Results 1 to 10 of about 135,205 (333)

Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia

Frontiers in Molecular Neuroscience, 2023
Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circuitry ...
Julien Gasser, Gaelle Gillet, Jorge S. Valadas, Laura Rouvière, Apoorva Kotian, Wenqiang Fan, James Keaney, Irena Kadiu   +7 more
doaj   +1 more source

Divergent functional outcomes of NLRP3 blockade downstream of multi-inflammasome activation: therapeutic implications for ALS

Frontiers in Immunology, 2023
NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death.
Marie-Laure Clénet, James Keaney, Gaëlle Gillet, Jorge S. Valadas, Julie Langlois, Alvaro Cardenas, Julien Gasser, Irena Kadiu   +7 more
doaj   +1 more source

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease

Scientific Reports, 2021
Microglial cells are affected in Alzheimer’s disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory loss, depression is common in patients with AD.
Martina Svensson, Gustaf Olsson, Yiyi Yang, Sara Bachiller, Maria Ekemohn, Joakim Ekstrand, Tomas Deierborg   +6 more
doaj   +1 more source

Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome

Scientific Reports, 2021
The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2 ...
Katharina Cosker, Anna Mallach, Janhavi Limaye, Thomas M. Piers, James Staddon, Stephen J. Neame, John Hardy, Jennifer M. Pocock   +7 more
doaj   +1 more source

An engineered Fc fusion protein that targets antigen-specific T cells and autoantibodies mitigates autoimmune disease

Journal of Neuroinflammation, 2023
Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T and B cell effector functions ...
Mathangi Janakiraman, Alexei Leliavski, Jeeva Varadarajulu, Dieter Jenne, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

Journal of Neuroinflammation, 2020
Background Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Daniel N. Cox, Javier E. Stern   +6 more
doaj   +1 more source

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation

Journal of Neuroinflammation, 2021
Background Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain’s immune response, plays an important role in aged associated degeneration of central nervous ...
Andrés Fernández, Elena Quintana, Patricia Velasco, Belén Moreno-Jimenez, Belén de Andrés, Maria Luisa Gaspar, Isabel Liste, Marçal Vilar, Helena Mira, Eva Cano   +9 more
doaj   +1 more source

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

Frontiers in Cellular Neuroscience, 2018
Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization,
Sara Bachiller, Itzia Jiménez-Ferrer, Agnes Paulus, Yiyi Yang, Maria Swanberg, Tomas Deierborg, Antonio Boza-Serrano   +6 more
doaj   +1 more source

Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue

Cells, 2022
The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known.
Mario Martínez-Torija, Pedro F. Esteban, Francisco Javier Espino-Rodríguez, Beatriz Paniagua-Torija, Eduardo Molina-Holgado, Silvia Ceruelo, Gemma Barroso-Garcia, Alba G. Arandilla, Luis F. Lopez-Almodovar, Angel Arevalo-Martin, Juan Antonio Moreno, Daniel Garcia-Ovejero, Mª Carmen Durán-Ruiz, Rafael Moreno-Luna   +13 more
doaj   +1 more source

Correction to: Three-dimensional morphometric analysisreveals time-dependent structural changesin microglia and astrocytes in the centralamygdala and hypothalamicparaventricular nucleus of heart failure rats

Journal of Neuroinflammation, 2020
An amendment to this paper has been published and can be accessed via the original article.
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox, Javier E. Stern   +7 more
doaj   +1 more source