Results 1 to 10 of about 1,032,345 (337)

Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review

Discover Oncology, 2023
Purpose In the past decade, there has been little progress in the treatment of malignant glioma. Recently, oncolytic virus has made great progress in glioma treatment, and a number of clinical trials have shown their potential of prolonging the survival ...
Shan Jiang, Huihui Chai, Qisheng Tang, Zhifeng Shi, Liangfu Zhou   +4 more
doaj   +1 more source

Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study

BMC Medicine, 2023
Background Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural changes and which specific brain ...
Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang, Yi Tang   +8 more
doaj   +1 more source

Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Fluids and Barriers of the CNS, 2023
Background The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos ...
Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim, David L. Brody   +5 more
doaj   +1 more source

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Molecular Neurodegeneration, 2022
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery.
Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tang   +8 more
doaj   +1 more source

Causal relationship between gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: A bidirectional Mendelian randomization study

Brain and Behavior, 2023
Background The incidence of gastroesophageal reflux disease (GERD) has been shown to be elevated in individuals with epilepsy. Traditional observational studies have led to a limited understanding of the effects of GERD and BE on epilepsy due to the ...
Xiaoduo Liu, Tao Wei, Lubo Shi, Shaojiong Zhou, Yufei Liu, Weiyi Song, Xinwei Que, Zhibin Wang, Yi Tang   +8 more
doaj   +1 more source

Neurological manifestations and neuro-invasive mechanisms of the severe acute respiratory syndrome coronavirus type 2 [PDF]

, 2020
Background and purpose Infections with coronaviruses are not always confined to the respiratory tract and various neurological manifestations have been reported.
Boon, Paul, De Herdt, Veerle, Garrez, Ieme, Hemelsoet, Dimitri, Laureys, Guy, Raedt, Robrecht, Vonck, Kristl   +6 more
core   +2 more sources

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Communications Biology, 2021
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα.
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi   +11 more
doaj   +1 more source

Real-time visualization of exo- and endocytosis membrane dynamics with confocal and super-resolution microscopy

STAR Protocols, 2022
Summary: Real-time confocal and super-resolution imaging reveals membrane dynamics of exo- and endocytosis, including hemi-fusion, fusion pore opening, expansion, constriction, closure (kiss-and-run), fused-vesicle shrinking (shrink fusion), and flat ...
Xiaoli Guo, Sue Han, Lisi Wei, Gianvito Arpino, Wonchul Shin, Xin Wang, Ling-Gang Wu   +6 more
doaj   +1 more source

Modulation of adult-born neurons in the inflamed hippocampus. [PDF]

, 2013
Throughout life new neurons are continuously added to the hippocampal circuitry involved with spatial learning and memory. These new cells originate from neural precursors in the subgranular zone of the dentate gyrus, migrate into the granule cell layer,
Belarbi, Karim, Rosi, Susanna
core   +2 more sources

Value and efficacy of transcranial direct current stimulation in the rehabilitation of neurocognitive disorders: A critical review since 2000. [PDF]

, 2016
open3siNon-invasive brain stimulation techniques, including transcranial direct current stimulation (t-DCS) have been used in the rehabilitation of cognitive function in a spectrum of neurological disorders.
Davide Cappon, Marjan Jahanshahi, Patrizia Bisiacchi   +2 more
core   +2 more sources