Results 41 to 50 of about 218,517 (358)
Adult Neurogenesis in Drosophila
Cell Reports, 2013 Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain.
Fernández-Hernández Ismael +2 more
openaire +6 more sources
Autoregulation of Neurogenesis by GDF11 [PDF]
Neuron, 2003 In the olfactory epithelium (OE), generation of new neurons by neuronal progenitors is inhibited by a signal from neurons themselves. Here we provide evidence that this feedback inhibitory signal is growth and differentiation factor 11 (GDF11). Both GDF11 and its receptors are expressed by OE neurons and progenitors, and GDF11 inhibits OE neurogenesis ...
Wu, Hsiao-Huei +6 more
openaire +5 more sources
Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells
Stem Cells International, 2012 The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain. Recently, amniotic fluid (AF) cells have received a lot of attention as an alternative source of stem cells for cell-based therapies.
Anna Jezierski +6 more
doaj +1 more source
Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis [PDF]
arXiv, 2021 Exposures to a hypomagnetic field can affect biological processes. Recently, it has been observed that hypomagnetic field exposure can adversely affect adult hippocampal neurogenesis and hippocampus-dependent cognition in mice. In the same study, the role of reactive oxygen species (ROS) in hypomagnetic field effects has been demonstrated. However, the
arxiv
Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells
Cell Reports, 2015 During cerebellar development, the main portion of the cerebellar plate neuroepithelium gives birth to Purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at its dorsal edge, generates granule cells and cerebellar nuclei neurons ...
Keiko Muguruma +4 more
doaj +1 more source
Development, 2014 A unique feature of humans is the complexity of our central nervous system. A fully functional brain requires that billions of neurons make specific contacts in a highly coordinated way, an issue that is still not well understood. The neural retina constitutes an excellent system with which to analyze key aspects of neurogenesis and circuit formation ...
Lázaro, Centanin, Joachim, Wittbrodt
openaire +2 more sources
Local and regional heterogeneity underlying hippocampal modulation of cognition and mood. [PDF]
, 2014 While the hippocampus has been classically studied for its role in learning and memory, there is significant support for a role of the HPC in regulating emotional behavior.
Jimenez, Jessica C +2 more
core +2 more sources
Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus
The Anatomical Record, Volume 306, Issue 1, Page 162-175, January 2023., 2023 Abstract An adverse maternal environment (AME) and Western diet (WD) in early life predispose offspring toward cognitive impairment in humans and mice. Cognitive impairment associates with hippocampal dysfunction. An important regulator of hippocampal function is the hippocampal Nociceptin/Orphanin FQ (N/OFQ) system. Previous studies find links between
Xingrao Ke +5 more
wiley +1 more source
Vulnerability of Purkinje Cells Generated from Spinocerebellar Ataxia Type 6 Patient-Derived iPSCs
Cell Reports, 2016 Spinocerebellar ataxia type 6 (SCA6) is a dominantly inherited neurodegenerative disease characterized by loss of Purkinje cells in the cerebellum. SCA6 is caused by CAG trinucleotide repeat expansion in CACNA1A, which encodes Cav2.1, α1A subunit of P/Q ...
Yoshihito Ishida +6 more
doaj +1 more source
Comparative approaches to understanding thyroid hormone regulation of neurogenesis [PDF]
, 2019 Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development, increasing the risk of cognitive disorders.
arxiv +1 more source