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Journal of Neuroinflammation, 2020 An amendment to this paper has been published and can be accessed via the original article.
Ferdinand Althammer +7 more
doaj +1 more source
Acute systemic LPS-exposure impairs perivascular CSF distribution in mice
Journal of Neuroinflammation, 2021 Background The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial ...
Oscar Manouchehrian +4 more
doaj +1 more source
Striatal neuroinflammation promotes parkinsonism in rats [PDF]
, 2008 The specific role of neuroinflammation in the pathogenesis of Parkinson's disease remains to be fully elucidated. By infusing lipopolysaccharide (LPS) into the striatum, we investigated the effect of neuroinflammation on the dopamine nigrostriatal ...
Don Gash +9 more
core +6 more sources
Neuroinflammation in Alzheimer's disease [PDF]
The Lancet Neurology, 2015 Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...
Olga Garaschuk +41 more
openaire +11 more sources
Journal of Neuroinflammation, 2018 Background Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known.
Marija Sajic +5 more
doaj +1 more source
Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology
Journal of Neuroinflammation, 2023 Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper +8 more
doaj +1 more source
Cells, 2021 In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in ...
Alejandro Torrillas de la Cal +7 more
doaj +1 more source
S100B inhibitor pentamidine attenuates reactive gliosis and reduces neuronal loss in a mouse model of Alzheimer's disease [PDF]
, 2015 Among the different signaling molecules released during reactive gliosis occurring in Alzheimer’s disease (AD), the astrocytederived S100B protein plays a key role in neuroinflammation, one of the hallmarks of the disease.
Capoccia, Elena +6 more
core +5 more sources
Neuroinflammation in Bipolar Depression [PDF]
Frontiers in Psychiatry, 2020 Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders. Pathological mechanisms are still vastly unclear, and current treatments with conventional medications are often unsatisfactory in maintaining symptoms control and an adequate quality of life.
Francesco Benedetti +6 more
openaire +4 more sources
Molecular Neurodegeneration, 2022 ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...
Rosalía Fernández-Calle +11 more
doaj +1 more source