Results 71 to 80 of about 308,337 (381)

Experimental autoimmune encephalomyelitis from a tissue energy perspective [version 1; referees: 2 approved]

F1000Research, 2017
Increasing evidence suggests a key role for tissue energy failure in the pathophysiology of multiple sclerosis (MS). Studies in experimental autoimmune encephalomyelitis (EAE), a commonly used model of MS, have been instrumental in illuminating the ...
Roshni A Desai, Kenneth J Smith
doaj   +1 more source

The semantics of microglia activation: neuroinflammation, homeostasis, and stress

Journal of Neuroinflammation, 2021
Microglia are emerging as critical regulators of neuronal function and behavior in nearly every area of neuroscience. Initial reports focused on classical immune functions of microglia in pathological contexts, however, immunological concepts from these ...
S. Woodburn, J. Bollinger, E. Wohleb
semanticscholar   +1 more source

Forced treadmill exercise can induce stress and increase neuronal damage in a mouse model of global cerebral ischemia

Neurobiology of Stress, 2016
Physical exercise is known to be a beneficial factor by increasing the cellular stress tolerance. In ischemic stroke, physical exercise is suggested to both limit the brain injury and facilitate behavioral recovery.
Martina Svensson, Philip Rosvall, Antonio Boza-Serrano, Emelie Andersson, Jan Lexell, Tomas Deierborg   +5 more
doaj   +1 more source

Blood-Brain Barrier Dysfunction Amplifies the Development of Neuroinflammation: Understanding of Cellular Events in Brain Microvascular Endothelial Cells for Prevention and Treatment of BBB Dysfunction

Frontiers in Cellular Neuroscience, 2021
Neuroinflammation is involved in the onset or progression of various neurodegenerative diseases. Initiation of neuroinflammation is triggered by endogenous substances (damage-associated molecular patterns) and/or exogenous pathogens.
F. Takata, Shinsuke Nakagawa, Junichi Matsumoto, S. Dohgu   +3 more
semanticscholar   +1 more source

Fc-Galactosylation of Human Immunoglobulin Gamma Isotypes Improves C1q Binding and Enhances Complement-Dependent Cytotoxicity

Frontiers in Immunology, 2017
Binding of the complement component C1q to the CH2 domain of antigen-bound immunoglobulin gamma (IgG) activates the classical complement pathway and depends on its close proximity to Fc fragments of neighboring antibodies. IgG subclasses contain a highly
Benjamin Peschke, Christian W. Keller, Patrick Weber, Isaak Quast, Isaak Quast, Jan D. Lünemann, Jan D. Lünemann   +6 more
doaj   +1 more source

The role of neuroinflammation in neurodegenerative diseases: current understanding and future therapeutic targets

Frontiers in Aging Neuroscience
Neuroinflammation refers to a highly complicated reaction of the central nervous system (CNS) to certain stimuli such as trauma, infection, and neurodegenerative diseases. This is a cellular immune response whereby glial cells are activated, inflammatory
Alhamdu Adamu, Shuo Li, Fankai Gao, Guofang Xue   +3 more
semanticscholar   +1 more source

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou, Yong Wei, Sofie Lautrup, Beimeng Yang, Yue Wang, Stephanie Cordonnier, M. Mattson, D. Croteau, V. Bohr   +8 more
semanticscholar   +1 more source

Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure. [PDF]

, 2016
BackgroundIntra-amniotic Candida albicans (C. Albicans) infection is associated with preterm birth and high morbidity and mortality rates. Survivors are prone to adverse neurodevelopmental outcomes.
AJ Wolfberg, Allan H. Jobe, AM Alsaad, AW Gavilanes, AW Gavilanes, B Fleiss, BE Deverman, Benno Küsters, BH Yoon, Boris W. Kramer, C Perego, C Perego, Daan R. M. G. Ophelders, DB DiGiulio, DH Navarathna, E Kuypers, E Kuypers, E Rocha, G Maneenil, HJ Bonestroo, IC Hoogland, JJ Collins, JJ Volpe, JM Dean, John P. Newnham, JR Buser, KN Segovia, LC Schmued, LM Bean, Luc J. Zimmermann, M Atzori, M Gantert, Martin Lammens, Matthew S. Payne, Matthew W. Kemp, MJ Keogh, MS Lionakis, MS Payne, MS Payne, MW Kemp, NY Tsai, O Dammann, O Dammann, R Filipovic, R Galinsky, R Gomez, RL Goldenberg, RL Goldenberg, Ruth Gussenhoven, S Biesmans, S Malaeb, S Rees, S Rivest, SA Back, SA Back, SS Billiards, Suhas G. Kallapur, T Meizoso, TG Wolfs, Tim G. A. M. Wolfs, V Agrawal, V Chau, VV Moudgal, YW Wu   +63 more
core   +10 more sources

Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies

International Journal of Molecular Sciences, 2021
Its increasing incidence has led stroke to be the second leading cause of death worldwide. Despite significant advances in recanalization strategies, patients are still at risk for ischemia/reperfusion injuries in this pathophysiology, in which ...
Anamaria Jurcău, A. Simion
semanticscholar   +1 more source

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]

, 2015
BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott, Mante, Michael, Masliah, Eliezer, Rockenstein, Edward, Valera, Elvira   +4 more
core   +2 more sources