Results 11 to 20 of about 308,337 (381)
Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function [PDF]
, 2014 Cancer patients frequently suffer from fatigue, a complex syndrome associated with loss of muscle mass, weakness, and depressed mood. Cancer-related fatigue (CRF) can be present at the time of diagnosis, during treatment, and persists for years after ...
Diana M. Norden +8 more
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The effects of microglia-associated neuroinflammation on Alzheimer’s disease
Frontiers in Immunology, 2023 Alzheimer’s disease (AD) is defined as a severe chronic degenerative neurological disease in human. The pathogenic mechanism of AD has been convincingly elucidated by the “amyloid cascade hypothesis” with the main focus of the pathological accretion of β-
Cuicui Wang +7 more
semanticscholar +1 more source
Brain, Behavior, & Immunity - Health, 2020 Early life adversities during childhood (such as maltreatment, abuse, neglect, or parental deprivation) may increase the vulnerability to cognitive disturbances and emotional disorders in both, adolescence and adulthood.
S. Bachiller +4 more
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Scientific Reports, 2021 Microglial cells are affected in Alzheimer’s disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory loss, depression is common in patients with AD.
Martina Svensson +6 more
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Journal of Neuroinflammation, 2023 Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T and B cell effector functions ...
Mathangi Janakiraman +4 more
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Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis
Journal of Neuroinflammation, 2023 As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients.
Anbiao Wu, Jiyan Zhang
semanticscholar +1 more source
Cannabinoids and neuroinflammation [PDF]
British Journal of Pharmacology, 2004 Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti‐inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti‐inflammatory effects of cannabinoids obtained using ...
Lisa, Walter, Nephi, Stella
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Scientific Reports, 2021 The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2 ...
Katharina Cosker +7 more
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Molecular Mechanisms of Neuroinflammation in Aging and Alzheimer’s Disease Progression
International Journal of Molecular Sciences, 2023 Aging is the most prominent risk factor for late-onset Alzheimer’s disease. Aging associates with a chronic inflammatory state both in the periphery and in the central nervous system, the evidence thereof and the mechanisms leading to chronic ...
F. Andronie-Cioara +6 more
semanticscholar +1 more source
RIPped for neuroinflammation [PDF]
Cell Research, 2017 Activation of the receptor interacting serine/threonine kinase (RIPK) 3 mediates an inflammatory type of cell death called necroptosis; in addition, RIPK3 has necroptosis-independent roles in inflammation, although these are not well defined. In a recent study published in Cell, Daniels and colleagues demonstrate that RIPK3 controls West Nile virus ...
Bart, Tummers, Douglas R, Green
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