Neurokinin B is hydrolysed by synaptic membranes and by endopeptidase-24.11 (‘enkephalinase’) but not by angiotensin converting enzyme [PDF]
, 1985 Endopeptidase-24.11 (‘enkephalinase’, EC 3.4.24.11) from pig kidney hydrolysed neurokinin B at 4 sites:The major site of hydrolysis was the Gly8-Leu9 bond.
Hooper, Nigel M. +3 more
core +1 more source
Copper ions trigger disassembly of neurokinin B functional amyloid and inhibit de novo assembly [PDF]
, 2019 The formation of amyloid is considered an intrinsic ability of most polypeptides. It is a structure adopted by many neuropeptides and neurohormones during the formation of dense core vesicles in secretory cells, yet the mechanisms mediating assembly and ...
Jones, Christopher E. (R15179) +3 more
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Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis [PDF]
, 2017 Background: Hypothalamic kisspeptin and neurokinin B (NKB) are central regulators of GnRH and thus gonadotropin (LH and FSH) secretion. Men and women with loss-of-function mutations in NKB-kisspeptin pathway show hypogonadotropic pubertal delay with ...
Skorupskaite, Karolina
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Increased neurogenesis and brain-derived neurotrophic factor in neurokinin-1 receptor gene knockout mice [PDF]
, 2003 It has previously been shown that chronic treatment with antidepressant drugs increases neurogenesis and levels of brain-derived neurotrophic factor in the hippocampus.
Sheasby, Anne M. +11 more
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Neurokinin A selectively inhibits water intake in the rat [PDF]
, 1988 The results of the present study show that the intracerebroventricular injection of neurokinin A elicited a selective antidipsogenic effect in the rat.
POLIDORI, Carlo +3 more
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Internalization of the neurokinin 1 receptor in rat myenteric neurons [PDF]
, 1999 Internalization of the neurokinin 1 receptor in rat myenteric ...
BR Southwell (14473155) +2 more
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Placental human neurokinin b precursor [PDF]
, 2001 Methods of diagnosing pregnancy induced hypertension or pre-eclampsia by the measuremnt of the production of neurokinin B, its precursor and fragments thereof are provided, as are kits for use in the methods.
Lowry, Philip, Page, Nigel
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Neurokinin release in the rat nucleus of the solitary tract via NMDA and AMPA receptors. [PDF]
, 2002 International audienceNeurokinins (substance P, neurokinin A and neurokinin B) and the neurokinin receptors, the NK1 and NK3 receptors, are largely expressed in the nucleus of the solitary tract (NST) where they are involved in the central regulation of ...
Baude, Agnès, Blondeau, C., Colin, I.
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Open Medicine, 2018 To perform a prospective non-randomized comparison of the effectiveness and safety of combined neurokinin-1 antagonist aprepitant treatment with the standard multiple-day cisplatin regimen for the prevention of cisplatin-induced nausea and vomiting (CINV)
Li Quanfu +12 more
doaj +1 more source
A New Hope for Woman with Vasomotor Symptoms: Neurokinin B Antagonists [PDF]
KNDy (kisspeptine, neurokinin B, dynorphin) neurons, located in the hypothalamus, play a crucial role in the development of vasomotor symptoms (VSM) in menopausal women.
Christian Unogu +6 more
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