Results 31 to 40 of about 177,971 (301)
Disc 1 and neurogenesis in schizophrenia and other major psychiatric disorders : a post-mortem study of the human hippocampus [PDF]
, 2013 Psychiatric illnesses are disorders that affect millions worldwide. Evidence from quantitative and molecular genetics analysis suggests a strong genetic component to these disorders.
Oladimeji, Paul Babajide
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Frontiers in Cell and Developmental Biology, 2021 TBL1XR1 gene is associated with multiple developmental disorders presenting several neurological aspects. The relative protein is involved in the modulation of important cellular pathways and master regulators of transcriptional output, including nuclear
Giuseppina Mastrototaro +19 more
doaj +1 more source
eLife, 2016 Experiments on fruit flies are shedding new light on the evolution and development of the nervous system in metamorphosing insects.
openaire +3 more sources
Neural stem cell biology and neurogenesis in mouse models of aging and Alzheimer's disease [PDF]
, 2006 The etiology of Alzheimer’s disease (AD) remains a great challenge for neurological research. Extensive investigations for almost one hundred years have led to profound insights of the pathological and molecular mechanisms that affect the AD brain, and
Ermini, Florian V.
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Dual R-Smads interplay in the regulation of vertebrate neurogenesis [PDF]
, 2014 During neurogenesis, multiple regulatory networks integrate extracellular and intracellular signals to ensure proper final numbers for each neuronal subtype at the end of the developmental process.
Sanz, Adriana L., Miguez Gómez, David
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Direct Neuronal Reprogramming Reveals Unknown Functions for Known Transcription Factors
Frontiers in Neuroscience, 2019 In recent years, the need to derive sources of specialized cell types to be employed for cell replacement therapies and modeling studies has triggered a fast acceleration of novel cell reprogramming methods.
Gaia Colasante +5 more
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Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
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Cell Reports, 2019 Summary: Stem cell-derived neurons are generally obtained in mass cultures that lack both spatial organization and any meaningful connectivity. We implement a microfluidic system for long-term culture of human neurons with patterned projections and ...
Angelo Iannielli +9 more
doaj +1 more source
eLife, 2020 Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni +12 more
doaj +1 more source
Scientific Reports, 2022 Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians.
Deniz Ozberk +10 more
doaj +1 more source