Results 21 to 30 of about 212,554 (299)
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
Translational Neurodegeneration, 2020 Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
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The effects of microglia-associated neuroinflammation on Alzheimer’s disease
Frontiers in Immunology, 2023 Alzheimer’s disease (AD) is defined as a severe chronic degenerative neurological disease in human. The pathogenic mechanism of AD has been convincingly elucidated by the “amyloid cascade hypothesis” with the main focus of the pathological accretion of β-
Cuicui Wang +7 more
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Scientific Reports, 2021 The R47H variant of the microglial membrane receptor TREM2 is linked to increased risk of late onset Alzheimer’s disease. Human induced pluripotent stem cell derived microglia (iPS-Mg) from patient iPSC lines expressing the AD-linked R47Hhet TREM2 ...
Katharina Cosker +7 more
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An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases
International Journal of Molecular Sciences, 2022 Oxidative stress has been linked with a variety of diseases, being involved in the debut and/or progress of several neurodegenerative disorders. This review intends to summarize some of the findings that correlate the overproduction of reactive oxygen ...
D. Teleanu +8 more
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Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation
Journal of Neuroinflammation, 2021 Background Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain’s immune response, plays an important role in aged associated degeneration of central nervous ...
Andrés Fernández +9 more
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Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities.
Stroke, 2022 Maintaining blood-brain barrier (BBB) integrity is crucial for the homeostasis of the central nervous system. Structurally comprising the BBB, brain endothelial cells interact with pericytes, astrocytes, neurons, microglia, and perivascular macrophages ...
E. Candelario-Jalil +2 more
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Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response
Frontiers in Cellular Neuroscience, 2018 Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization,
Sara Bachiller +6 more
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Journal of Neuroinflammation, 2020 Background Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and
Ferdinand Althammer +6 more
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Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer’s disease
Journal of Neuroinflammation, 2022 Neuroinflammation is instigated by the misfiring of immune cells in the central nervous system (CNS) involving microglia and astrocytes as key cell-types. Neuroinflammation is a consequence of CNS injury, infection, toxicity, or autoimmunity.
Deepali Singh
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Cells, 2022 The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known.
Mario Martínez-Torija +13 more
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