Results 11 to 20 of about 155,428 (262)
Adult Neurogenesis in Drosophila [PDF]
Cell Reports, 2013 Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain.
Fernández Hernández, Ismael +6 more
core +6 more sources
Cells, 2022 One of the most intriguing dogmas in neurosciences—the empirical lack of brain neuronal regeneration in adulthood onwards to late life—began to be debunked initially by research groups focused on understanding postnatal (early days/weeks of murine and guinea pigs) neurodevelopmental and neuroplastic events [...]
Andreia Vaz, Inês Ribeiro, Luísa Pinto
openaire +3 more sources
Neurogenesis or non-neurogenesis: that is the question [PDF]
Journal of Clinical Investigation, 2014 Neural stem/precursor cells (NPCs) that reside within germinal niches of the adult CNS have more complex roles than previously expected. In addition to their well-documented neurogenic functions, emerging evidence indicates that NPCs exert non-neurogenic functions that contribute to the regulation and preservation of tissue homeostasis under both ...
MARTINO , GIANVITO +2 more
openaire +3 more sources
Neurogenesis and Epilepsy [PDF]
Epilepsia, 2010 Abstract Medial temporal lobe epilepsy (mTLE) is a common and often intractable form of epilepsy. Approximately 50 million people suffer from different epilepsies worldwide,1 30%–40% of whom may continue to have poorly controlled seizures despite therapy.2,3 Medial TLE is estimated to be the most common cause of intractable epilepsy in ...
Parent, Jack M., Kron, Michelle M.
openaire +3 more sources
Metabolism and neurogenesis [PDF]
Current Opinion in Neurobiology, 2017 The generation of neurons in the developing and adult mammalian brain by neural stem/progenitor cells (NSPCs) depends on a tight control of NSPC activity and neuronal differentiation that is regulated by a plethora of intrinsic and extrinsic molecular cues.
Knobloch, Marlen, Jessberger, Sebastian
openaire +4 more sources
Development, 2014 A unique feature of humans is the complexity of our central nervous system. A fully functional brain requires that billions of neurons make specific contacts in a highly coordinated way, an issue that is still not well understood. The neural retina constitutes an excellent system with which to analyze key aspects of neurogenesis and circuit formation ...
Lázaro, Centanin, Joachim, Wittbrodt
openaire +2 more sources
Appetite for Neurogenesis [PDF]
Developmental Cell, 2017 Adult neural stem cells (NSCs) in the ventricular-subventricular zone (V-SVZ) produce diverse olfactory bulb (OB) neurons. In a recent paper in Science, Paul et al. (2017) show that hypothalamic propiomelanocortin (POMC) neurons innervate the anterior ventral V-SVZ and regulate deep granule interneuron production depending on feeding behavior.
Kristen L, Zuloaga, Sally, Temple
openaire +2 more sources
eLife, 2016 Experiments on fruit flies are shedding new light on the evolution and development of the nervous system in metamorphosing insects.
openaire +3 more sources
Neurodegeneration and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]
, 2003 As the proportion of senior citizens gradually increases, the behavioral changes that occur with normal aging and as a consequence of Alzheimer’s disease (AD) will afflict many of us in the future.
Bondolfi, Luca E.
core +1 more source
Epilepsy and Adult Neurogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial temporal lobe epilepsy (mTLE) affect multiple steps in the developmental course from the dividing neural stem cell to the migrating and integrating newborn neuron. Furthermore,
Jessberger, Sebastian, Parent, Jack M
openaire +2 more sources