Results 11 to 20 of about 177,971 (301)
Adult Neurogenesis in Drosophila [PDF]
Cell Reports, 2013 Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain.
Fernández-Hernández Ismael +2 more
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Cells, 2022 One of the most intriguing dogmas in neurosciences—the empirical lack of brain neuronal regeneration in adulthood onwards to late life—began to be debunked initially by research groups focused on understanding postnatal (early days/weeks of murine and guinea pigs) neurodevelopmental and neuroplastic events [...]
Andreia Vaz, Inês Ribeiro, Luísa Pinto
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Molecular Brain, 2021 Homer is a postsynaptic scaffold protein, which has long and short isoforms. The long form of Homer consists of an N-terminal target-binding domain and a C-terminal multimerization domain, linking multiple proteins within a complex.
Teiichi Furuichi +6 more
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Chronic treatment with the GLP1 analogue liraglutide increases cell proliferation and differentiation into neurons in an AD mouse model [PDF]
, 2013 Neurogenesis is a life long process, but the rate of cell proliferation and differentiation decreases with age. In Alzheimer's patients, along with age, the presence of Aβ in the brain inhibits this process by reducing stem cell proliferation and cell ...
Parthsarathy, Vadivel +1 more
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Nature Communications, 2022 Dravet syndrome is a devastating epileptic encephalopathy caused by Scn1a gene haploinsufficiency. Exploiting a novel knock-in mouse model, here the authors show that restoring Scn1a expression after symptom onset is sufficient to rescue main phenotypic ...
Nicholas Valassina +13 more
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Neurogenesis or non-neurogenesis: that is the question [PDF]
Journal of Clinical Investigation, 2014 Neural stem/precursor cells (NPCs) that reside within germinal niches of the adult CNS have more complex roles than previously expected. In addition to their well-documented neurogenic functions, emerging evidence indicates that NPCs exert non-neurogenic functions that contribute to the regulation and preservation of tissue homeostasis under both ...
MARTINO , GIANVITO +2 more
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SETD5 haploinsufficiency affects mitochondrial compartment in neural cells
Molecular Autism, 2023 Background Neurodevelopmental disorders (NDDs) are heterogeneous conditions due to alterations of a variety of molecular mechanisms and cell dysfunctions. SETD5 haploinsufficiency leads to NDDs due to chromatin defects.
Mattia Zaghi +12 more
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Rare Does Not Mean Worthless: How Rare Diseases Have Shaped Neurodevelopment Research in the NGS Era
Biomolecules, 2021 The advent of next-generation sequencing (NGS) is heavily changing both the diagnosis of human conditions and basic biological research. It is now possible to dig deep inside the genome of hundreds of thousands or even millions of people and find both ...
Mattia Zaghi +3 more
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Nature Communications, 2021 Schinzel-Giedion syndrome (SGS) is a fatal developmental syndrome characterized by severe intellectual and physical deficits due, at least in part, to early neurodegeneration.
Federica Banfi +16 more
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Metabolism and neurogenesis [PDF]
Current Opinion in Neurobiology, 2017 The generation of neurons in the developing and adult mammalian brain by neural stem/progenitor cells (NSPCs) depends on a tight control of NSPC activity and neuronal differentiation that is regulated by a plethora of intrinsic and extrinsic molecular cues.
Knobloch, Marlen, Jessberger, Sebastian
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