Results 21 to 30 of about 177,971 (301)
Frontiers in Aging Neuroscience, 2022 Decline in episodic memory is one of the hallmarks of aging and represents one of the most important health problems facing Western societies. A key structure in episodic memory is the hippocampal formation and the dentate gyrus in particular, as the ...
Muriel Koehl +3 more
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Neurogenesis and Epilepsy [PDF]
Epilepsia, 2010 Abstract Medial temporal lobe epilepsy (mTLE) is a common and often intractable form of epilepsy. Approximately 50 million people suffer from different epilepsies worldwide,1 30%–40% of whom may continue to have poorly controlled seizures despite therapy.2,3 Medial TLE is estimated to be the most common cause of intractable epilepsy in ...
Parent, Jack M., Kron, Michelle M.
openaire +3 more sources
PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism-Like Behaviors via the CCL5-CCR1/5-β-catenin Signaling Axis. [PDF]
Adv Sci (Weinh)Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Duan YY +12 more
europepmc +2 more sources
Development, 2014 A unique feature of humans is the complexity of our central nervous system. A fully functional brain requires that billions of neurons make specific contacts in a highly coordinated way, an issue that is still not well understood. The neural retina constitutes an excellent system with which to analyze key aspects of neurogenesis and circuit formation ...
Lázaro, Centanin, Joachim, Wittbrodt
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H3K36 Methylation in Neural Development and Associated Diseases
Frontiers in Genetics, 2020 Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin.
Mattia Zaghi +3 more
doaj +1 more source
Translational Psychiatry, 2021 The mechanistic target of rapamycin (mTOR) is a ubiquitously expressed kinase that acts through two complexes, mTORC1 and mTORC2, to regulate protein homeostasis, as well as long lasting forms of synaptic and behavioral plasticity. Alteration of the mTOR
Muriel Koehl +4 more
doaj +1 more source
Appetite for Neurogenesis [PDF]
Developmental Cell, 2017 Adult neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ) produce diverse olfactory bulb (OB) neurons. In a recent paper in Science, Paul et al. (2017) show that hypothalamic propiomelanocortin (POMC) neurons innervate the anterior ventral V-SVZ and regulate deep granule interneuron production depending on feeding behavior.
Kristen L, Zuloaga, Sally, Temple
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Neuron’s little helper: the role of primary cilia in neurogenesis [PDF]
, 2019 The generation of new neurons involves a great variety of cell-extrinsic and cell-intrinsic signals. The primary cilium, long regarded as an “evolutionary vestige,” has emerged as an essential signaling hub in many cells, including neural progenitors and
Badano, José L. +2 more
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Hippocampal neurogenesis and antidepressive therapy: shocking relations. [PDF]
, 2014 Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago.
Aigner, Ludwig +15 more
core +1 more source
Absent or low rate of adult neurogenesis in the hippocampus of bats (Chiroptera) [PDF]
, 2007 Bats are the only flying mammals and have well developed navigation abilities for 3D-space. Even bats with comparatively small home ranges cover much larger territories than rodents, and long-distance migration by some species is unique among small ...
Winter, Y +23 more
core +2 more sources