Results 21 to 30 of about 663,441 (269)

HHV‐6 and hippocampal volume in patients with mesial temporal sclerosis

Annals of Clinical and Translational Neurology, 2020
Objective To study the effects of human herpes virus 6 (HHV‐6) on the hippocampal volume in patients with mesial temporal sclerosis (MTS). Background HHV‐6 may play an etiologic role in MTS.
Elizabeth O. Akinsoji, Emily Leibovitch, B. Jeanne Billioux, Osorio Lopes Abath Neto, Abhik Ray‐Chaudhury, Sara K. Inati, Kareem Zaghloul, John Heiss, Steven Jacobson, William H. Theodore   +9 more
doaj   +1 more source

Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers

npj Parkinson's Disease, 2022
Non-manifesting carriers (NMCs) of Parkinson’s disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing ...
Amgad Droby, Moran Artzi, Hedva Lerman, R. Matthew Hutchison, Dafna Ben Bashat, Nurit Omer, Tanya Gurevich, Avi Orr-Urtreger, Batsheva Cohen, Jesse M. Cedarbaum, Einat Even Sapir, Nir Giladi, Anat Mirelman, Avner Thaler   +13 more
doaj   +1 more source

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

eLife, 2022
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the ...
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell   +8 more
doaj   +1 more source

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Calcineurin Is Universally Involved in Vesicle Endocytosis at Neuronal and Nonneuronal Secretory Cells

Cell Reports, 2014
Calcium influx triggers and accelerates endocytosis in nerve terminals and nonneuronal secretory cells. Whether calcium/calmodulin-activated calcineurin, which dephosphorylates endocytic proteins, mediates this process is highly controversial for ...
Xin-Sheng Wu, Zhen Zhang, Wei-Dong Zhao, Dongsheng Wang, Fujun Luo, Ling-Gang Wu   +5 more
doaj   +1 more source

Nutraceuticals in Neurological Disorders [PDF]

International Journal of Molecular Sciences, 2020
Neurological diseases are one of the major healthcare issues worldwide. Posed lifestyle changes are associated with drastically increased risk of chronic illness and diseases, posing a substantial healthcare and financial burden to society globally. Researchers aim to provide fine treatment for ailing disorders with minimal exposed side effects.
Rashita Makkar, Tapan Behl, Simona Bungau, Gokhan Zengin, Vineet Mehta, Arun Kumar, Md. Sahab Uddin, Ghulam Md. Ashraf, Mohamed M. Abdel-Daim, Sandeep Arora, Roxana Oancea   +10 more
openaire   +2 more sources

Admixture Mapping Reveals Candidate Regions for Methotrexate Neurotoxicity Susceptibility: A Reducing Disparities in Acute Leukemia Consortium Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris, Priya B. Shetty, Olga A. Taylor, Elizabeth G. Atkinson, Melissa A. Richard, M. Monica Gramatges, Mark Zobeck, Sandi Pruitt, Amy Hughes, M. Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Han Chen, Bing Yu, Philip J. Lupo, Karen R. Rabin, Michael E. Scheurer, Austin L. Brown, The REDIAL Consortium   +24 more
wiley   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

Systemic complement factors in aging, Alzheimer’s disease and other dementias: a longitudinal study over 10 years

Molecular Neurodegeneration
Background Complement dysregulation is increasingly recognized in Alzheimer’s disease (AD). However, the temporal profile of complement alterations preceding AD onset and their distinction from age-related immune changes remain poorly defined. Clarifying
Xiaofeng Fu, Huimin Cai, Shuiyue Quan, Weiyun Zhang, Yumei Geng, Qing Tian, Ziye Ren, Yinghao Xu, Chengyu An, Jiaqi Li, Changbiao Chu, Wei Wang, Yana Pang, QianQian Wang, Lu Lu, Qi Wang, Yan Li, Fangyu Li, Shuya Nie, Longfei Jia   +19 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source