Results 41 to 50 of about 142,373 (148)

Regulation of Injury-Induced Neurogenesis by Nitric Oxide

Stem Cells International, 2012
The finding that neural stem cells (NSCs) are able to divide, migrate, and differentiate into several cellular types in the adult brain raised a new hope for restorative neurology.
Bruno P. Carreira, Caetana M. Carvalho, Inês M. Araújo   +2 more
doaj   +1 more source

Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons

iScience
Summary: Post-translational modifications (PTMs) of microtubules (MTs) endow them with specific properties that are essential for key cellular functions, such as axonal transport.
Romain Le Bail, Bernard Lakaye, Ira Espuny-Camacho, Carsten Janke, Maria M. Magiera, Dominique Engel, Carla G. Silva, Laurent Nguyen   +7 more
doaj   +1 more source

Coenzyme A corrects pathological defects in human neurons of PANK2‐associated neurodegeneration

EMBO Molecular Medicine, 2016
Pantothenate kinase‐associated neurodegeneration (PKAN) is an early onset and severely disabling neurodegenerative disease for which no therapy is available.
Daniel I Orellana, Paolo Santambrogio, Alicia Rubio, Latefa Yekhlef, Cinzia Cancellieri, Sabrina Dusi, Serena G Giannelli, Paola Venco, Pietro G Mazzara, Anna Cozzi, Maurizio Ferrari, Barbara Garavaglia, Stefano Taverna, Valeria Tiranti, Vania Broccoli, Sonia Levi   +15 more
doaj   +1 more source

Differential Timing and Coordination of Neurogenesis and Astrogenesis in Developing Mouse Hippocampal Subregions

Brain Sciences, 2020
Neocortical development has been extensively studied and therefore is the basis of our understanding of mammalian brain development. One fundamental principle of neocortical development is that neurogenesis and gliogenesis are temporally segregated ...
Allison M. Bond, Daniel A. Berg, Stephanie Lee, Alan S. Garcia-Epelboim, Vijay S. Adusumilli, Guo-li Ming, Hongjun Song   +6 more
doaj   +1 more source

QUANTITATIVE ASSESSMENT OF THE ANGULAR BUNDLE IN ALZHEIMER'S DISEASE

IBRO Neuroscience Reports, 2023
Sandra Cebada Sánchez, José Carlos Delgado González, José Florensa-Vila, Carlos De La Rosa-Prieto, Juan Raspeño Garcia, Rubén Rico-Sánchez, Ricardo Insausti, Emilio Artacho-Pérula   +7 more
doaj   +1 more source

Enhanced Dentate Neurogenesis after Brain Injury Undermines Long-Term Neurogenic Potential and Promotes Seizure Susceptibility

Stem Cell Reports, 2017
Hippocampal dentate gyrus is a focus of enhanced neurogenesis and excitability after traumatic brain injury. Increased neurogenesis has been proposed to aid repair of the injured network.
Eric J. Neuberger, Bogumila Swietek, Lucas Corrubia, Anagha Prasanna, Vijayalakshmi Santhakumar   +4 more
doaj   +1 more source

Beyond amyloid and tau: rethinking Alzheimer’s disease through less explored avenues

Open Biology
Neurodegenerative diseases, particularly Alzheimer’s disease (AD), pose a significant challenge in ageing populations. Our current understanding indicates that the onset of toxic amyloid and tau protein pathologies initiates disease progression. However,
M. Gyimesi, R. K. Okolicsanyi, L. M. Haupt   +2 more
doaj   +1 more source

Caffeic acid protects against l-methionine induced reduction in neurogenesis and cognitive impairment in a rat model

Heliyon
l-methionine (L-met) is a substantial non-polar amino acid for normal development. L-met is converted to homocysteine that leads to hyperhomocysteinemia and subsequent excessive homocysteine in serum resulting in stimulating oxidative stress and vascular
Apiwat Sirichoat, Oabnithi Dornlakorn, Rasa Saenno, Anusara Aranarochana, Nataya Sritawan, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat   +7 more
doaj   +1 more source

Exposure to Patterned Auditory Stimuli during Acute Stress Prevents Despair-Like Behavior in Adult Mice That Were Previously Housed in an Enriched Environment in Combination with Auditory Stimuli

Neural Plasticity, 2018
Several interventions have been shown to counteract the effects of stress that may be related to improved neuroplasticity and neuronal activation. In this sense, environmental enrichment (ENR) protects against acute stress and increases neuroplasticity ...
Enrique Flores-Gutiérrez, Edith Araceli Cabrera-Muñoz, Nelly Maritza Vega-Rivera, Leonardo Ortiz-López, Gerardo Bernabé Ramírez-Rodríguez   +4 more
doaj   +1 more source

Alzheimer’s disease and Hippocampal Adult Neurogenesis; Exploring Shared Mechanisms

Frontiers in Neuroscience, 2016
New neurons incorporate into the granular cell layer of the dentate gyrus throughout life. Neurogenesis is modulated by behavior and plays a major role in hippocampal plasticity.
Orly eLazarov, Carolyn eHollands, Nancy eBartolotti   +2 more
doaj   +1 more source