Results 51 to 60 of about 2,206,438 (308)

Mapping the developmental path for Parkinson’s disease therapeutics

npj Parkinson's Disease
The National Institute of Neurological Disorders and Stroke (NINDS) held an open workshop on April 23 and 24, 2024 to evaluate the gap between the current understanding of Parkinson’s disease (PD) and the development of therapeutics for treating PD ...
Neel T. Dhruv, Sarah Robinson Schwartz, Christine Swanson-Fischer, Hyun Joo Cho, Rebekah Corlew, Lyn Jakeman, Lauren A. Laboissonniere, Rebecca Price, Shireen Sarraf, Beth-Anne Sieber, Christine Torborg, Carl Wonders, Alice Chen-Plotkin, William J. Martin, Amir P. Tamiz   +14 more
doaj   +1 more source

Experience-dependent structural plasticity targets dynamic filopodia in regulating dendrite maturation and synaptogenesis

Nature Communications, 2018
During development, dendrites display structural plasticity, as reflected in the appearance of long, thin and highly motile dendritic filopodia. Here, the authors examine dendritic dynamics of ventral lateral neurons in the developing Drosophila larva ...
Chengyu Sheng, Uzma Javed, Mary Gibbs, Caixia Long, Jun Yin, Bo Qin, Quan Yuan   +6 more
doaj   +1 more source

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model

Journal of Neuroinflammation, 2023
Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored.
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao   +9 more
doaj   +1 more source

Preclinical Research on Focused Ultrasound-Mediated Blood–Brain Barrier Opening for Neurological Disorders: A Review

, 2023
Several therapeutic agents for neurological disorders are usually not delivered to the brain owing to the presence of the blood–brain barrier (BBB), a special structure present in the central nervous system (CNS).
Chanho Kong, Won Seok Chang
core   +1 more source

Effectiveness of Resistance Intradialytic Exercise Compared to Aerobic Intradialytic Exercise for Patients With Chronic Kidney Disease: A Randomized Controlled Clinical Trial

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida, Gisela Cristiane Miyamoto, Daniel da Costa Torres, Ian Setubal Reis Chaves, Jonas do Carmo Paschoalin, Braúlio Lima Nascimento, Luciana Dias Chiavegato   +6 more
wiley   +1 more source

Global, regional, and national burden of neurological disorders during 1990-2015 [Elektronisk resurs] : a systematic analysis for the Global Burden of Disease Study 2015

, 2017
BACKGROUND: Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation.
GBD 2015 Neurological Disorders Collaborator Group, Feigin, Valery L.,, Lund University., Vos, Theo,, Jakovljevic, Mihajlo (Michael),, Norrving, Bo,   +5 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank

Alzheimer’s Research & Therapy
Background Existing evidence highlights associations between sleep behaviors and dementia risk; however, the impact of adhering to a healthy sleep pattern on dementia risk remains unclear.
Tao Wei, Jie Chang, Yiwei Zhao, Aonan Li, Wei Sun, Xiaoduo Liu, Hongjia Liu, Yi Xing, Zhibin Wang, Yi Tang   +9 more
doaj   +1 more source

A systematic review of the role of TREM2 in Alzheimer’s disease

Chinese Medical Journal
. Background:. Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a
Yunsi Yin, Hanchen Yang, Ruiyang Li, Guangshan Wu, Qi Qin, Yi Tang, Ting Gao, Xiuyuan Hao   +7 more
doaj   +1 more source

Robust, atlas-free, automatic segmentation of brain MRI in health and disease

Heliyon, 2019
Background: Brain- and lesion-volumes derived from magnetic resonance images (MRI) serve as important imaging markers of disease progression in neurodegenerative diseases and aging.
Kartiga Selvaganesan, Emily Whitehead, Paba M. DeAlwis, Matthew K. Schindler, Souheil Inati, Ziad S. Saad, Joan E. Ohayon, Irene C.M. Cortese, Bryan Smith, Steven Jacobson, Avindra Nath, Daniel S. Reich, Sara Inati, Govind Nair   +13 more
doaj   +1 more source