Results 21 to 30 of about 163,501 (312)
Hippocampal neurogenesis and antidepressive therapy: shocking relations. [PDF]
, 2014 Speculations on the involvement of hippocampal neurogenesis, a form of neuronal plasticity, in the aetiology of depression and the mode of action of antidepressive therapies, started to arise more than a decade ago.
Aigner, Ludwig +15 more
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Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]
, 2006 The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
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eLife, 2016 Experiments on fruit flies are shedding new light on the evolution and development of the nervous system in metamorphosing insects.
openaire +3 more sources
Morris Water Maze Learning in Two Rat Strains Increases the Expression of the Polysialylated Form of the Neural Cell Adhesion Molecule in the Dentate Gyrus But Has No Effect on Hippocampal Neurogenesis [PDF]
, 2005 In the current study, the authors investigated whether Morris water maze learning induces alterations in hippocampal neurogenesis or neural cell adhesion molecule (NCAM) polysialylation in the dentate gyrus.
Wallinga, Alinde E., +10 more
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Investigating the role of hippocampal neurogenesis in Alzheimer's disease. [PDF]
, 2022 openNeurogenesis is a form of plasticity that occurs constitutively in the neurogenic niches of the mammalian brain. Immature granule cells arising from adult hippocampal neurogenic niche, contribute to unique brain functions in rodents and recent ...
CIAGHI, SABINA
core
Scientific Reports, 2022 Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians.
Deniz Ozberk +10 more
doaj +1 more source
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
doaj +1 more source
eLife, 2020 Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni +12 more
doaj +1 more source
Dual R-Smads interplay in the regulation of vertebrate neurogenesis [PDF]
, 2014 During neurogenesis, multiple regulatory networks integrate extracellular and intracellular signals to ensure proper final numbers for each neuronal subtype at the end of the developmental process.
Sanz, Adriana L., Miguez Gómez, David
core +1 more source
Cell Reports, 2019 Summary: Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and ...
Angelo Iannielli +9 more
doaj +1 more source