A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel
Advanced Science, EarlyView.An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu +12 more
wiley +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Effect of Adult Neurogenesis on Sparsely Synchronized Rhythms of The Granule Cells in The Hippocampal Dentate Gyrus [PDF]
arXiv, 2023 We are concerned about the main encoding granule cells (GCs) in the hippocampal dentate gyrus (DG). Young immature GCs (imGCs) appear through adult neurogenesis. In comparison to the mature GCs (mGCs) (born during development), the imGCs show high activation due to lower firing threshold.
arxiv
RACK7 Interacts with PRC2 Complex to Regulate Astrocyte Development
Advanced Science, EarlyView.The study investigates the role of RACK7 in brain development using a conditional knockout mouse model. RACK7 deficiency results in developmental defects and abnormal astrocyte development by disrupting H3K27me3 chromatin binding. The underlying mechanism involves RACK7 interacting with the PRC2 complex to regulate the genomic localization of SUZ12 and
Fangfang Jiao +9 more
wiley +1 more source
Neurogenesis and multiple plasticity mechanisms enhance associative memory retrieval in a spiking network model of the hippocampus [PDF]
arXiv, 2017 Hippocampal CA3 is crucial for the formation of long-term associative memory. It has a heavily recurrent connectivity, and memories are thought to be stored as memory engrams in the CA3. However, despite its importance for memory storage and retrieval, spiking network models of the CA3 to date are relatively small-scale, and exist as only proof-of ...
arxiv
Neurogenesis Dynamics-inspired Spiking Neural Network Training Acceleration [PDF]
arXiv, 2023 Biologically inspired Spiking Neural Networks (SNNs) have attracted significant attention for their ability to provide extremely energy-efficient machine intelligence through event-driven operation and sparse activities. As artificial intelligence (AI) becomes ever more democratized, there is an increasing need to execute SNN models on edge devices ...
arxiv
Advanced Science, EarlyView.The genome of Megachile rotundata, an extensively managed solitary pollination bee species, has been sequenced, covering 280.68 Mb and predicting 10 701 genes. The study reveals significant expansions of the Toll gene family and their abundant expression in diapause prepupae, highlighting enhanced immune responses during diapause. This genome serves as
Rangjun Shi +8 more
wiley +1 more source
Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration
EMBO Molecular Medicine, 2016 Pantothenate kinase‐associated neurodegeneration (PKAN) is an early onset and severely disabling neurodegenerative disease for which no therapy is available.
Daniel I Orellana +15 more
doaj +1 more source
Neurotrophic Effects of Intermittent Fasting, Calorie Restriction and Exercise: A Review and Annotated Bibliography [PDF]
arXiv, 2023 In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), caloric restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult neurogenesis (NSPAN) are essential examples of these neurotrophic effects. The importance in this respect of the metabolic
arxiv
Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells [PDF]
, 2002 In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively.
Anderson, David J. +3 more
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