Results 31 to 40 of about 163,150 (371)

Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation

open access: yesJournal of Neuroinflammation, 2021
Background Aging and age-related diseases are strong risk factors for the development of neurodegenerative diseases. Neuroinflammation (NIF), as the brain’s immune response, plays an important role in aged associated degeneration of central nervous ...
Andrés Fernández   +9 more
doaj   +1 more source

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

open access: yesJournal of Neuroinflammation, 2023
As one of most common and severe mental disorders, major depressive disorder (MDD) significantly increases the risks of premature death and other medical conditions for patients.
Anbiao Wu, Jiyan Zhang
semanticscholar   +1 more source

Three-dimensional morphometric analysis reveals time-dependent structural changes in microglia and astrocytes in the central amygdala and hypothalamic paraventricular nucleus of heart failure rats

open access: yesJournal of Neuroinflammation, 2020
Background Cardiovascular diseases, including heart failure, are the most common cause of death globally. Recent studies support a high degree of comorbidity between heart failure and cognitive and mood disorders resulting in memory loss, depression, and
Ferdinand Althammer   +6 more
doaj   +1 more source

NLRP3 monomer Functional Dynamics: from the Effects of Allosteric Binding to Implications for Drug Design [PDF]

open access: yesInternational Journal of Biological Macromolecules 246 (2023) 125609, 2023
The protein NLRP3 and its complexes are associated with an array of inflammatory pathologies, among which neurodegenerative, autoimmune, and metabolic diseases. Targeting the NLRP3 inflammasome represents a promising strategy for easing the symptoms of pathologic neuroinflammation.
arxiv   +1 more source

Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease

open access: yesJournal of Neuroinflammation, 2023
Alzheimer’s disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile plaque (SP) formation.
Minghui Wang   +4 more
semanticscholar   +1 more source

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

open access: yesFrontiers in Cellular Neuroscience, 2018
Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization,
Sara Bachiller   +6 more
doaj   +1 more source

Catalytically Potent and Selective Clusterzymes for Modulation of Neuroinflammation Through Single-Atom Substitutions [PDF]

open access: yesNature Communications,2020, 2020
Emerging artificial enzymes with reprogrammed and augmented catalytic activity and substrate selectivity have long been pursued with sustained efforts. The majority of current candidates rely on noble metals or transition metal oxides with rather poor catalytic activity compared with natural molecules.
arxiv   +1 more source

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

open access: yesJournal of Neuroinflammation, 2021
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
semanticscholar   +1 more source

Post-COVID Complications after Pressure Ulcer Surgery in Patients with Spinal Cord Injury Associate with Creatine Kinase Upregulation in Adipose Tissue

open access: yesCells, 2022
The risk of complications following surgical procedures is significantly increased in patients with SARS-CoV-2 infection. However, the mechanisms underlying these correlations are not fully known.
Mario Martínez-Torija   +13 more
doaj   +1 more source

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2021
Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou   +8 more
semanticscholar   +1 more source

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