Results 41 to 50 of about 238,754 (299)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Reduction of adult hippocampal neurogenesis modifies brain functional connectivity and enhances cocaine-seeking in mice [PDF]

, 2015
Recently, adult hippocampal neurogenesis has been proposed as a putative neuroplastic mechanism involved in those behavioural processes. In this work, we studied the effect of the inhibition of adult hippocampal neurogenesis using the DNA alkylating ...
Blanco, Eduardo, Castilla-Ortega, Estela, Estivill-Torrús, Guillermo, Ladrón de Guevara-Miranda, David, Pavón, Francisco, Pedraz, María, Rodriguez de Fonseca, Fernando, Santin-Nuñez, Luis Javier, Serrano, Antonia   +8 more
core  

Metabolism and neurogenesis [PDF]

Current Opinion in Neurobiology, 2017
The generation of neurons in the developing and adult mammalian brain by neural stem/progenitor cells (NSPCs) depends on a tight control of NSPC activity and neuronal differentiation that is regulated by a plethora of intrinsic and extrinsic molecular cues.
Knobloch, Marlen, Jessberger, Sebastian
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Self-Organization of Polarized Cerebellar Tissue in 3D Culture of Human Pluripotent Stem Cells

Cell Reports, 2015
During cerebellar development, the main portion of the cerebellar plate neuroepithelium gives birth to Purkinje cells and interneurons, whereas the rhombic lip, the germinal zone at its dorsal edge, generates granule cells and cerebellar nuclei neurons ...
Keiko Muguruma, Ayaka Nishiyama, Hideshi Kawakami, Kouichi Hashimoto, Yoshiki Sasai   +4 more
doaj   +1 more source

Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke. [PDF]

, 2019
Stroke is the leading cause of adult disability. Neurogenesis after stroke is associated with repair; however, the mechanisms regulating poststroke neurogenesis and its functional effect remain unclear. Here, we investigate multiple mechanistic routes of
Carmichael, S Thomas, Gleichman, Amy, Liang, Huixuan, Machnicki, Michal, Rshtouni, Mary, Ruddell, Jack, Tang, Sydney, Telang, Sagar, Zhao, Handi   +8 more
core   +1 more source

Molecular mechanisms of neurogenic aging in the adult mouse subventricular zone [PDF]

, 2019
In the adult rodent brain, the continuous production of new neurons by neural stem/progenitor cells (NSPCs) residing in specialized neurogenic niches and their subsequent integration into pre-existing cerebral circuitries supports odour discrimination ...
Biagioni, Stefano, Cacci, Emanuele, Gioia, Roberta, Lupo, Giuseppe, Nisi, PAOLA SERENA   +4 more
core   +1 more source

A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]

, 2020
Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo, A Kamezaki, A Torroglosa, AC Newton, AC Rice, AX Wu-Zhang, BT Susarla, C Kilkenny, C Romero-Grimaldi, CP Blobel, DC Lee, DR Marks, E Flores-Giubi, EK Adrian Jr., ES Anton, F Doetsch, F Garcia-Bernal, FH Gage, GJ Francis, HG Kuhn, HT Ghashghaei, I Comte, J Fallon, J Liu, J Wang, JB Cavanagh, JC McGrath, JM Verdi, K Blennow, K Jin, L Avila, LG Rabaneda, LG Rabaneda, M Carrasco, M Dang, M Dang, M Fatt, M Murillo-Carretero, N Geribaldi-Doldan, N Geribaldi-Doldan, ND Zhao, O Gonzalez-Perez, PK Dash, RG Thorne, S Chirumamilla, S Dominguez-Garcia, SW Sunnarborg, V Tropepe, Y Kim   +48 more
core   +2 more sources

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Neurogenesis and astrogenesis contribute to vestibular compensation in the neurectomized adult cat: cellular and behavioral evidence [PDF]

, 2009
Neurogenesis occurs in some regions of the adult mammalian brain and gives rise to neurons integrated into functional networks. In pathological or postlesional conditions, neurogenesis and astrogenesis can also occur, as demonstrated in the deafferented ...
Brahim Tighilet, Jacques Leonard, Jean Michel Brezun, Michel Lacour, Sophie Dutheil   +4 more
core   +1 more source