Results 51 to 60 of about 212,554 (299)

NLRP3 inflammasome in neuroinflammation and central nervous system diseases

Cellular & Molecular Immunology
Neuroinflammation plays an important role in the pathogenesis of various central nervous system (CNS) diseases. The NLRP3 inflammasome is an important intracellular multiprotein complex composed of the innate immune receptor NLRP3, the adaptor protein ...
Wenjing Xu, Yi Huang, Rongbin Zhou
semanticscholar   +1 more source

Lipopolysaccharide-Induced Model of Neuroinflammation: Mechanisms of Action, Research Application and Future Directions for Its Use

Molecules, 2022
Despite advances in antimicrobial and anti-inflammatory therapies, inflammation and its consequences still remain a significant problem in medicine. Acute inflammatory responses are responsible for directly life-threating conditions such as septic shock;
Anna Skrzypczak-Wiercioch, K. Sałat
semanticscholar   +1 more source

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
doaj   +1 more source

Neuroinflammation: friend and foe for ischemic stroke

Journal of Neuroinflammation, 2019
Stroke, the third leading cause of death and disability worldwide, is undergoing a change in perspective with the emergence of new ideas on neurodegeneration.
Richard L. Jayaraj, S. Azimullah, R. Beiram, F. Jalal, G. Rosenberg   +4 more
semanticscholar   +1 more source

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +1 more source

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Frontiers in Aging Neuroscience
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory
Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue   +3 more
semanticscholar   +1 more source

Inhibition of neutrophil extracellular trap formation ameliorates neuroinflammation and neuronal apoptosis via STING-dependent IRE1α/ASK1/JNK signaling pathway in mice with traumatic brain injury

Journal of Neuroinflammation, 2023
Background Neuroinflammation is one of the most important pathogeneses in secondary brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming neutrophils were found throughout the brain tissue of TBI patients and ...
Guihong Shi, Liang Liu, Yiyao Cao, Guang Ma, Yanlin Zhu, Jianye Xu, Xu Zhang, Tuo Li, Li Mi, Haoran Jia, Yanfeng Zhang, Xilei Liu, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fang Chen, Baolong Wang, Q. Deng, Shu Zhang, Jianning Zhang   +20 more
semanticscholar   +1 more source

The Impact of Tilburg Frailty on Poststroke Fatigue in First‐Ever Stroke Patients: A Cross‐Sectional Study With Unified Measurement Tools and Improved Statistics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen, Xiao‐Xue Wang, Shao‐Rui Bao, Sui‐Li Lin, Mei‐Chun Shu, Xi‐Xi Ye, Wen‐Jie Cong   +6 more
wiley   +1 more source

Angiotensin-II drives changes in microglia–vascular interactions in rats with heart failure

Communications Biology
Activation of microglia, the resident immune cells of the central nervous system, leading to the subsequent release of pro-inflammatory cytokines, has been linked to cardiac remodeling, autonomic disbalance, and cognitive deficits in heart failure (HF ...
Ferdinand Althammer, Ranjan K. Roy, Matthew K. Kirchner, Yuval Podpecan, Jemima Helen, Shaina McGrath, Elba Campos Lira, Javier E. Stern   +7 more
doaj   +1 more source

Unraveling the Complex Interplay Between Neuroinflammation and Depression: A Comprehensive Review

International Journal of Molecular Sciences
The relationship between neuroinflammation and depression is a complex area of research that has garnered significant attention in recent years. Neuroinflammation, characterized by the activation of glial cells and the release of pro-inflammatory ...
Andreea Sălcudean, R. Popovici, Dana Emanuela Pitic, Diana Sârbu, A. Boroghina, Mohammad Jomaa, Matin Asad Salehi, Alsayed Ahmad Mhd Kher, Maria-Melania Lica, C. Bodo, V. Enătescu   +10 more
semanticscholar   +1 more source