Results 31 to 40 of about 663,441 (269)

Mapping the developmental path for Parkinson’s disease therapeutics

npj Parkinson's Disease
The National Institute of Neurological Disorders and Stroke (NINDS) held an open workshop on April 23 and 24, 2024 to evaluate the gap between the current understanding of Parkinson’s disease (PD) and the development of therapeutics for treating PD ...
Neel T. Dhruv, Sarah Robinson Schwartz, Christine Swanson-Fischer, Hyun Joo Cho, Rebekah Corlew, Lyn Jakeman, Lauren A. Laboissonniere, Rebecca Price, Shireen Sarraf, Beth-Anne Sieber, Christine Torborg, Carl Wonders, Alice Chen-Plotkin, William J. Martin, Amir P. Tamiz   +14 more
doaj   +1 more source

Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis

Nature Communications, 2018
During development, dendrites display structural plasticity, as reflected in the appearance of long, thin and highly motile dendritic filopodia. Here, the authors examine dendritic dynamics of ventral lateral neurons in the developing Drosophila larva ...
Chengyu Sheng, Uzma Javed, Mary Gibbs, Caixia Long, Jun Yin, Bo Qin, Quan Yuan   +6 more
doaj   +1 more source

Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease

Alzheimer’s Research & Therapy, 2023
Background Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer’s disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit ...
Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia   +15 more
doaj   +1 more source

Secretory Phospholipase A2 in Patients With Sickle Cell Disease Hospitalized for Vaso‐Occlusive Pain Episodes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Secretory phospholipase A2 (sPLA2) is an inflammatory mediator linked to acute chest syndrome (ACS) in sickle cell disease (SCD), a serious complication that can develop during an acute vaso‐occlusive pain episode (VOE). Plasma sPLA2 levels have been proposed as a potential biomarker for predicting ACS onset.
Rawan Korman, Maria Yasmine, Dunia Hatabah, Noor Alzraikat, Frank Harris, Lou Ann Brown, Satheesh Chonat, Nitya Bakshi, Chris A. Rees, Carlton Dampier, Claudia R. Morris   +10 more
wiley   +1 more source

Duloxetine and venlafaxine induced akathisia: two case reports

Psychiatry and Clinical Psychopharmacology, 2021
Akathisia is a movement disorder characterized by involuntary movements resulting in discomfort and restlessness. Drug-induced akathisia is often seen with antidopaminergic antipsychotics but sometimes can be seen with other drugs.
Filiz Izci, Selma Bozkurt Zincir, Guler Acar, Umit Basar Semiz   +3 more
doaj   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source

Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank

Alzheimer’s Research & Therapy
Background Existing evidence highlights associations between sleep behaviors and dementia risk; however, the impact of adhering to a healthy sleep pattern on dementia risk remains unclear.
Tao Wei, Jie Chang, Yiwei Zhao, Aonan Li, Wei Sun, Xiaoduo Liu, Hongjia Liu, Yi Xing, Zhibin Wang, Yi Tang   +9 more
doaj   +1 more source

A systematic review of the role of TREM2 in Alzheimer’s disease

Chinese Medical Journal
. Background:. Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a
Yunsi Yin, Hanchen Yang, Ruiyang Li, Guangshan Wu, Qi Qin, Yi Tang, Ting Gao, Xiuyuan Hao   +7 more
doaj   +1 more source

Robust, atlas-free, automatic segmentation of brain MRI in health and disease

Heliyon, 2019
Background: Brain- and lesion-volumes derived from magnetic resonance images (MRI) serve as important imaging markers of disease progression in neurodegenerative diseases and aging.
Kartiga Selvaganesan, Emily Whitehead, Paba M. DeAlwis, Matthew K. Schindler, Souheil Inati, Ziad S. Saad, Joan E. Ohayon, Irene C.M. Cortese, Bryan Smith, Steven Jacobson, Avindra Nath, Daniel S. Reich, Sara Inati, Govind Nair   +13 more
doaj   +1 more source

Therapeutic Apheresis in Nigeria: A Multi‐Center Summary of Abstracts From the Inaugural Nigerian Society for Apheresis Scientific Meeting

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye, Chimezie Okwuonu, Evelyn Idam, Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Zinnah Aloziem, Blossom Amamchukwu, Patience Elimia, Mkpoikanabasi Obot‐Obot, Henry Mbakwe, Praises Maduagwuna, Olatunji Akinrodoye, Chiamaka Anyanwu, Benjamin Anyanwu, Adedamola Akinsiku, Oluwatoyin A. Akinsiku, Muzamil O. Hassan, Fatiu A. Arogundade, Olalekan E. Ojo, Homayemem Weli, Jesupelumi Adenihun, Aderemi Adelaja, Ebun Bamgboye, Olalekan Olatise, Ade E. Faponle, Ayoola Odeyemi, Michael Muoka, Stephen Asaolu, Qudrat Busari, Blessing Dawudu, Michael Naiyeju, Rasheed A. Balogun   +33 more
wiley   +1 more source