Results 31 to 40 of about 252,991 (337)
Neuroinflammation in Alzheimer's disease [PDF]
The Lancet Neurology, 2015 Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia, and trigger an innate immune response characterised by release ...Olga Garaschuk, Stéphane Hunot, Bente Finsen, Gabor C. Petzold, David J. Brooks, Bertrand Joseph, John C.S. Breitner, Karl Herrup, Javier Vitorica, Frederic Brosseron, Koji Yamanaka, Douglas T. Golenbock, Monica J. Carson, Andreas H. Jacobs, Richard M. Ransohoff, Erik Boddeke, Tony Wyss-Coray, Tony Wyss-Coray, Eicke Latz, Eicke Latz, Dave Morgan, Joseph El Khoury, Charles A. Dinarello, Greg M. Cole, Terrence Town, Mari L. Shinohara, Clive Holmes, Clive Holmes, V. Hugh Perry, Nicolas G. Bazan, Jari Koistinaho, Gary E. Landreth, Michael T. Heneka, Nikolaus Deigendesch, Alexei Verkhratsky, Alexei Verkhratsky, Alexei Verkhratsky, Sally A. Frautschy, Annett Halle, Douglas L. Feinstein, Markus P. Kummer, Guy C. Brown +41 moreopenaire +11 more sourcesAPOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases
Molecular Neurodegeneration, 2022 ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of the most influential risk factors for the development of late-onset Alzheimer's ...Rosalía Fernández-Calle, Sabine C. Konings, Javier Frontiñán-Rubio, Juan García-Revilla, Lluís Camprubí-Ferrer, Martina Svensson, Isak Martinson, Antonio Boza-Serrano, José Luís Venero, Henrietta M. Nielsen, Gunnar K. Gouras, Tomas Deierborg +11 moredoaj +1 more sourceNeuroinflammation in Synucleinopathies
Brain Pathology, 2016 AbstractThe causes of most neurodegenerative diseases are attributed to multiple genetic and environmental factors interacting with one another. Above all, inflammation in the nervous system has been implicated in many neurodegenerative diseases. Still, the roles of neuroinflammation in disease mechanisms and the triggers of inflammatory responses in ...Somin Lim, Seung-Jae Lee, Yewon Chun, Jun Sung Lee +3 moreopenaire +4 more sourcesImidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32
Molecules, 2021 Imidazo[1,2-b]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity.Rakesh Kumar Sharma, Manisha Singh, Khagendra Ghimeray, Pinky Juneja, Gagan Dev, Sridhar Pulavarthi, Sabbasani Rajasekhara Reddy, Ravi Shankar Akundi +7 moredoaj +1 more sourceNeuroinflammation in Alzheimer’s Disease [PDF]
Biomedicines, 2021 Alzheimer’s disease (AD) is a neurodegenerative disease associated with human aging. Ten percent of individuals over 65 years have AD and its prevalence continues to rise with increasing age. There are currently no effective disease modifying treatments for AD, resulting in increasingly large socioeconomic and personal costs.Isaac G. Onyango, Gretsen V. Jauregui, Mária Čarná, James P. Bennett, Gorazd B. Stokin +4 moreopenaire +4 more sourcesTargeting neuroinflammation in Alzheimer’s disease [PDF]
, 2016 Almost 47 million people suffer from dementia worldwide, with an estimated
new case diagnosed every 3.2 seconds. Alzheimer’s disease (AD) accounts for approximately
60%–80% of all dementia cases. Given this evidence, it is clear dementia represents one Bronzuoli, MARIA ROSANNA, Iacomino, Aniello, Scuderi, Caterina, Steardo, Luca +3 morecore +1 more sourceEarly-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner
Journal of Neuroinflammation, 2022 Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing ...S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg +12 moredoaj +1 more sourceNeuroinflammation, Mast Cells, and Glia: Dangerous Liaisons [PDF]
, 2017 The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders.Alhouayek M, Amor S, Amor S, Appel SH, Bankston AN, Biber K, Biran V, Borsook D, Brenner T, Brooks TA, Buchanan MM, Bulanova E, Burnstock G, Calcia MA, Castellheim A, Chan-Ling T, Chen YJ, Choudhuri K, Christophi GP, Christy AL, Compston A, Conti P, Corrigan F, Cristino L, Cunningham C, Dirckx M, Donath MY, Done JD, D’Agostino G, Eckenhoff RG, Eggen BJ, Ellis A, Engler H, Ertürk A, Eskander MA, Esposito P, Fonken LK, Forsythe P, Freeman LC, Fullerton JN, Gao YJ, Gaudenzio N, Geppetti P, Grace PM, Grakoui A, Gregory GD, Griffin RS, Guerreiro R, Gunin AG, Hagiyama M, Hains LE, Hanisch UK, Harcha PA, Harvey GK, Hayashi R, Heneka MT, Hickman SE, Hsieh CL, Hu W, Héron A, Iadecola C, Ito A, Jay GW, Jensen TS, Ji RR, Jin Y, Jin Y, Juremalm M, Kajihara Y, Kalesnikoff J, Kalichman MW, Kamm CP, Kerstman E, Kobayashi K, Kolbinger F, Koshinaga M, Kwon C, Lange C, Lapilover EG, Laura Facci, Le Thuc O, Leon A, Levy D, Li M, Li X, Liew FY, Lozada A, Lull ME, Luongo L, Manocha GD, Marchi N, Martini R, Maslinska D, Mate I, Matsuda H, Mattila OS, McGeer PL, Medeiros R, Medic N, Medic N, Michaloudi H, Michaud M, Millan MJ, Miller G, Milligan ED, Monks CR, Morena Zusso, Myers RR, Nakae S, Nakajima A, Nathan C, Nave KA, Nelissen S, Nguyen M, Norden DM, Noriega DB, Old EA, Orr AG, Osipchuk Y, Osterberg A, Park CK, Parvathenani LK, Patti GJ, Peferoen L, Peferoen LA, Pekny M, Pelisch N, Perry VH, Perry VH, Pietro Giusti, Prinz M, Prussin C, Punzo D, Ramlackhansingh AF, Ransohoff RM, Rapp JH, Rawji KS, Riedel B, Rivat C, Rosa AC, Sakamoto A, Sastre M, Sayed BA, Silver R, Silverman AJ, Sivanandam TM, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skaper SD, Skuljec J, Smith BH, Smith JA, Sospedra M, Stephen D. Skaper, Streit WJ, Suurmond J, Terrando N, Thacker MA, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Theoharides TC, Ulmann L, van Hecke O, Varma R, von Büdingen HC, Vyas H, Wang M, Wang Y, Wardlaw AJ, Watkins LR, Wohleb ES, Xie F, Young KM, Yuan H, Zarpelon AC, Zeis T, Zhang H, Zhang S, Zhang ZG, Zuo Y +183 morecore +1 more sourceNeuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure. [PDF]
, 2016 BackgroundIntra-amniotic Candida albicans (C. Albicans) infection is associated with preterm birth and high morbidity and mortality rates. Survivors are prone to adverse neurodevelopmental outcomes.AJ Wolfberg, Allan H. Jobe, AM Alsaad, AW Gavilanes, AW Gavilanes, B Fleiss, BE Deverman, Benno Küsters, BH Yoon, Boris W. Kramer, C Perego, C Perego, Daan R. M. G. Ophelders, DB DiGiulio, DH Navarathna, E Kuypers, E Kuypers, E Rocha, G Maneenil, HJ Bonestroo, IC Hoogland, JJ Collins, JJ Volpe, JM Dean, John P. Newnham, JR Buser, KN Segovia, LC Schmued, LM Bean, Luc J. Zimmermann, M Atzori, M Gantert, Martin Lammens, Matthew S. Payne, Matthew W. Kemp, MJ Keogh, MS Lionakis, MS Payne, MS Payne, MW Kemp, NY Tsai, O Dammann, O Dammann, R Filipovic, R Galinsky, R Gomez, RL Goldenberg, RL Goldenberg, Ruth Gussenhoven, S Biesmans, S Malaeb, S Rees, S Rivest, SA Back, SA Back, SS Billiards, Suhas G. Kallapur, T Meizoso, TG Wolfs, Tim G. A. M. Wolfs, V Agrawal, V Chau, VV Moudgal, YW Wu +63 morecore +10 more sources
