Results 61 to 70 of about 2,302,356 (314)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Surrogates of glymphatic metrics decline and coupled sleep rhythms disruption in Alzheimer’s disease

Alzheimer’s Research & Therapy
Background Sleep is essential for brain homeostasis, in part by supporting glymphatic clearance through sleep-related oscillations. However, the relationship between putative glymphatic metrics and coupled sleep rhythm disruption, and their combined role
Xiaoduo Liu, Tao Wei, Bo Zhao, Shaojiong Zhou, Lei Liu, Yi Tang   +5 more
doaj   +1 more source

Shared and unique effects of ApoEε4 and pathogenic gene mutation on cognition and imaging in preclinical familial Alzheimer’s disease

Alzheimer’s Research & Therapy, 2023
Background Neuropsychology and imaging changes have been reported in the preclinical stage of familial Alzheimer’s disease (FAD). This study investigated the effects of APOEε4 and known pathogenic gene mutation on different cognitive domains and circuit ...
Meina Quan, Qi Wang, Wei Qin, Wei Wang, Fangyu Li, Tan Zhao, Tingting Li, Qiongqiong Qiu, Shuman Cao, Shiyuan Wang, Yan Wang, Hongmei Jin, Aihong Zhou, Jiliang Fang, Longfei Jia, Jianping Jia   +15 more
doaj   +1 more source

Advanced Topics in Neurological Disorders

, 2012
This book presents recent advances in the field of Neurological disorders research. It consists of 9 chapters encompassing a wide range of areas including bioengineering, stem cell transplantation, gene therapy, proteomic analysis, alternative treatment ...

core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bulk regional viral injection in neonatal mice enables structural and functional interrogation of defined neuronal populations throughout targeted brain areas

Frontiers in Neural Circuits, 2015
The ability to label and manipulate specific cell types is central to understanding the structure and function of neuronal circuits. Here, we have developed a simple, affordable strategy for labeling of genetically-defined populations of neurons ...
Claire E J Cheetham, Claire E J Cheetham, Bryce D Grier, Leonardo eBelluscio   +3 more
doaj   +1 more source

Distribution of types of costs in brain disorders, neurological disorders and mental disorders.

, 2014
Distribution of types of costs in brain disorders, neurological disorders and mental disorders.
Petra Jerinic (617133), Anders Gustavsson (617134), Oleguer Parés-Badell (617131), Luis Salvador-Carulla (454798), Gabriela Barbaglia (617132), Jordi Alonso (178939)   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Microglia/macrophages require vitamin D signaling to restrain neuroinflammation and brain injury in a murine ischemic stroke model

Journal of Neuroinflammation, 2023
Vitamin D deficiency is associated with worse clinical outcomes after ischemic stroke; nevertheless, the pathophysiological mechanisms remain largely unexplored.
Pan Cui, Wanting Lu, Junjie Wang, Fei Wang, Xiyue Zhang, Xiaodan Hou, Fang Xu, Yan Liang, Guoliang Chai, Junwei Hao   +9 more
doaj   +1 more source

Lipid Metabolic Alterations in the ALS–FTD Spectrum of Disorders

Biomedicines, 2022
There is an increasing interest in the study of the relation between alterations in systemic lipid metabolism and neurodegenerative disorders, in particular in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD).
Juan Miguel Godoy-Corchuelo, Luis C. Fernández-Beltrán, Zeinab Ali, María J. Gil-Moreno, Juan I. López-Carbonero, Antonio Guerrero-Sola, Angélica Larrad-Sainz, Jorge Matias-Guiu, Jordi A. Matias-Guiu, Thomas J. Cunningham, Silvia Corrochano   +10 more
doaj   +1 more source