Results 91 to 100 of about 177,971 (301)

Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus [PDF]

, 2017
Adolescence is a sensitive period of neurodevelopment during which life experiences and the surrounding environment can have profound effects on the brain.
Danka A. Kozareva, Yvonne M. Nolan, Nolan, Yvonne M., O\u27Leary, Olivia F., John F. Cryan, Kozareva, Danka A., Olivia F. O'Leary, Cryan, John F., O'Leary, Olivia F.   +8 more
core   +1 more source

Neural Circuitry–Neurogenesis Coupling Model of Depression

, 2021
Depression is characterized by the disruption of both neural circuitry and neurogenesis. Defects in hippocampal activity and volume, indicative of reduced neurogenesis, are associated with depression-related behaviors in both humans and animals ...
Il Bin Kim, Seon-Cheol Park
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis [PDF]

, 2017
In the adult mammalian brain, new neurons continue to be produced throughout life in two main regions in the brain, the subgranular zone (SGZ) in the hippocampus and the subventricular zone in the walls of the lateral ventricles. Neural stem cells (NSCs)
Lourenco, Ana S., Fernandes, Raquel, Vanessa M. Machado, Ana Sofia Lourenço, Cláudia Florindo, Araújo, Inês M., Raquel Fernandes, Florindo, Claudia, Caetana M. Carvalho, Machado, Vanessa M., Lourenço, Ana Sofia, Inês M. Araújo, Araújo, Inês, Machado, Vanessa, Carvalho, Caetana M.   +14 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

QUANTITATIVE ASSESSMENT OF THE ANGULAR BUNDLE IN ALZHEIMER'S DISEASE

IBRO Neuroscience Reports, 2023
Sandra Cebada Sánchez, José Carlos Delgado González, José Florensa-Vila, Carlos De La Rosa-Prieto, Juan Raspeño Garcia, Rubén Rico-Sánchez, Ricardo Insausti, Emilio Artacho-Pérula   +7 more
doaj   +1 more source

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

The Effect of Bacterial Lipopolysaccharides on Immune Function and Adult Neurogenesis in the cricket, Acheta domesticus

, 2012
Neurogenesis is the phenomenon in which the brain produces new neurons. Neurons, which are located in the brain and spinal cord, are especially important to an organism’s function, as they allow for communication and information processing.
Mendoza, Megan Ann
core  

Beyond water channel: Aquaporin-4 in adult neurogenesis

, 2010
Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the
Chen, XM, Li, Y, Shen, J, Gu, Y, Zhou, Y, Zheng, GQ, Zhao, SZ, Xing-miao Chen, Shu-zhi Zhao, Yun Zhou, Yue Li, Yong Gu, Guo-qing Zheng, Jiangang Shen   +13 more
core   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source