Results 21 to 30 of about 102,686 (380)

The potential of serum neurofilament as biomarker for multiple sclerosis

Brain : a journal of neurology, 2021
Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal damage as well as its quantification is a critical step for patients.
S. Bittner, Jiwon Oh, E. Havrdová, M. Tintoré, F. Zipp   +4 more
semanticscholar   +1 more source

Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface

Annals of Clinical and Translational Neurology, 2022
Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values.
L. Vermunt, Marco Otte, I. Verberk, J. Killestein, A. Lemstra, W. M. van der Flier, Y. Pijnenburg, E. Vijverberg, F. Bouwman, Gido Gravesteijn, W. V. D. van de Berg, P. Scheltens, Argonde C Van Harten, E. Willemse, C. Teunissen   +14 more
semanticscholar   +1 more source

The multifaceted role of neurofilament light chain protein in non-primary neurological diseases

Brain : a journal of neurology, 2022
The advancing validation and exploitation of cerebrospinal fluid and blood neurofilament light chain protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic and prognostic approach to neurological diseases.
Samir Abu-Rumeileh, A. Abdelhak, M. Foschi, L. D’Anna, M. Russo, P. Steinacker, J. Kuhle, H. Tumani, K. Blennow, M. Otto   +9 more
semanticscholar   +1 more source

Clinical Phenotyping and Biomarkers in Spinal and Bulbar Muscular Atrophy

Frontiers in Neurology, 2021
Background: Spinal and bulbar muscular atrophy (SBMA) or Kennedy disease [OMIM: 313200] is a rare X-linked neuromuscular disease. Patients commonly present with muscle cramps, tremors, leg weakness, dysarthria and dysphagia.Methods: We deeply phenotyped ...
Elina Millere, Elina Millere, Elina Millere, Dmitrijs Rots, Ieva Glazere, Ieva Glazere, Gita Taurina, Natalja Kurjane, Natalja Kurjane, Viktorija Priedite, Linda Gailite, Kaj Blennow, Kaj Blennow, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Henrik Zetterberg, Viktorija Kenina, Viktorija Kenina   +18 more
doaj   +1 more source

Serum Neurofilament Levels in Children With Febrile Seizures and in Controls

Frontiers in Neuroscience, 2020
ObjectiveNeuroaxonal damage is reflected by serum neurofilament light chain (sNfL) values in a variety of acute and degenerative diseases of the brain. The aim of this study was to investigate the impact of febrile and epileptic seizures on sNfL, serum ...
Katrina S. Evers, Melanie Hügli, Sotirios Fouzas, Severin Kasser, Christian Pohl, Christian Pohl, Benjamin Stoecklin, Luca Bernasconi, Jens Kuhle, Sven Wellmann, Sven Wellmann   +10 more
doaj   +1 more source

Generation of a Spiral Ganglion Neuron Degeneration Mouse Model

Frontiers in Cell and Developmental Biology, 2021
Spiral ganglion neurons (SGNs) can be injured by a wide variety of insults. However, there still is a lack of degeneration models to specifically damage the SGNs without disturbing other types of cells in the inner ear. This study aims to generate an SGN-
Zhengqing Hu, Zhengqing Hu, Fnu Komal, Aditi Singh, Meng Deng   +4 more
doaj   +1 more source

Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]

, 2006
Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia, Abou-Donia, Alan J. Hargreaves, Barber, Barber, Brunet, Casida, Chambers, Denizot, Ehrich, El-Fawal, Eto, Flaskos, Flaskos, Forshaw, Fowler, Glynn, Glynn, Gupta, Hatch, Henschler, Ian C. Coutts, James, Jensen, John Flaskos, Johnson, Johnson, Johnson, Jortner, Jortner, Keilbaugh, Laemmli, Lee, Li, Lowry, Magdalini Sachana, Mary Bountouri, Maxine J. Fowler, Nixon, Nomeir, Nomeir, Nostrandt, Nostrandt, Paul Glynn, Perron, Rosenstock, Schmuck, Sharma, Song, Suwita, Towbin, Van Teinhoven, Veeranna, Veronesi, W. Graham McLean, Wayne Harris, Zhao   +56 more
core   +1 more source

Exploring Neurofilament Light Chain and Exosomes in the Genetic Forms of Frontotemporal Dementia

Frontiers in Neuroscience, 2022
Differential diagnosis of neurological disorders and their subtype classification are challenging without specific biomarkers. Genetic forms of these disorders, typified by an autosomal dominant family history, could offer a window to identify potential ...
Roberta Zanardini, Claudia Saraceno, Luisa Benussi, Rosanna Squitti, Roberta Ghidoni   +4 more
doaj   +1 more source

Neurofilament light chain as a biomarker in neurological disorders

Journal of Neurology Neurosurgery & Psychiatry, 2019
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment.
L. Gaetani, K. Blennow, P. Calabresi, M. Di Filippo, L. Parnetti, H. Zetterberg   +5 more
semanticscholar   +1 more source

Neurofilament Light Chain as a Biomarker for Cognitive Decline in Parkinson Disease

Movement Disorders, 2021
Neurofilament light chain protein (NfL) is a promising biomarker of neurodegeneration.
Whitley W. Aamodt, T. Waligórska, Junchao Shen, T. Tropea, A. Siderowf, D. Weintraub, M. Grossman, D. Irwin, D. Wolk, S. Xie, J. Trojanowski, L. Shaw, A. Chen-Plotkin   +12 more
semanticscholar   +1 more source