Results 101 to 110 of about 4,528 (158)

Neurokinin A as a Potent Bronchoconstrictor

American Review of Respiratory Disease, 1987
Abstract Neurokinin A (NKA) and B (NKB) were more potent bronchoconstrictive agents than substance P (SP) in guinea pig tracheal strips. The content of NKA in guinea pig lung homogenate was 2.26 α 1.09 pmol/g wet lung, which was approximately half that of SP (4.46 α 1.33 pmol/g wet lung); NKB was not detected in the guinea pig lung ...
Y, Uchida, A, Nomura, M, Ohtsuka, S, Hasegawa, K, Goto, S, Kimura, Y, Sugita, Y, Uchiyama   +7 more
openaire   +2 more sources

Pharmacology of neurokinin receptors

Biopolymers, 1991
AbstractThe neurokinins are a group of naturally occurring peptides with the common C‐terminal sequence Phe‐X‐Gly‐Leu‐Met · NH2. They include substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). SP and NKA are coded on the same gene, the PPT‐A, while NKB is coded on a separate gene, the PPT‐B.
D, Regoli, F, Nantel
openaire   +2 more sources

Site-specific effects of intracerebral injections of three neurokinins (neurokinin A, neurokinin K, and neurokinin γ) on the expression of male rat sexual behavior

Physiology & Behavior, 1993
Accumulating evidence indicates that neurokinins play a role in the neural regulation of male rat copulatory behavior. We have previously reported that injections of the neurokinin substance P into the medial preoptic nucleus facilitated male rat copulatory behavior.
W A, Dornan, K L, Vink, P, Malen, K, Short, W, Struthers, C, Barrett   +5 more
openaire   +2 more sources

Functional development of neurokinin peptides substance P and neurokinin A in nociception

NeuroReport, 2003
It is unclear how neonates respond to noxious stimuli. This study examined the role of neurokinin peptides in 3- and 21-day-old rat pups using the preprotachykinin-A (PPTA) knockout mouse, lacking neurokinin A and substance P. We assessed pain behaviors of these mice before the neurokinin system is putatively active, 3 days after birth, and after this ...
Tamara E, King, Gordon A, Barr
openaire   +2 more sources

Developmental expression of neurokinin A and functional neurokinin-2 receptors in lung

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2001
Peribronchial smooth muscle constriction causes airway stretch, an important mechanical force in developing lung. Little is known about factors influencing these spontaneously active muscle elements. We measured contractile activity of neurokinin (NK) receptors on fetal intrapulmonary smooth muscle by tracheal perfusion assay ( n = 11).
K J, Haley, M E, Sunday, R, Osathanondh, J, Du, C, Vathanaprida, V V, Karpitsky, J E, Krause, C M, Lilly   +7 more
openaire   +2 more sources

The effects of neurokinin A, neurokinin B, and eledoisin on substance P analysis

Journal of Clinical Monitoring, 1991
Commercial sources for neuropeptide radioimmunoassays have made this sensitive tool available to clinical investigators for monitoring the potential involvement of neuropeptides in pain modulation. We measured substance P-like immunoreactivity in the plasma, saliva, and pericardial fluid of subjects with and without pain (chronic and acute) to ...
R J, Naukam, W C, Parris, J R, Kambam, J B, Kruskal   +3 more
openaire   +2 more sources

Neurokinin-1 and neurokinin-3 receptors in primate substantia nigra

Neuroscience Research, 2007
Striatonigral axons co-release GABA and substance P (SP) at their target sites, but little is known about the action of SP at nigral level. Therefore, we studied immunohistochemically the cellular and subcellular localization of SP and its high affinity receptors neurokinin-1 (NK-1R) and neurokinin-3 (NK-3R) at nigral level in squirrel monkeys ...
Martin, Lévesque, Marie-Josée, Wallman, Remy, Parent, Attila, Sík, André, Parent   +4 more
openaire   +2 more sources

Relative bronchoconstrictor activity of neurokinin A and neurokinin A fragments in guinea pigs

Journal of Applied Physiology, 1991
We examined the effect of rapid intravenous infusion of neurokinin A (NKA) and selected COOH-terminal NKA fragments on pulmonary conductance (GL) and dynamic compliance in anesthetized mechanically ventilated guinea pigs. The rank order of the dose of peptide required to reduce GL by 50% (ED50GL) was NKA = NKA2–10 = NKA3–10 = NKA4–10 less than NKA5–10
S A, Shore, J M, Drazen
openaire   +2 more sources

Structure-Activity Study of Neurokinins: Antagonists for the Neurokinin-2 Receptor

Pharmacology, 2008
A series of 21 peptides were synthesized and tested in a variety of isolated organs in order to determine their potential as neurokinin-2 (NK-2) antagonists. The peptides have been tested in the three monoreceptor systems, the dog carotid artery (NK-1), the rabbit pulmonary artery (NK-2) and the rat portal vein (NK-3) as well as on other preparations ...
S. Dion, N. Rouissi, F. Nantel, D. Jukic, N.-E. Rhaleb, C. Tousignant, S. Télémaque, G. Drapeau, D. Regoli, E. Naline, C. Advenier, P. Rovero, C.A. Maggi   +12 more
openaire   +2 more sources

[The structure-function organization of neurokinin A and neurokinin B molecules. II. Theoretical conformational analysis of neurokinin B].

Biofizika, 2005
The spatial structure of a neurokinin B molecule was investigated by the method of theoretical conformational analysis. The conformational analysis of this molecule indicated that the possible structure of neurokinin B under polar conditions may be described by five families of low-energy conformations possessing a conformationally relatively rigid C ...
G A, Agaeva, N N, Kerimli, N M, Godzhaev
openaire   +2 more sources