Results 111 to 120 of about 253,178 (331)

Enhanced Dentate Neurogenesis after Brain Injury Undermines Long-Term Neurogenic Potential and Promotes Seizure Susceptibility

Stem Cell Reports, 2017
Hippocampal dentate gyrus is a focus of enhanced neurogenesis and excitability after traumatic brain injury. Increased neurogenesis has been proposed to aid repair of the injured network.
Eric J. Neuberger, Bogumila Swietek, Lucas Corrubia, Anagha Prasanna, Vijayalakshmi Santhakumar   +4 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids

Advanced Science, EarlyView.
Folic acid (FA) and multivitamins/minerals (MVM) are recommended for the prevention of neural tube defects (NTDs). Using a novel human neural tube‐like organoid system and mouse models, the study compares the effectiveness of two supplements on NTDs and cellular behaviors.
Huili Li, Jing Zhang, Lori Bulwith, Lee Niswander   +3 more
wiley   +1 more source

Beyond amyloid and tau: rethinking Alzheimer’s disease through less explored avenues

Open Biology
Neurodegenerative diseases, particularly Alzheimer’s disease (AD), pose a significant challenge in ageing populations. Our current understanding indicates that the onset of toxic amyloid and tau protein pathologies initiates disease progression. However,
M. Gyimesi, R. K. Okolicsanyi, L. M. Haupt   +2 more
doaj   +1 more source

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis and expression of longevity gene Klotho (Microarray dataset)

, 2021
Sandrine Thuret
openalex   +1 more source

Nap1L4a Cooperates with Scl/Klf1 to Recruit H2A.Z in Mediating Interactions Among Cis‐Regulatory Elements and Transcription Required for Primitive Erythropoiesis in Zebrafish

Advanced Science, EarlyView.
Nap1l4a is required in erythropoiesis and hypoxia responses via physical interaction with Klf1 and Scl to recruit the histone variant H2A.Z. This facilitates its associated cis‐regulatory element (CRE) remodeling and the consequent chromatin assembly, and activates the transcription of erythroid lineage‐specific genes.
JiaHao Shi, FuMing Lai, Zheng Shen, XiaoYan Zhang, HanFei Wang, WenYe Liu, YunLong Wang, KuanYu Li, GuoLiang Li, YaPing Fang, Jing‐Xia Liu   +10 more
wiley   +1 more source

Caffeic acid protects against l-methionine induced reduction in neurogenesis and cognitive impairment in a rat model

Heliyon
l-methionine (L-met) is a substantial non-polar amino acid for normal development. L-met is converted to homocysteine that leads to hyperhomocysteinemia and subsequent excessive homocysteine in serum resulting in stimulating oxidative stress and vascular
Apiwat Sirichoat, Oabnithi Dornlakorn, Rasa Saenno, Anusara Aranarochana, Nataya Sritawan, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat   +7 more
doaj   +1 more source

Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli

Neural Plasticity, 2018
Several interventions have been shown to counteract the effects of stress that may be related to improved neuroplasticity and neuronal activation. In this sense, environmental enrichment (ENR) protects against acute stress and increases neuroplasticity ...
Enrique Flores-Gutiérrez, Edith Araceli Cabrera-Muñoz, Nelly Maritza Vega-Rivera, Leonardo Ortiz-López, Gerardo Bernabé Ramírez-Rodríguez   +4 more
doaj   +1 more source

Single-Cell RNA Sequencing of hESC-Derived 3D Retinal Organoids Reveals Novel Genes Regulating RPC Commitment in Early Human Retinogenesis. [PDF]

, 2019
The development of the mammalian retina is a complicated process involving the generation of distinct types of neurons from retinal progenitor cells (RPCs) in a spatiotemporal-specific manner.
An, Qin, Fan, Guoping, Hu, Youjin, Liu, Qinghuai, Mao, Xiying, Wang, Jinmei, Xi, Huiyu, Yang, Xian-Jie, Yuan, Songtao, Zhang, Xiangmei   +9 more
core  

An Adaptive Threshold in Mammalian Neocortical Evolution

, 2013
Expansion of the neocortex is a hallmark of human evolution. However, it remains an open question what adaptive mechanisms facilitated its expansion.
Huttner, Wieland B, Kalinka, Alex T., Kelava, Iva, Lewitus, Eric, Tomancak, Pavel   +4 more
core   +3 more sources