Results 41 to 50 of about 135,205 (333)

Imaging of neuroinflammation [PDF]

European Journal of Nuclear Medicine and Molecular Imaging, 2011
For those of us interested in molecular imaging of the majorneurodegenerative disorders, the last decade has witnessed amarked advancement. From basic research to clinical studies,the field has evolved using multidisciplinary techniques andskills, leading to results of significant clinical interest.Reasoning on the role of inflammation in ...
openaire   +3 more sources

Fully automated segmentation of the cervical cord from T1-weighted MRI using PropSeg: Application to multiple sclerosis

NeuroImage: Clinical, 2016
Spinal cord (SC) atrophy, i.e. a reduction in the SC cross-sectional area (CSA) over time, can be measured by means of image segmentation using magnetic resonance imaging (MRI).
Marios C. Yiannakas, Ahmed M. Mustafa, Benjamin De Leener, Hugh Kearney, Carmen Tur, Daniel R. Altmann, Floriana De Angelis, Domenico Plantone, Olga Ciccarelli, David H. Miller, Julien Cohen-Adad, Claudia A.M. Gandini Wheeler-Kingshott   +11 more
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Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury

Scientific Reports, 2023
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates
Daniela Alí-Ruiz, Nathalia Vitureira, Hugo Peluffo   +2 more
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Experimental autoimmune encephalomyelitis from a tissue energy perspective [version 1; referees: 2 approved]

F1000Research, 2017
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the ...
Roshni A Desai, Kenneth J Smith
doaj   +1 more source

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
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Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner

Brain, Behavior, & Immunity - Health, 2020
Early life adversities during childhood (such as maltreatment, abuse, neglect, or parental deprivation) may increase the vulnerability to cognitive disturbances and emotional disorders in both, adolescence and adulthood.
S. Bachiller, A. Paulus, S. Vázquez-Reyes, I. García-Domínguez, T. Deierborg   +4 more
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Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
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Sarcoidosis and neuromyelitis optica in a patient with optic neuritis – a case report

Annals of Clinical and Translational Neurology, 2021
We present a case of atypical recurrent optic neuritis. A man in his 50s presented with right optic neuritis and profound visual loss, associated with elevated inflammatory markers. Lymph‐node biopsy was consistent with sarcoidosis.
Michael A. Foster, Sara Collorone, Jacqueline Palace, James Acheson, Ahmed T. Toosy   +4 more
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Innate Immunity and Neuroinflammation [PDF]

Mediators of Inflammation, 2013
Inflammation of central nervous system (CNS) is usually associated with trauma and infection. Neuroinflammation occurs in close relation to trauma, infection, and neurodegenerative diseases. Low-level neuroinflammation is considered to have beneficial effects whereas chronic neuroinflammation can be harmful.
Abhishek Shastri, Domenico Marco Bonifati, Uday Kishore   +2 more
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Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure

Communications Biology
Activation of microglia, the resident immune cells of the central nervous system, leading to the subsequent release of pro-inflammatory cytokines, has been linked to cardiac remodeling, autonomic disbalance, and cognitive deficits in heart failure (HF ...
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Yuval Podpecan, Jemima Helen, Shaina McGrath, Elba Campos Lira, Javier E. Stern   +7 more
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