Results 21 to 30 of about 171 (170)

Neuroinflammation in Alzheimer’s Disease [PDF]

open access: yesBiomedicines, 2021
Alzheimer’s disease (AD) is a neurodegenerative disease associated with human aging. Ten percent of individuals over 65 years have AD and its prevalence continues to rise with increasing age. There are currently no effective disease modifying treatments for AD, resulting in increasingly large socioeconomic and personal costs.
Isaac G. Onyango   +4 more
openaire   +4 more sources

Neuroinflammation in Synucleinopathies

open access: yesBrain Pathology, 2016
AbstractThe causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in ...
Somin Lim   +3 more
openaire   +4 more sources

Estrogens, Neuroinflammation, and Neurodegeneration [PDF]

open access: yesEndocrine Reviews, 2016
Inflammatory activation of microglia is a hallmark of several disorders of the central nervous system. In addition to protecting the brain against inflammatory insults, microglia are neuroprotective and play a significant role in maintaining neuronal connectivity, but the prolongation of an inflammatory status may limit the beneficial functions of ...
VILLA, ALESSANDRO MARIA GIOVANNI   +3 more
openaire   +3 more sources

Neuroinflammation in Alzheimer's disease [PDF]

open access: yesThe Lancet Neurology, 2015
Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...
Olga Garaschuk   +41 more
openaire   +11 more sources

Innate Immunity and Neuroinflammation [PDF]

open access: yesMediators of Inflammation, 2013
Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful.
Abhishek Shastri   +2 more
openaire   +5 more sources

Aging‐Driven Blood–Brain Barrier Dysfunction and Its Impact on CNS Cancer Susceptibility: A Comprehensive Narrative Review

open access: yesAging and Cancer, EarlyView.
Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley   +1 more source

Mast Cells and Neuroinflammation [PDF]

open access: yesMedical Science Monitor Basic Research, 2014
It has been determined that there is extensive communication between the immune system and the central nervous system (CNS). Proinflammatory cytokines play a key role in this communication. There is an emerging realization that glia and microglia, in particular, (which are the brain's resident macrophages), are an important source of inflammatory ...
Hongquan Dong, Yanning Qian, Xiang Zhang
openaire   +3 more sources

Neuroinflammation in Friedreich’s Ataxia

open access: yesInternational Journal of Molecular Sciences, 2022
Friedreich’s ataxia (FRDA) is a rare genetic disorder caused by mutations in the gene frataxin, encoding for a mitochondrial protein involved in iron handling and in the biogenesis of iron−sulphur clusters, and leading to progressive nervous system damage.
Savina Apolloni   +2 more
openaire   +3 more sources

Neuroinflammation and Brain Disease

open access: yesBMC Neurology, 2023
AbstractStarting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which
A. Bersano, J. Engele, M.K.E. Schäfer
openaire   +3 more sources

Serotonergic and Dopaminergic Function in Neuropsychiatrically Asymptomatic People With HIV on Antiretroviral Therapy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective People with HIV (PWH) on antiretroviral therapy (ART) still experience neurocognitive dysfunction and accelerated brain volume loss. To assess whether the serotonergic and dopaminergic systems are affected, we used [11C]DASB positron emission tomography (PET) to assess presynaptic serotonergic function and [18F]FDOPA PET to measure ...
Chuen‐Yen Lau   +12 more
wiley   +1 more source

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