Results 111 to 120 of about 177,971 (301)

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Enhanced Dentate Neurogenesis after Brain Injury Undermines Long-Term Neurogenic Potential and Promotes Seizure Susceptibility

Stem Cell Reports, 2017
Hippocampal dentate gyrus is a focus of enhanced neurogenesis and excitability after traumatic brain injury. Increased neurogenesis has been proposed to aid repair of the injured network.
Eric J. Neuberger, Bogumila Swietek, Lucas Corrubia, Anagha Prasanna, Vijayalakshmi Santhakumar   +4 more
doaj   +1 more source

Neurogenesis and neuronal regeneration in status epilepticus [PDF]

, 2013
Neurogenesis in the adult central nervous system has been well documented in several mammals including humans. By now, a plethora of data has been generated with the aim of understanding the molecular and cellular events governing neurogenesis.
Aigner, Ludwig, Marschallinger, Julia, Rotheneichner, Peter, Couillard-Despres, Sebastien   +3 more
core   +1 more source

Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism

Advanced Science, EarlyView.
Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He, Yuwen Wang, Jonathan F. Gong, Yiting Lei, Fei Jin, Weihong Zhu, Rocky S. Tuan, Zhong Alan Li   +7 more
wiley   +1 more source

Neurogenesis-mediated Forgetting in Morris Water Maze [PDF]

, 2020
Neurogenesis, the generation of new neurons in the hippocampus, has been identified as an underlying mechanism for forgetting of hippocampus-dependent memories in adult and infant mice.
Duan, Chunan
core   +1 more source

MeCP2 gene dosage-dependent neurodevelopmentally restricted defects arise by aberrant activation of cell fate-determining bivalent genes

Nature Communications
The overexpression of MECP2 leads to severe neurological deficits in MECP2 duplication syndrome, and its dosage is considered a risk factor in gene therapy for Rett syndrome.
Mirko Luoni, Michal Kubacki, Serena Gea Giannelli, Francesca Morosi, Claudia Di Berardino, Angelo Iannielli, Alessandro Sessa, Gaia Colasante, Emanuele Di Patrizio Soldateschi, Chiara Lanzuolo, Vania Broccoli   +10 more
doaj   +1 more source

Beyond amyloid and tau: rethinking Alzheimer’s disease through less explored avenues

Open Biology
Neurodegenerative diseases, particularly Alzheimer’s disease (AD), pose a significant challenge in ageing populations. Our current understanding indicates that the onset of toxic amyloid and tau protein pathologies initiates disease progression. However,
M. Gyimesi, R. K. Okolicsanyi, L. M. Haupt   +2 more
doaj   +1 more source

Adult Neurogenesis in Parkinson’s Disease

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. Its pathogenesis is based on diminution of neurons in the substantia nigra (SN) that under normal conditions acts as the source of dopamine in the nigrostriatal circuit ...
Mochizuki, Hideki
core   +1 more source

Neurogenesis in adult human

, 1996
THIS report describes neurogenesis in the adult human olfactory epithelium in vitro. Olfactory epithelium was collected at autopsy and by biopsy, and grown in serum-free medium.
Livesey, Jonathon, MacDonald, Kelli P. A., Murrell, Wayne, MacDonald, Kelli P.A., Bates, Paul R., McGrath, John, Ray-Barruel, Gillia, Mackay Sim, Alan, Mackay-Sim, Alan, Bushell, Gillian R.   +9 more
core   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source