Results 81 to 90 of about 252,991 (337)

Pathophysiologisch-serologische, bildgebende und klinische Charakteristika der Neuromyelitis Optica [PDF]

, 2019
Hintergrund: Neuromyelitis optica-Spektrum-Erkrankungen (NMOSD) stellen eine Gruppe neuroinflammatorischer Erkrankungen dar, die mit dem klinischen Auftreten von Myelitiden und/oder Optikusneuritiden (ON) einhergeht.
Schumacher, Sophie
core   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, EarlyView.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

TRAP1 in Oxidative Stress and Neurodegeneration

Antioxidants, 2021
Tumor necrosis factor receptor-associated protein 1 (TRAP1), also known as heat shock protein 75 (HSP75), is a member of the heat shock protein 90 (HSP90) chaperone family that resides mainly in the mitochondria.
Inês Ramos Rego, Beatriz Santos Cruz, António Francisco Ambrósio, Celso Henrique Alves   +3 more
doaj   +1 more source

Neuroinflammation and white matter alterations in obesity assessed by Diffusion Basis Spectrum Imaging [PDF]

, 2019
Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in ...
Ances, Beau M, Eisenstein, Sarah A, Hershey, Tamara, Murphy, Tatianna, Neyman, Olga, Rutlin, Jerrel, Samara, Amjad, Shimony, Joshua S, Song, Sheng-Kwei, Sreevalsan, Nitya, Strain, Jeremy, Sun, Peng   +11 more
core   +1 more source

Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND:Retinal optical coherence tomography (OCT) is a clinical and research tool in multiple sclerosis, where it has shown significant retinal nerve fiber (RNFL) and ganglion cell (RGC) layer thinning, while postmortem studies have reported RGC loss.
Aktas, Orhan, Albrecht, Philipp, Balk, Lisanne J, Cordano, Christian, Cruz-Herranz, Andrés, Dietrich, Michael, Fischer, Dietmar, Green, Ari J, Hallenberger, Angelika, Hartung, Hans-Peter, Hecker, Christina, Hilla, Alexander M, Ingwersen, Jens, Issberner, Andrea, Lehmann-Horn, Klaus, Levin, Marc H, von Gall, Charlotte, Yiu, Hao H, Zamvil, Scott S   +18 more
core   +1 more source

Neuroinflammation and Brain Disease

BMC Neurology, 2023
AbstractStarting from the perspective of an immune-privileged site, our knowledge of the inflammatory processes within the central nervous system has increased rapidly over the last 30 years, leading to a rather puzzling picture today. Of particular interest is the emergence of disease- and injury-specific inflammatory responses within the brain, which
A. Bersano, J. Engele, M.K.E. Schäfer
openaire   +3 more sources

Pre‐Diagnostic Features of Multiple Sclerosis in a Diverse UK Cohort: A Nested Case–Control Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Many patients with Multiple Sclerosis (MS) experience nonspecific symptoms prior to diagnosis. This period—the 'MS prodrome'—has been described in socio‐economically homogeneous cohorts to date. It remains unclear to what extent events prior to an MS diagnosis differ according to social determinants of health. Methods We conducted a
Pooja Tank, Benjamin M. Jacobs, Jonathan Bestwick, Ruth Dobson   +3 more
wiley   +1 more source

Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms

Neurobiology of Disease, 2002
We have studied the neurotoxicity of amyloid-beta (Aβ) after a single unilateral intravitreal injection. Within the retina apoptotic cells were seen throughout the photoreceptor layer and the inner nuclear layer but not in the ganglion cell layer at 48 h
Desmond T. Walsh, Rosa M. Montero, Laura G. Bresciani, Angela Y.T. Jen, Pascale D. Leclercq, Debbie Saunders, Ahmed N. EL-Amir, Lukemann Gbadamoshi, Stephen M. Gentleman, Ling-Sun Jen   +9 more
doaj   +1 more source

Neonatal cytokines and chemokines and risk of Autism Spectrum Disorder: the Early Markers for Autism (EMA) study: a case-control study. [PDF]

, 2014
BackgroundBiologic markers of infection and inflammation have been associated with Autism Spectrum Disorders (ASD) but prior studies have largely relied on specimens taken after clinical diagnosis.
Ashwood, Paul, Croen, Lisa A, Delorenze, Gerald N, Grether, Judith K, Hansen, Robin L, Kharrazi, Marty, Van de Water, Judy, Yoshida, Cathleen, Zerbo, Ousseny   +8 more
core   +3 more sources

Plasma Glial Fibrillary Acidic Protein Correlates With Brain Metal Burden in Wilson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuroinflammation driven by extracellular copper contributes to neuronal damage in Wilson's disease (WD). This study investigated the relationship between brain metal burden and peripheral neuroinflammation markers in WD. Methods We conducted a cross‐sectional study involving 89 participants, including patients with WD (n = 63 ...
Sung‐Pin Fan, Ya‐Fang Chen, Cheng‐Hsuan Li, Yih‐Chih Kuo, Ni‐Chung Lee, Yin‐Hsiu Chien, Wuh‐Liang Hwu, Tai‐Chung Tseng, Tung‐Hung Su, Chien‐Ting Hsu, Huey‐Ling Chen, Chin‐Hsien Lin, Yen‐Hsuan Ni   +12 more
wiley   +1 more source