Results 31 to 40 of about 4,670,463 (363)

Global, regional, and national burden of neurological disorders, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Lancet Neurology, 2017
Summary Background Neurological disorders are increasingly recognised as major causes of death and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 is to provide the most ...
V. Feigin, A. Abajobir, K. H. Abate, F. Abd-Allah, A. Abdulle, S. Abera, G. Abyu, M. Ahmed, Amani Nidhal Aichour, Ibtihel Aichour, Miloud Taki Eddine Aichour, R. Akinyemi, S. Alabed, R. Al-Raddadi, N. Alvis-Guzmán, A. Amare, H. Ansari, P. Anwari, J. Ärnlöv, H. Asayesh, S. W. Asgedom, T. Atey, L. Ávila-Burgos, Euripide Frinel, G. A. Avokpaho, M. Azarpazhooh, A. Barać, M. Barboza, S. Barker-Collo, T. Bärnighausen, Neeraj Bedi, E. Beghi, D. Bennett, I. Benseñor, A. Berhane, B. Betsu, S. Bhaumik, Sait Mentes Birlik, S. Biryukov, D. Boneya, L. Bulto, H. Carabin, Daniel C. Casey, C. Castañeda-Orjuela, F. Catalá-López, Honglei Chen, Abdulaal Chitheer, Rajiv Chowdhury, H. Christensen, L. Dandona, R. Dandona, G. Veber, S. Dharmaratne, H. Do, K. Dokova, E. Dorsey, R. Ellenbogen, S. Eskandarieh, M. Farvid, S. Fereshtehnejad, F. Fischer, Kyle Foreman, J. Geleijnse, R. Gillum, G. Giussani, Ellen M. Goldberg, P. Gona, A. Goulart, H. Gugnani, Rahul Gupta, V. Hachinski, R. Gupta, R. Hamadeh, M. Hambisa, G. Hankey, H. Hareri, Rasmus J. Havmoeller, Simon Iain Hay, P. Heydarpour, P. Hotez, M. Jakovljevic, Mehdi Javanbakht, P. Jeemon, J. Jonas, Yogeshwar V. Kalkonde, A. Kandel, A. Karch, A. Kasaeian, A. Kastor, P. Keiyoro, Y. Khader, I. Khalil, E. Khan, Y. Khang, Abdullah Tawfih, A. Khoja, J. Khubchandani, Chanda Kulkarni, Daniel H. Kim, Y. Kim, M. Kivimäki, Y. Kokubo, S. Kosen, M. Kravchenko, R. Krishnamurthi, B. K. Defo, G. Kumar, Rashmi Kumar, H. Kyu, A. Larsson, P. Lavados, Yongmei Li, Xiaofeng Liang, Misgan Legesse Liben, W. Lo, G. Logroscino, P. Lotufo, C. Loy, M. Mackay, H. A. E. Razek, M. Razek, A. Majeed, R. Malekzadeh, Treh Manhertz, L. Mantovani, J. Massano, M. Mazidi, C. McAlinden, S. Mehata, M. Mehndiratta, Ziad A. Memish, W. Mendoza, Mubarek Abera Mengistie, G. Mensah, A. Meretoja, H. Mezgebe, Ted R. Miller, S. Mishra, N. Ibrahim, A. Mohammadi, Kedir Mohammed Oumer, S. Mohammed, A. Mokdad, M. Moradi-Lakeh, I. M. Velásquez, K. Musa, M. Naghavi, J. Ngunjiri, Cuong Tat Nguyen, Grant Nguyen, Q. Nguyen, T. Nguyen, Emma Nichols, D. N. A. Ningrum, V. M. Nong, B. Norrving, J. Noubiap, F. Ogbo, M. Owolabi, J. Pandian, P. Parmar, David M Pereira, Max Petzold, M. Phillips, M. Piradov, R. Poulton, F. Pourmalek, M. Qorbani, Anwar Rafay, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, R. Rai, Sasa Rajsic, Annemarei Ranta, S. Rawaf, Andre M. N. Renzaho, M. S. Rezai, Gregory A. Roth, G. Roshandel, Enrico Rubagotti, P. Sachdev, Saeid Safiri, R. Sahathevan, M. Sahraian, A. Samy, Paula Santalucia, I. Santos, B. Sartorius, Maheswar Satpathy, M. Sawhney, M. Saylan, S. Sepanlou, M. Shaikh, R. Shakir, M. Shamsizadeh, K. Sheth, M. Shigematsu, Haitham Shoman, D. Silva, Mari Smith, E. Sobngwi, L. Sposato, J. Stanaway, D. Stein, T. Steiner, L. Stovner, R. Abdulkader, C. Szoeke, R. Tabarés-Seisdedos, D. Tanné, A. Theadom, A. Thrift, D. Tirschwell, R. Topor-Madry, B. Tran, T. Truelsen, K. Tuem, K. Ukwaja, O. Uthman, Yuri Y Varakin, T. Vasankari, N. Venketasubramanian, V. Vlassov, F. Wadilo, Tolassa Wakayo, M. Wallin, E. Weiderpass, R. Westerman, T. Wijeratne, C. Wiysonge, M. Woldu, C. Wolfe, D. Xavier, Gelin Xu, Y. Yano, H. H. Yimam, N. Yonemoto, Chuanhua Yu, Z. Zaidi, M. Zaki, J. Zunt, C. Murray, T. Vos   +242 more
semanticscholar   +1 more source

Myopathy associated LDB3 mutation causes Z-disc disassembly and protein aggregation through PKCα and TSC2-mTOR downregulation

Communications Biology, 2021
Pathak et al. identify LDB3, a striated muscle PDZ-LIM protein, as a signaling adaptor in a major mechanosensor assembly through interactions with filamin C, HSPA8, and PKCα.
Pankaj Pathak, Yotam Blech-Hermoni, Kalpana Subedi, Jessica Mpamugo, Charissa Obeng-Nyarko, Rachel Ohman, Ilda Molloy, Malcolm Kates, Jessica Hale, Stacey Stauffer, Shyam K. Sharan, Ami Mankodi   +11 more
doaj   +1 more source

The function of gut microbiota in immune-related neurological disorders: a review

Journal of Neuroinflammation, 2022
This review provides an overview of the importance of microbiota in the regulation of gut–brain communication in immune-related neurological disorders. The gastrointestinal (GI) tract hosts a diverse abundance of microbiota, referred to as gut microbiota.
Panida Sittipo, Jaeyoon Choi, Soojin Lee, Y. Lee   +3 more
semanticscholar   +1 more source

Enteric Nervous System: The Bridge Between the Gut Microbiota and Neurological Disorders

Frontiers in Aging Neuroscience, 2022
The gastrointestinal (GI) tract plays an essential role in food digestion, absorption, and the mucosal immune system; it is also inhabited by a huge range of microbes.
Zifan Geng, Yan Zhu, Quan-Lin Li, Chao Zhao, P. Zhou   +4 more
semanticscholar   +1 more source

Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders

Nature Neuroscience, 2021
Understanding the tissue-specific genetic controls of protein levels is essential to uncover mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic atlas of protein levels in three tissues relevant to neurological ...
Chengran Yang, F. Farias, L. Ibañez, Adam Suhy, B. Sadler, M. Fernández, Fengxian Wang, Joseph Bradley, B. Eiffert, J. Bahena, J. Budde, Zeran Li, U. Dube, Y. Sung, K. Mihindukulasuriya, J. Morris, A. Fagan, R. Perrin, B. Benitez, H. Rhinn, O. Harari, Carlos Cruchaga   +21 more
semanticscholar   +1 more source

Real-time visualization of exo- and endocytosis membrane dynamics with confocal and super-resolution microscopy

STAR Protocols, 2022
Summary: Real-time confocal and super-resolution imaging reveals membrane dynamics of exo- and endocytosis, including hemi-fusion, fusion pore opening, expansion, constriction, closure (kiss-and-run), fused-vesicle shrinking (shrink fusion), and flat ...
Xiaoli Guo, Sue Han, Lisi Wei, Gianvito Arpino, Wonchul Shin, Xin Wang, Ling-Gang Wu   +6 more
doaj   +1 more source

Genomics in Neurological Disorders

Genomics, Proteomics & Bioinformatics, 2014
Abstract Neurological disorders comprise a variety of complex diseases in the central nervous system, which can be roughly classified as neurodegenerative diseases and psychiatric disorders. The basic and translational research of neurological disorders has been hindered by the difficulty in accessing the pathological center (i.e., the ...
Guangchun Han, Jiya Sun, Jiajia Wang, Zhouxian Bai, Fuhai Song, Hongxing Lei   +5 more
openaire   +3 more sources

Targeting Molecular Mediators of Ferroptosis and Oxidative Stress for Neurological Disorders

Oxidative Medicine and Cellular Longevity, 2022
With the acceleration of population aging, nervous system diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), anxiety, depression, stroke, and traumatic brain injury (TBI) have become a huge burden on ...
Jing Li, B. Jia, Ying Cheng, Yiting Song, Qianqian Li, Chengliang Luo   +5 more
semanticscholar   +1 more source

Dimethyl fumarate and mitochondrial physiology: implications for neurological disorders. [PDF]

Front Pharmacol
de Oliveira MR.
europepmc   +3 more sources

Th17 cells and inflammation in neurological disorders: Possible mechanisms of action

Frontiers in Immunology, 2022
Neurological disorders (NDs) are one of the leading causes of global death. A sustained neuroinflammatory response has been reported to be associated with the pathogenesis of multiple NDs, including Parkinson’s disease (PD), multiple sclerosis (MS ...
Yajun Shi, B. Wei, Lingjun Li, Bin Wang, Miao Sun   +4 more
semanticscholar   +1 more source