Results 31 to 40 of about 308,337 (381)

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Translational Neurodegeneration, 2020
Neuroinflammation is associated with neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Microglia and astrocytes are key regulators of inflammatory responses in the central nervous system. The
H. S. Kwon, S. Koh
semanticscholar   +1 more source

Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Journal of Neuroinflammation, 2023
Background Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the brain tissue of TBI patients and ...
Guihong Shi, Liang Liu, Yiyao Cao, Guang Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Li Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fang Chen, Baolong Wang, Q. Deng, Shu Zhang, Jianning Zhang   +20 more
semanticscholar   +1 more source

Neuroinflammation in Synucleinopathies

Brain Pathology, 2016
AbstractThe causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in ...
Somin, Lim, Yewon, Chun, Jun Sung, Lee, Seung-Jae, Lee   +3 more
openaire   +3 more sources

Correction to: Three-dimensional morphometric analysisreveals time-dependent structural changesin microglia and astrocytes in the centralamygdala and hypothalamicparaventricular nucleus of heart failure rats

Journal of Neuroinflammation, 2020
An amendment to this paper has been published and can be accessed via the original article.
Ferdinand Althammer, Hildebrando Candido Ferreira-Neto, Myurajan Rubaharan, Ranjan K. Roy, Atit A. Patel, Anne Murphy, Daniel N. Cox, Javier E. Stern   +7 more
doaj   +1 more source

Acute systemic LPS-exposure impairs perivascular CSF distribution in mice

Journal of Neuroinflammation, 2021
Background The exchange of cerebrospinal (CSF) and interstitial fluid is believed to be vital for waste clearance in the brain. The sleep-dependent glymphatic system, which is comprised of perivascular flow of CSF and is largely dependent on arterial ...
Oscar Manouchehrian, Marta Ramos, Sara Bachiller, Iben Lundgaard, Tomas Deierborg   +4 more
doaj   +1 more source

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

Journal of Neuroinflammation, 2023
Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability.
Joseph D. Quick, Cristian Silva, J. Wong, Kah-Leong Lim, R. Reynolds, A. Barron, Jialiu Zeng, Chih Hung Lo   +7 more
semanticscholar   +1 more source

An Inflammation-Centric View of Neurological Disease: Beyond the Neuron [PDF]

, 2018
Inflammation is a complex biological response fundamental to how the body deals with injury and infection to eliminate the initial cause of cell injury and effect repair.
Facci, Laura, Giusti, Pietro, Skaper, Stephen D., Zusso, Morena   +3 more
core   +2 more sources

Regulatory T cells decrease C3-positive reactive astrocytes in Alzheimer-like pathology

Journal of Neuroinflammation, 2023
Background Increasing evidence supports a key role for peripheral immune processes in the pathophysiology of Alzheimer’s disease (AD), highlighting an intricate interplay between brain resident glial cells and both innate and adaptive peripheral immune ...
Grégoire Stym-Popper, Karen Matta, Thomas Chaigneau, Roshan Rupra, Alexandros Demetriou, Stéphane Fouquet, Cira Dansokho, Cécile Toly-Ndour, Guillaume Dorothée   +8 more
doaj   +1 more source

The Structure of the Spinal Cord Ependymal Region in Adult Humans Is a Distinctive Trait among Mammals

Cells, 2021
In species that regenerate the injured spinal cord, the ependymal region is a source of new cells and a prominent coordinator of regeneration. In mammals, cells at the ependymal region proliferate in normal conditions and react after injury, but in ...
Alejandro Torrillas de la Cal, Beatriz Paniagua-Torija, Angel Arevalo-Martin, Christopher Guy Faulkes, Antonio Jesús Jiménez, Isidre Ferrer, Eduardo Molina-Holgado, Daniel Garcia-Ovejero   +7 more
doaj   +1 more source

Imaging of neuroinflammation [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2011
For those of us interested in molecular imaging of the majorneurodegenerative disorders, the last decade has witnessed amarked advancement. From basic research to clinical studies,the field has evolved using multidisciplinary techniques andskills, leading to results of significant clinical interest.Reasoning on the role of inflammation in ...
openaire   +2 more sources