Results 11 to 20 of about 212,554 (299)
Frontiers in Molecular Neuroscience, 2023 Huntington’s disease (HD) is an inherited autosomal dominant neurodegenerative disease caused by CAG repeats in exon 1 of the HTT gene. A hallmark of HD along with other psychiatric and neurodegenerative diseases is alteration in the neuronal circuitry ...
Julien Gasser +7 more
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Frontiers in Immunology, 2023 NOD-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome modulation has emerged as a potential therapeutic approach targeting inflammation amplified by pyroptotic innate immune cell death.
Marie-Laure Clénet +7 more
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Role of neuroinflammation in neurodegeneration development
Signal Transduction and Targeted Therapy, 2023 Studies in neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease and Amyotrophic lateral sclerosis, Huntington’s disease, and so on, have suggested that inflammation is not only a result of neurodegeneration but also a crucial ...
Weifeng Zhang +3 more
semanticscholar +1 more source
Frontiers in Psychiatry, 2023 In a subset of patients, chronic exposure to stress is an etiological risk factor for neuroinflammation and depression. Neuroinflammation affects up to 27% of patients with MDD and is associated with a more severe, chronic, and treatment-resistant ...
Sameer Hassamal
semanticscholar +1 more source
Tau and neuroinflammation in Alzheimer’s disease: interplay mechanisms and clinical translation
Journal of Neuroinflammation, 2023 Alzheimer’s Disease (AD) contributes to most cases of dementia. Its prominent neuropathological features are the extracellular neuritic plaques and intercellular neurofibrillary tangles composed of aggregated β-amyloid (Aβ) and hyperphosphorylated tau ...
Yijun Chen, Yang Yu
semanticscholar +1 more source
Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
Translational Psychiatry, 2023 Mood disorders are associated with elevated inflammation, and the reduction of symptoms after multiple treatments is often accompanied by pro-inflammation restoration.
Bingqi Guo +5 more
semanticscholar +1 more source
Brain, Behavior, & Immunity - Health, 2020 Early life adversities during childhood (such as maltreatment, abuse, neglect, or parental deprivation) may increase the vulnerability to cognitive disturbances and emotional disorders in both, adolescence and adulthood.
S. Bachiller +4 more
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Scientific Reports, 2021 Microglial cells are affected in Alzheimer’s disease (AD) and interact with amyloid-beta (Aβ) plaques. Apart from memory loss, depression is common in patients with AD.
Martina Svensson +6 more
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Journal of Neuroinflammation, 2023 Current effective therapies for autoimmune diseases rely on systemic immunomodulation that broadly affects all T and/or B cell responses. An ideal therapeutic approach would combine autoantigen-specific targeting of both T and B cell effector functions ...
Mathangi Janakiraman +4 more
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Microglia Mediated Neuroinflammation in Parkinson’s Disease
Cells, 2023 Parkinson’s Disease (PD) is the second most common neurodegenerative disorder seen, especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance and coordination are among the hallmarks, and dopaminergic neuronal loss in ...
Sevim Isik +4 more
semanticscholar +1 more source