Results 31 to 40 of about 174,681 (296)
eLife, 2020 Rett syndrome is an incurable neurodevelopmental disorder caused by mutations in the gene encoding for methyl-CpG binding-protein 2 (MeCP2). Gene therapy for this disease presents inherent hurdles since MECP2 is expressed throughout the brain and its ...
Mirko Luoni +12 more
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Scientific Reports, 2022 Opioids are the therapeutic agents of choice to manage moderate to severe pain in patients with advanced cancer, however the unpredictable inter-individual response to opioid therapy remains a challenge for clinicians.
Deniz Ozberk +10 more
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Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells
Stem Cells International, 2012 The usage of stem cells is a promising strategy for the repair of damaged tissue in the injured brain. Recently, amniotic fluid (AF) cells have received a lot of attention as an alternative source of stem cells for cell-based therapies.
Anna Jezierski +6 more
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Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition
Nature Communications, 2023 Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering with the net charges of the nucleosomes, is a key player in this regulation.
Mattia Zaghi +22 more
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eLife, 2023 The rubella virus can interfere with fetal brain development by infecting immune cells called microglia during pregnancy.
Ekaterina Epifanova, Laurent Nguyen
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Performance on a pattern separation task by Alzheimer's patients shows possible links between disrupted dentate gyrus activity and apolipoprotein E is an element of 4 status and cerebrospinal fluid amyloid-beta 42 levels [PDF]
, 2014 Introduction: Emerging evidence suggests that decreased adult hippocampal neurogenesis represents an early critical event in the course of Alzheimer's disease (AD).
Annas, Peter +14 more
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The EMBO Journal, 2023 Lifelong hippocampal neurogenesis is maintained by a pool of multipotent adult neural stem cells (aNSCs) residing in the subgranular zone of the dentate gyrus (DG).
Oier Pastor-Alonso +11 more
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Epilepsy and Adult Neurogenesis [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Seizure activity in the hippocampal region strongly affects stem cell-associated plasticity in the adult dentate gyrus. Here, we describe how seizures in rodent models of mesial temporal lobe epilepsy (mTLE) affect multiple steps in the developmental course from the dividing neural stem cell to the migrating and integrating newborn neuron. Furthermore,
Jessberger, Sebastian, Parent, Jack M
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Neurobiology of Disease, 2009 In recent years, GDNF has emerged as a protective and restorative agent in several models of neurodegeneration; however, the exact molecular mechanisms responsible for these effects are not yet fully understood. Here we examined the effects of astrocytes
Jagdeep K. Sandhu +8 more
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Frontiers in Cellular Neuroscience, 2022 The adult neurogenic niches are complex multicellular systems, receiving regulatory input from a multitude of intracellular, juxtacrine, and paracrine signals and biological pathways. Within the niches, adult neural stem cells (aNSCs) generate astrocytic
Amber Penning +7 more
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