Results 1 to 10 of about 663,441 (269)

Clinical advances in oncolytic virus therapy for malignant glioma: a systematic review

Discover Oncology, 2023
Purpose In the past decade, there has been little progress in the treatment of malignant glioma. Recently, oncolytic virus has made great progress in glioma treatment, and a number of clinical trials have shown their potential of prolonging the survival ...
Shan Jiang, Huihui Chai, Qisheng Tang, Zhifeng Shi, Liangfu Zhou   +4 more
doaj   +1 more source

Mitophagy in neurological disorders [PDF]

Journal of Neuroinflammation, 2021
AbstractSelective autophagy is an evolutionarily conserved mechanism that removes excess protein aggregates and damaged intracellular components. Most eukaryotic cells, including neurons, rely on proficient mitophagy responses to fine-tune the mitochondrial number and preserve energy metabolism. In some circumstances (such as the presence of pathogenic
Lijun Zhang, Lei Dai, Deyuan Li
openaire   +3 more sources

Causal effects of COVID-19 on structural changes in specific brain regions: a Mendelian randomization study

BMC Medicine, 2023
Background Previous studies have found a correlation between coronavirus disease 2019 (COVID-19) and changes in brain structure and cognitive function, but it remains unclear whether COVID-19 causes brain structural changes and which specific brain ...
Shaojiong Zhou, Tao Wei, Xiaoduo Liu, Yufei Liu, Weiyi Song, Xinwei Que, Yi Xing, Zhibin Wang, Yi Tang   +8 more
doaj   +1 more source

Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Fluids and Barriers of the CNS, 2023
Background The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos ...
Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim, David L. Brody   +5 more
doaj   +1 more source

TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target

Molecular Neurodegeneration, 2022
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane immune receptor that is mainly expressed on microglia in the brain and macrophages in the periphery.
Rui-Yang Li, Qi Qin, Han-Chen Yang, Ying-Ying Wang, Ying-Xin Mi, Yun-Si Yin, Meng Wang, Chao-Ji Yu, Yi Tang   +8 more
doaj   +1 more source

Driving and Neurologic Disorders [PDF]

Neurology, 2011
Automobile driving is an indispensable activity of daily life. Driving in the United States equates to independence, freedom, and, in most cases, economic livelihood. Yet vehicular crashes injure millions of people in the United States each year at a cost of more than $250 billion, resulting in 40,000 annual deaths.1 Many medical, neurologic, and ...
Joseph F, Drazkowski, Joseph I, Sirven
openaire   +2 more sources

Paraneoplastic Neurologic Disorders

Current Neurology and Neuroscience Reports, 2023
Abstract Purpose of Review To provide an overview and highlight recent updates in the field of paraneoplastic neurologic disorders. Recent Findings The prevalence of paraneoplastic neurologic disorders is greater than previously reported and the incidence has been rising over time ...
Michael Gilligan, Christopher McGuigan, Andrew McKeon   +2 more
openaire   +2 more sources

Apheresis in Neurological Disorders [PDF]

Journal of Clinical Medicine, 2020
Plasma exchange (PE) and immunoadsorption (IA) constitute important options in the treatment of various autoimmune disorders across different medical disciplines [...]
openaire   +3 more sources

Causal relationship between gastroesophageal reflux disease, Barrett's esophagus, and epilepsy: A bidirectional Mendelian randomization study

Brain and Behavior, 2023
Background The incidence of gastroesophageal reflux disease (GERD) has been shown to be elevated in individuals with epilepsy. Traditional observational studies have led to a limited understanding of the effects of GERD and BE on epilepsy due to the ...
Xiaoduo Liu, Tao Wei, Lubo Shi, Shaojiong Zhou, Yufei Liu, Weiyi Song, Xinwei Que, Zhibin Wang, Yi Tang   +8 more
doaj   +1 more source

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Communications Biology, 2021
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα.
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi   +11 more
doaj   +1 more source