Results 21 to 30 of about 2,302,356 (314)

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Communications Biology, 2021
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα.
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi   +11 more
doaj   +1 more source

Nutritional interventions for the prevention and treatment of neurological disorders such as anxiety, bipolar disorder, depression, epilepsy, multiple sclerosis, and schizophrenia

, 2022
Neurological disorders are a significant cause of mortality and disability across the world. The current aging population and population expansion have seen an increase in the prevalence of neurological and psychiatric disorders such as anxiety, bipolar ...
Sahithi Madireddy*, Samskruthi Madireddy
core   +1 more source

Scaling up services for mental and neurological disorders in low-resource settings. [PDF]

, 2009
Mental and neurological disorders (MNDs) account for a large, and growing, burden of disease in low- and middle-income countries. Most people do not have access to even basic health care for these disorders.
Vikram Patel, Desai, Rajnanda, Patel, Vikram, Goel, Digvijay Singh, Digvijay Singh Goel, Rajnanda Desai   +5 more
core   +2 more sources

Real-time visualization of exo- and endocytosis membrane dynamics with confocal and super-resolution microscopy

STAR Protocols, 2022
Summary: Real-time confocal and super-resolution imaging reveals membrane dynamics of exo- and endocytosis, including hemi-fusion, fusion pore opening, expansion, constriction, closure (kiss-and-run), fused-vesicle shrinking (shrink fusion), and flat ...
Xiaoli Guo, Sue Han, Lisi Wei, Gianvito Arpino, Wonchul Shin, Xin Wang, Ling-Gang Wu   +6 more
doaj   +1 more source

Photophobia in neurologic disorders [PDF]

Translational Neurodegeneration, 2017
Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestations of photophobia in neurological disorders, including primary headache, blepharospasm, progressive supranuclear palsy, and traumatic brain injury,
Yiwen Wu, Mark Hallett
openaire   +3 more sources

[Functional Neurological Disorders - A Common but Often Unrecognized Diagnosis].

, 2023
Functional Neurological Disorders - A Common but Often Unrecognized Diagnosis Abstract: Functional neurological disorders are frequent and diverse in the clinical presentation.
Gegusch, Michaela, Barth, Rike
core   +1 more source

Development of a sensitive outcome for economical drug screening for progressive multiple sclerosis treatment

Frontiers in Neurology, 2016
Therapeutic advance in progressive multiple sclerosis (MS) has been very slow. Based on the transformative role magnetic resonance imaging (MRI) contrast-enhancing lesions had on drug development for relapsing-remitting MS, we consider the lack of ...
Peter Kosa, Danish Ghazali, Makoto Tanigawa, Chris Barbour, Irene Cortese, William Kelley, Blake Snyder, Joan Ohayon, Kaylan Fenton, Tanya Lehky, Tianxia Wu, Mark Greenwood, Govind Nair, Bibiana Bielekova   +13 more
doaj   +1 more source

Periictal water drinking revisited: Occurrence and lateralizing value in surgically confirmed patients with focal epilepsy

Epilepsia Open, 2023
Objective Periictal water drinking (PIWD), which is a rare seizure‐related autonomic behavior, has been reported in temporal lobe epilepsy (TLE) but only rarely in extra‐TLE. Additionally, the lateralizing value of PIWD is controversial.
Yuhei Tanno, Takashi Matsudaira, Naotaka Usui, Hiroshi Ogawa, Kentaro Tokumoto, Norihiko Kawaguchi, Akihiko Kondo, Takuji Nishida, Yukitoshi Takahashi   +8 more
doaj   +1 more source

Recent Advancement of Neurofibromatosis Type 1: A Narrative Review

Acta Neurologica Taiwanica
Neurofibromatosis type 1 (NF1) is a complex autosomal dominant genetic disorder caused by mutations in the NF1 gene on chromosome 17, which encodes the tumor-suppressor protein, neurofibromin.
Po-Yuan Huang, Society for Neurological Rare Disorders-Taiwan, Ming-Jen Lee   +2 more
doaj   +1 more source

A Review of Spinocerebellar Ataxias in Taiwan

Acta Neurologica Taiwanica
Spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases characterized by inherited progressive cerebellar ataxia with or without other associated features. The clinical presentations of these affected SCA patients are very heterogeneous.
Chia-Ju Lee, Chin-San Liu, Society for Neurological Rare Disorders-Taiwan   +2 more
doaj   +1 more source