Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons
iScienceSummary: Post-translational modifications (PTMs) of microtubules (MTs) endow them with specific properties that are essential for key cellular functions, such as axonal transport.
Romain Le Bail +7 more
doaj +1 more source
Determining the Sufficiency of the bHLH Gene Nato3 in Dopamine Neurogenesis [PDF]
, 2012 Floor plate cells of the mesencephalon have the ability to become more floor plate cells or differentiate into dopamine containing neurons. Maturation of these neurons can be marked by the stage of differentiation. When dopamine neurons of the substantia
Kaufman, Darcy Nichole
core
The maternal brain: an organ with peripartal plasticity. [PDF]
, 2014 The time of pregnancy, birth, and lactation, is characterized by numerous specific alterations in several systems of the maternal body. Peripartum-associated changes in physiology and behavior, as well as their underlying molecular mechanisms, have been ...
Aigner, Ludwig +7 more
core +1 more source
Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair
Advanced Science, EarlyView.We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing +10 more
wiley +1 more source
How hunger guides new brain cells to their destination
eLifeBlood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.
Fang-Shin Nian, Laurent Nguyen
doaj +1 more source
Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E is an element of 4 status and cerebrospinal fluid amyloid-beta 42 levels [PDF]
, 2014 Introduction: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer's disease (AD).
Annas, Peter +14 more
core +1 more source
Targeting Adult Neurogenesis for Brain Recovery After Stroke: The Next Frontier in Stroke Medicine
, 2022 One in four people over age 25 will have a stroke in their lifetime. Globally, an estimated 80 million people are currently living with stroke with many experiencing chronic disability and unmet needs.
Ong, Lin Kooi +4 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Stimulating Neuroprotective and Regenerative Mechanisms in Alzheimer Disease [PDF]
, 2013 The processes involved in neuroprotection and brain repair are an important aspect of the preservation and restoration of neuronal functions affected by pathological lesions.
Lilja, Anna M
core +1 more source
Advanced Science, EarlyView.ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen +7 more
wiley +1 more source