Results 61 to 70 of about 4,670,463 (363)

Role of Endogenous Lipopolysaccharides in Neurological Disorders

Cells, 2022
Lipopolysaccharide (LPS) is a cell-wall immunostimulatory endotoxin component of Gram-negative bacteria. A growing body of evidence reveals that alterations in the bacterial composition of the intestinal microbiota (gut dysbiosis) disrupt host immune ...
Manjunath Kalyan, Ahmed Hediyal Tousif, S. Sonali, C. Vichitra, Tuladhar Sunanda, Sankar Simla Praveenraj, Bipul Ray, V. Gorantla, W. Rungratanawanich, A. Mahalakshmi, M. W. Qoronfleh, T. Monaghan, B. Song, M. Essa, Saravanabau Chidambaram   +14 more
semanticscholar   +1 more source

Aberrant dopamine transporter and functional connectivity patterns in LRRK2 and GBA mutation carriers

npj Parkinson's Disease, 2022
Non-manifesting carriers (NMCs) of Parkinson’s disease (PD)-related mutations such as LRRK2 and GBA are at an increased risk for developing PD. Dopamine transporter (DaT)-spectral positron emission computed tomography is widely used for capturing ...
Amgad Droby, Moran Artzi, Hedva Lerman, R. Matthew Hutchison, Dafna Ben Bashat, Nurit Omer, Tanya Gurevich, Avi Orr-Urtreger, Batsheva Cohen, Jesse M. Cedarbaum, Einat Even Sapir, Nir Giladi, Anat Mirelman, Avner Thaler   +13 more
doaj   +1 more source

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

eLife, 2022
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the ...
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell   +8 more
doaj   +1 more source

The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders

Antioxidants
Central neurological disorders are significant contributors to morbidity, mortality, and long-term disability globally in modern society. These encompass neurodegenerative diseases, ischemic brain diseases, traumatic brain injury, epilepsy, depression ...
Yejia Xu, B. Jia, Jing Li, Qianqian Li, Chengliang Luo   +4 more
semanticscholar   +1 more source

Neurofilament light chain as a biomarker in neurological disorders

Journal of Neurology Neurosurgery & Psychiatry, 2019
In the management of neurological diseases, the identification and quantification of axonal damage could allow for the improvement of diagnostic accuracy and prognostic assessment.
L. Gaetani, K. Blennow, P. Calabresi, M. Di Filippo, L. Parnetti, H. Zetterberg   +5 more
semanticscholar   +1 more source

Ferroptosis Mediated by Lipid Reactive Oxygen Species: A Possible Causal Link of Neuroinflammation to Neurological Disorders

Oxidative Medicine and Cellular Longevity, 2021
Increasing evidence indicates a possible causal link between neuroinflammation and neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and stroke.
Ying Cheng, Yiting Song, Huan Chen, Qianqian Li, Yuan Gao, Guanchao Lu, Chengliang Luo   +6 more
semanticscholar   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

The gut microbiota–brain axis in neurological disorders

MedComm
Previous studies have shown a bidirectional communication between human gut microbiota and the brain, known as the microbiota–gut–brain axis (MGBA). The MGBA influences the host's nervous system development, emotional regulation, and cognitive function ...
Mingming You, Nan Chen, Yuanyuan Yang, Lingjun Cheng, Hongzhang He, Yanhua Cai, Yating Liu, Haiyue Liu, Guolin Hong   +8 more
semanticscholar   +1 more source

Viral infections and their relationship to neurological disorders

Archives of Virology, 2021
The chronic dysfunction of neuronal cells, both central and peripheral, a characteristic of neurological disorders, may be caused by irreversible damage and cell death.
Jéssica Wouk, D. Z. Rechenchoski, Bianca Cerqueira Dias Rodrigues, Elisa Vicente Ribelato, L. Faccin-Galhardi   +4 more
semanticscholar   +1 more source

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho, Karim M. Soliman, Wisit Cheungpasitporn, Wannasit Wathanavasin, Ahmed Daoud, Ahmed I. Kamal, Balázs Szamosfalvi, Tibor Fülöp   +7 more
wiley   +1 more source