Results 81 to 90 of about 4,737 (214)

Deceleration Capacity as a Marker of Autonomic Cardiac Modulation in Prodromal and Manifest Parkinson's Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

European Journal of Neurology, Volume 32, Issue 11, November 2025.
Objective: Heart rate variability (HRV) is a promising tool for autonomic dysfunction assessment, especially Deceleration capacity (DC), a sensitive parasympathetic marker. M&M: Study in patients with isolated REM sleep behavior disorder, Parkinson's disease, multiple system atrophy, and supranuclear palsy as compared to healthy control subjects ...
Elisabeth Ruppert, Nuria Mix, Karl Kesper, Axel Bauer, David Vadasz, Vincent Ries, Elisabeth Sittig, Ulrich Koehler, Annette Janzen, Wolfgang H. Oertel   +9 more
wiley   +1 more source

Idiopathic orthostatic hypotension: Recent data (eleven cases) and review of the literature [PDF]

Eight cases of Shy-Drager syndrome and three of Bradbury-Eggleston idiopathic orthostatic hypotension were examined. In all cases, examination of circulatory reflexes showed major dysfunction of the sympathetic vasoconstrictor system.
Annat, G., Boisson, D., Devic, M., Holzhapfel, L., Levrat, R., Michel, D., Ninet, J., Peyrin, L., Schott, B., Vincent, M.   +9 more
core   +1 more source

Safety and Durability of Effect with Long-Term, Open-Label Droxidopa Treatment in Patients with Symptomatic Neurogenic Orthostatic Hypotension (NOH303)

Journal of Parkinson’s Disease, 2016
Background: Neurogenic orthostatic hypotension (nOH) is associated with insufficient norepinephrine release in response to postural change. Objective: The objective of this study was to evaluate the long-term safety and durability of efficacy of the ...
Stuart Isaacson, Holly A. Shill, Steven Vernino, Adam Ziemann, Gerald J. Rowse   +4 more
doaj   +1 more source

2198 Cognitive and behavioral side effects in patients treated with droxidopa for neurogenic orthostatic hypotension

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: To describe adverse behavioral symptoms attributed to droxidopa therapy for neurogenic orthostatic hypotension (nOH). METHODS/STUDY POPULATION: BACKGROUND: Droxidopa, a norepinephrine (NE) precursor, improves symptoms of nOH by ...
Katherine McDonell, Cyndya Shibao, Italo Biaggioni, David Robertson, Daniel Claassen   +4 more
doaj   +1 more source

Central Nervous System Involvement as the Initial Manifestation of Transthyretin Amyloidosis: A Case Report and Literature Review

iRADIOLOGY, Volume 3, Issue 5, Page 388-396, October 2025.
We reported a patient who presented with transient focal neurological symptoms. The contrast‐enhanced brain magnetic resonance imaging (MRI) of this patient demonstrated significant enhancement of the dura mater, pia mater, and spinal meninges. Based on the positive result of single photon emission computed tomography (SPECT), we promptly determined ...
Fen Li, Mingsheng Wan, Benjian Sun, Lijia Zou, Huan Yang, Jing Li, Si Chen   +6 more
wiley   +1 more source

STOPPFrail [Screening Tool of Older Persons Prescriptions in Frail adults with limited life expectancy]: Consensus validation [PDF]

, 2016
Objective: To validate STOPPFrail, a list of explicit criteria for potentially inappropriate medication (PIM) use in frail older adults with limited life expectancy.Design: A Delphi consensus survey of an expert panel comprising academic geriatricians ...
Gallagher, Paul, Hanora Lavan, Amanda, O'Mahony, Denis, Parsons, Carole   +3 more
core   +1 more source

Investigating Dopamine Replacement–Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease

Movement Disorders Clinical Practice, Volume 12, Issue 10, Page 1609-1614, October 2025.
Abstract Background Non‐motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD. Objective The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.
Abhimanyu Mahajan, Christopher B. Morrow, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone   +4 more
wiley   +1 more source

The MSA Atrophy Index (MSA‐AI): An Imaging Marker for Diagnosis and Clinical Progression in Multiple System Atrophy

Annals of Clinical and Translational Neurology, Volume 12, Issue 9, Page 1823-1833, September 2025.
ABSTRACT Objective Reliable biomarkers are essential for tracking disease progression and advancing treatments for multiple system atrophy (MSA). In this study, we propose the MSA Atrophy Index (MSA‐AI), a novel composite volumetric measure to distinguish MSA from related disorders and monitor disease progression. Methods Seventeen participants with an
Paula Trujillo, Kilian Hett, Amy Cooper, Amy E. Brown, Jessica Iregui, Manus J. Donahue, M. Erik Landman, Italo Biaggioni, Margaret Bradbury, Cynthia Wong, David Stamler, Daniel O. Claassen   +11 more
wiley   +1 more source

Midodrine as a Countermeasure to Orthostatic Hypotension Immediately After Space Shuttle Landing [PDF]

Midodrine prevents post-space flight orthostatic intolerance when testing is conducted in a controlled laboratory setting within 2-4 hours after Space Shuttle landing.
Lee, Stuart M. C., Platts, Steven H., Ribeiro, L. Christine, Stenger, Michael B.   +3 more
core   +1 more source

Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database

Frontiers in Neurology
PurposeTo explore the frequency of orthostatic hypotension (OH) in a large sample of amyotrophic lateral sclerosis patients (ALS).MethodsFrom the PRO-ACT database, data of 1,240 ALS patients were analyzed, focusing on blood pressure and heart rate before
C. Quarracino, F. Capani, F. Capani, M. Otero-Losada, G. E. Rodríguez, S. Pérez-Lloret, S. Pérez-Lloret   +6 more
doaj   +1 more source