NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]
International Journal of Biological Macromolecules 246 (2023)
125609, 2023 The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv +1 more source
Catalytically Potent and Selective Clusterzymes for Modulation of Neuroinflammation Through Single-Atom Substitutions [PDF]
Nature Communications,2020, 2020 Emerging artificial enzymes with reprogrammed and augmented catalytic activity and substrate selectivity have long been pursued with sustained efforts. The majority of current candidates rely on noble metals or transition metal oxides with rather poor catalytic activity compared with natural molecules.
arxiv +1 more source
Autism spectrum disorder: a neuro-immunometabolic hypothesis of the developmental origins [PDF]
Biology 2023, 2019 Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes and microglia, among the brain's non-neuronal glia cell populations, play a pivotal role in neurodevelopment, predisposition to and initiation of disease throughout lifespan.
arxiv +1 more source
Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood [PDF]
Neurosci Biohav Rev 2019, 2019 We review evidence supporting the role of early life programming in the susceptibility for adult neurodegenerative diseases while highlighting questions and proposing avenues for future research to advance our understanding of this fundamental process.
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Alpha7 nicotinic acetylcholine receptor signaling modulates ovine fetal brain astrocytes transcriptome in response to endotoxin [PDF]
Front. Immunol. 2019, 2018 Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on alpha7 nicotinic acetylcholine receptor (alpha7nAChR) in fetal astrocytes
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Meta-analysis for Discovering Which Genes are Differentially Expressed in Neuroinflammation [PDF]
arXiv, 2022 Neuroinflammation is a significant aspect of many neurological diseases of Homo sapiens, and the genes that are differentially expressed in this process should be well understood to gather the nature of such diseases. We have conducted a meta-analysis (based on a combined adjusted P value and logFC scheme) of 6 multi-species (Homo sapiens, Mus musculus)
arxiv
In Silico Prediction of Blood-Brain Barrier Permeability of Chemical Compounds through Molecular Feature Modeling [PDF]
arXiv, 2022 The introduction of computational techniques to analyze chemical data has given rise to the analytical study of biological systems, known as "bioinformatics". One facet of bioinformatics is using machine learning (ML) technology to detect multivariable trends in various cases.
arxiv
Perivascular Spaces Segmentation in Brain MRI Using Optimal 3D Filtering [PDF]
, 2017 Perivascular Spaces (PVS) are a recently recognised feature of Small Vessel Disease (SVD), also indicating neuroinflammation, and are an important part of the brain's circulation and glymphatic drainage system. Quantitative analysis of PVS on Magnetic Resonance Images (MRI) is important for understanding their relationship with neurological diseases ...
arxiv +1 more source
Diffusion-weighted MR spectroscopy: consensus, recommendations and resources from acquisition to modelling [PDF]
arXiv, 2023 Brain cell structure and function reflect neurodevelopment, plasticity and ageing, and changes can help flag pathological processes such as neurodegeneration and neuroinflammation. Accurate and quantitative methods to non-invasively disentangle cellular structural features are needed and are a substantial focus of brain research.
arxiv
Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury [PDF]
arXiv, 2022 Traumatic brain injury is a global public health problem associated with chronic neurological complications and long-term disability. Biomarkers that map onto the underlying brain pathology driving these complications are urgently needed to identify individuals at risk for poor recovery and to inform design of clinical trials of neuroprotective ...
arxiv