. Galimberti, L. Bonanni, A. Pilotto, A. Padovani, J. Lycke, L. Novakova, M. Axelsson, L. Velayudhan, G. Rabinovici, B. Miller, C. Pariante, N. Nikkheslat, S. Resnick, M. Thambisetty, M. Schöll, G. Fernández-Eulate, F. Gil-Bea, A. López de Munain, A. Al-Chalabi, P. Rosa-Neto, A. Strydom, P. Svenningsson, E. Stomrud, A. Santillo, D. Aarsland, J. V. van Swieten, S. Palmqvist, H. Zetterberg, K. Blennow, Abdul Hye, O. Hansson   +40 more
semanticscholar   +1 more source

Neurofilament light‐chain response during therapy with antisense oligonucleotide tofersen in SOD1‐related ALS: Treatment experience in clinical practice

Muscle and Nerve, 2023
In amyotrophic lateral sclerosis (ALS) caused by superoxide dismutase 1 (SOD1) gene mutations (SOD1‐ALS), the antisense oligonucleotide tofersen had been investigated in a phase III study (VALOR) and subsequently introduced in an expanded access program.
Thomas Meyer, Peggy Schumann, P. Weydt, S. Petri, Y. Koc, S. Spittel, S. Bernsen, R. Günther, Jochen H Weishaupt, Marie Dreger, Felix Kolzarek, D. Kettemann, J. Norden, M. Boentert, Maximilian Vidovic, C. Meisel, C. Münch, A. Maier, Péter Körtvélyessy   +18 more
semanticscholar   +1 more source

Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5–90 years

Brain Communications, 2022
The recent development of assays that accurately quantify neurofilament light, a neuronal cytoskeleton protein, in plasma has generated a vast literature supporting that it is a sensitive, dynamic, and robust biomarker of neuroaxonal damage. As a result,
Joel Simrén, U. Andreasson, J. Gobom, Marc Suarez Calvet, B. Borroni, C. Gillberg, L. Nyberg, R. Ghidoni, E. Fernell, Mats Johnson, H. Depypere, C. Hansson, I. Jonsdottir, H. Zetterberg, K. Blennow   +14 more
semanticscholar   +1 more source

Uman-type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration

Brain Communications, 2023
Recent work shows that certain antibody-based assays for the neurofilament light chain detect informative signals in the CSF and blood of human and animals affected by a variety of CNS injury and disease states. Much of this work has been performed using
Gerry Shaw, Irina Madorsky, Ying Li, Yongsheng Wang, M. Jorgensen, Sabhya Rana, D. Fuller   +6 more
semanticscholar   +1 more source

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Nature Communications, 2020
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for repeated assessments.
M. Khalil, L. Pirpamer, E. Hofer, Margarete M. Voortman, Christian Barro, D. Leppert, P. Benkert, S. Ropele, C. Enzinger, F. Fazekas, R. Schmidt, J. Kuhle   +11 more
semanticscholar   +1 more source

Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease

JAMA Neurology, 2021
Key Points Question What is the potential of blood-based biomarkers for predicting and monitoring the progression of Alzheimer disease neurodegeneration?
A. Moscoso, M. Grothe, N. Ashton, T. Karikari, Juan Lantero Rodríguez, A. Snellman, M. Suárez‐Calvet, K. Blennow, H. Zetterberg, M. Schöll   +9 more
semanticscholar   +1 more source

Motor phenotypes and neurofilament light chain in genetic amyotrophic lateral sclerosis-results from a multicenter screening program. [PDF]

J Neurol
Schmitt P, Schumann P, Koerbs A, Lin HJ, Grehl T, Weyen U, Petri S, Rödiger A, Steinbach R, Großkreutz J, Bernsen S, Weydt P, Wolf J, Günther R, Baum P, Metelmann M, Weishaupt JH, Streubel B, Kasper DC, Koc Y, Kettemann D, Norden J, Walter B, Münch C, Spittel S, Maier A, Körtvélyessy P, Meyer T.   +27 more
europepmc   +3 more sources