Results 51 to 60 of about 308,337 (381)

Parkinson's disease: autoimmunity and neuroinflammation [PDF]

, 2016
Parkinson's disease is a neurodegenerative disease that causes the death of dopaminergic neurons in the substantia nigra. The resulting dopamine deficiency in the basal ganglia leads to a movement disorder that is characterized by classical parkinsonian ...
CINIGLIO APPIANI, MARIO, CONTE, MICHELA, DE VINCENTIIS, Marco, DE VIRGILIO, ARMANDO, FABBRINI, Giovanni, GALLO, Andrea, GRECO, Antonio, INGHILLERI, Maurizio, RIZZO, MARIA IDA, ROSATO, CHIARA   +9 more
core   +1 more source

Exercise suppresses neuroinflammation for alleviating Alzheimer’s disease

Journal of Neuroinflammation, 2023
Alzheimer’s disease (AD) is a chronic neurodegenerative disease, with the characteristics of neurofibrillary tangle (NFT) and senile plaque (SP) formation.
Minghui Wang, Hu Zhang, Jiling Liang, Jielun Huang, Ning Chen   +4 more
semanticscholar   +1 more source

NEUROINFLAMMATION [PDF]

International Journal of Neuroscience Research, 2021
Inflammation is a complex process, mediated by cellular and molecular mechanisms caused by a response to a tissue damage from an aggressive agent, whether if biological, chemical or physical origin. This process occurs, ultimately, with the purpose of promoting defense, repair and tissue regeneration.
openaire   +1 more source

Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats. [PDF]

, 2016
BackgroundHyperhomocysteinemia (HHcy) is associated with inflammation and a rise in the expression of matrix metalloproteinase-9 (MMP-9) in the vascular wall.
Hashimoto, Tomoki, Kanematsu, Yasuhisa, Kitazato, Keiko T, Korai, Masaaki, Matsushita, Nobuhisa, Miyamoto, Takeshi, Nagahiro, Shinji, Satomi, Junichiro, Shimada, Kenji, Tada, Yoshiteru   +9 more
core   +2 more sources

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner

Journal of Neuroinflammation, 2022
Background The risk of developing Alzheimer’s disease (AD) is modulated by genetic and environmental factors. Early-life stress (ELS) exposure during critical periods of brain development can impact later brain function and health, including increasing ...
S. Bachiller, I. Hidalgo, M. G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, O. Klementieva, J. Y. Li, C. J. Pronk, G. K. Gouras, T. Deierborg   +12 more
doaj   +1 more source

The link between neuroinflammation and the neurovascular unit in synucleinopathies

Science Advances, 2023
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier ...
Qing Wang, Jialing Zheng, Sven Pettersson, R. Reynolds, E. Tan   +4 more
semanticscholar   +1 more source

Microglial CD300f immune receptor contributes to the maintenance of neuron viability in vitro and after a penetrating brain injury

Scientific Reports, 2023
Emerging evidences suggest that immune receptors participate in diverse microglial and macrophage functions by regulating their immunometabolism, inflammatory phenotype and phagocytosis. CD300f, a TREM2-like lipid sensing immune receptor, that integrates
Daniela Alí-Ruiz, Nathalia Vitureira, Hugo Peluffo   +2 more
doaj   +1 more source

Structural and Functional Alterations in Visual Pathway After Optic Neuritis in MOG Antibody Disease: A Comparative Study With AQP4 Seropositive NMOSD

Frontiers in Neurology, 2021
Background: Optic neuritis (ON) is an important clinical manifestation of neuromyelitis optic spectrum disease (NMOSD). Myelin oligodendrocyte glycoprotein (MOG) antibody-related and aquaporin 4 (AQP4) antibody-related ON show different disease patterns.
Chenyang Gao, Zhizheng Zhuo, Yunyun Duan, Yajun Yao, Lei Su, Xinghu Zhang, Tian Song   +6 more
doaj   +1 more source

Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?

Frontiers in Aging Neuroscience, 2022
As inflammation in the brain contributes to several neurological and psychiatric diseases, the cause of neuroinflammation is being widely studied.
Yuanjie Sun, Y. Koyama, Shoichi Shimada
semanticscholar   +1 more source