Results 31 to 40 of about 212,554 (299)

Correction to: Three-dimensional morphometric analysisreveals time-dependent structural changesin microglia and astrocytes in the centralamygdala and hypothalamicparaventricular nucleus of heart failure rats

Journal of Neuroinflammation, 2020
An amendment to this paper has been published and can be accessed via the original article.
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox, Javier E. Stern   +7 more
doaj   +1 more source

Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Journal of Neuroinflammation, 2021
Background The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial ...
Oscar Manouchehrian, Marta Ramos, Sara Bachiller, Iben Lundgaard, Tomas Deierborg   +4 more
doaj   +1 more source

Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology

Journal of Neuroinflammation, 2023
Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour, Guillaume Dorothée   +8 more
doaj   +1 more source

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, 2021
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
semanticscholar   +1 more source

Mitochondrial damage and “plugging” of transport selectively in myelinated, small-diameter axons are major early events in peripheral neuroinflammation

Journal of Neuroinflammation, 2018
Background Small-diameter, myelinated axons are selectively susceptible to dysfunction in several inflammatory PNS and CNS diseases, resulting in pain and degeneration, but the mechanism is not known.
Marija Sajic, Keila Kazue Ida, Ryan Canning, Norman A. Gregson, Michael R Duchen, Kenneth J Smith   +5 more
doaj   +1 more source

APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

Molecular Neurodegeneration, 2022
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...
Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg   +11 more
doaj   +1 more source

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals

Cells, 2021
In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in ...
Alejandro Torrillas de la Cal, Beatriz Paniagua-Torija, Angel Arevalo-Martin, Christopher Guy Faulkes, Antonio Jesús Jiménez, Isidre Ferrer, Eduardo Molina-Holgado, Daniel Garcia-Ovejero   +7 more
doaj   +1 more source

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

Journal of Neuroinflammation, 2023
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients.
Anbiao Wu, Jiyan Zhang
semanticscholar   +1 more source

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Frontiers in Cellular Neuroscience, 2021
Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage-associated molecular patterns) and/or exogenous pathogens.
F. Takata, Shinsuke Nakagawa, Junichi Matsumoto, S. Dohgu   +3 more
semanticscholar   +1 more source

Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32

Molecules, 2021
Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity.
Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi   +7 more
doaj   +1 more source