Results 101 to 110 of about 16,632 (221)

Central Nervous System Involvement as the Initial Manifestation of Transthyretin Amyloidosis: A Case Report and Literature Review

open access: yesiRADIOLOGY, Volume 3, Issue 5, Page 388-396, October 2025.
We reported a patient who presented with transient focal neurological symptoms. The contrast‐enhanced brain magnetic resonance imaging (MRI) of this patient demonstrated significant enhancement of the dura mater, pia mater, and spinal meninges. Based on the positive result of single photon emission computed tomography (SPECT), we promptly determined ...
Fen Li   +6 more
wiley   +1 more source

Decreased Noradrenaline (Norepinephrine) Synthesis in Neurogenic Orthostatic Hypotension [PDF]

open access: yesCirculation, 1968
Three patients with idiopathic orthostatic (postural) hypotension were infused over a 4-hr period with 104.6 µc of 3-hydroxytyramine-2- 14 C, the immediate precursor in the synthesis of the sympathetic neurohormone, that is, noradrenaline (norepinephrine).
M C, Goodall, W R, Harlan, H, Alton
openaire   +2 more sources

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

open access: yesMovement Disorders Clinical Practice, Volume 12, Issue 10, Page 1609-1614, October 2025.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan   +4 more
wiley   +1 more source

The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 9, Page 1823-1833, September 2025.
ABSTRACT Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to distinguish MSA from related disorders and monitor disease progression. Methods Seventeen participants with an
Paula Trujillo   +11 more
wiley   +1 more source

Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent‐Onset Cognitive Impairment

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 9, Page 1919-1925, September 2025.
ABSTRACT Immunofluorescence for phosphorylated alpha‐synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent‐onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow‐up clinical re‐evaluation.
Alessandro Furia   +13 more
wiley   +1 more source

Longitudinal Trajectory of Multimodal Markers in a Patient with Isolated REM Sleep Behavior Disorder

open access: yes
Movement Disorders, Volume 40, Issue 12, Page 2842-2844, December 2025.
Seohee Choi   +7 more
wiley   +1 more source

Assessing the Skeletal Muscle Pump During Lower Limb Counterpressure: Lags and Causality in Cardiovascular Regulation

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 4, August 2025.
ABSTRACT Background Orthostatic hypotension (OH) is a prevalent condition among older adults, characterised by a sudden drop in blood pressure upon standing, often leading to dizziness and increased risk of falls, morbidity and mortality. The skeletal muscle pump is thought to be important in maintaining venous return and stabilising blood pressure ...
Silvin P. Knight   +3 more
wiley   +1 more source

Characteristics, Management, and Outcomes of Hospitalized Patients with Orthostatic Hypotension

open access: yesThe Journal of Clinical Hypertension, Volume 27, Issue 8, August 2025.
ABSTRACT Orthostatic hypotension (OH) is a common inpatient condition associated with falls, syncope, and mortality. However, standardized approaches for inpatient management of OH are lacking and may vary across clinical specialties. In this retrospective observational cohort study, we reviewed the electronic medical records of patients admitted to ...
Benjamin A. Wagner   +5 more
wiley   +1 more source

Fix or Adapt? Rethinking the Management of Complex Autonomic Dysfunction in an Older Adult Following Orthopedic Surgery

open access: yes
Geriatrics &Gerontology International, Volume 25, Issue 12, Page 1962-1964, December 2025.
Calvin D. De Louche   +1 more
wiley   +1 more source

Neurogenic Shock [PDF]

open access: yes, 2019
Neurogenic shock is a state characterized by hypotension, bradycardia, and other evidence of autonomic dysfunction. The most common cause is acute spinal cord injury (SCI), which will be the subject of our focus.
Ackerman, Daniel J., Volski, Anna
core   +1 more source

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