Results 71 to 80 of about 2,206,438 (308)

Clathrin mediates membrane fission and budding by constricting membrane pores

Cell Discovery
Membrane budding, which underlies fundamental processes like endocytosis, intracellular trafficking, and viral infection, is thought to involve membrane coat-forming proteins, including the most observed clathrin, to form Ω-shape profiles and helix ...
Lisi Wei, Xiaoli Guo, Ehud Haimov, Kazuki Obashi, Sung Hoon Lee, Wonchul Shin, Min Sun, Chung Yu Chan, Jiansong Sheng, Zhen Zhang, Ammar Mohseni, Sudhriti Ghosh Dastidar, Xin-Sheng Wu, Xin Wang, Sue Han, Gianvito Arpino, Bo Shi, Maryam Molakarimi, Jessica Matthias, Christian A. Wurm, Lin Gan, Justin W. Taraska, Michael M. Kozlov, Ling-Gang Wu   +23 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Recent advances in regulating the proliferation or maturation of human-induced pluripotent stem cell-derived cardiomyocytes

Stem Cell Research & Therapy, 2023
In the last decade, human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM)-based cell therapy has drawn broad attention as a potential therapy for treating injured hearts.
Hao Yang, Yuan Yang, Fedir N. Kiskin, Mengcheng Shen, Joe Z. Zhang   +4 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer’s disease

Molecular Neurodegeneration
Background The blood-brain barrier (BBB) damage is frequently observed in Alzheimer’s disease (AD). However, it remains unclear whether plasma platelet-derived growth factor receptor-β (PDGFRβ) level is related to BBB damage and how it correlates with AD
Jieyin Li, Anqi Li, Chenghui Ye, Laihong Zhang, Mingxing Jiang, Guoyu Lan, Fernando Gonzalez-Ortiz, Jie Yang, Yalin Zhu, Yue Cai, Pan Sun, Lin Liu, Zhengbo He, Xin Zhou, Lili Fang, Yiying Wang, Zhen Liu, Kaj Blennow, Shaohua Ma, Xuhui Chen, Dai Shi, Tengfei Guo   +21 more
doaj   +1 more source

Modulation of functionally localized right insular cortex activity using real-time fMRI-based neurofeedback

Frontiers in Human Neuroscience, 2013
The capacity for subjects to learn to volitionally control localized brain activity using neurofeedback is actively being investigated. We aimed to investigate the ability of healthy volunteers to quickly learn to use visual feedback during real-time ...
Brian D Berman, Brian D Berman, Silvina G Horovitz, Mark eHallett   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Causal relationships between type 1 diabetes mellitus and Alzheimer’s disease and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study

European Journal of Medical Research
Background Previous compelling evidence suggests an association between Type 2 diabetes (T2D) and neurodegenerative diseases. However, it remains uncertain whether Type 1 diabetes mellitus (T1DM) exerts a causal influence on the risk of Alzheimer's ...
Chaofan Geng, Ke Meng, Bo Zhao, Xiaoduo Liu, Yi Tang   +4 more
doaj   +1 more source

The movement for global mental health. [PDF]

, 2011
The Movement for Global Mental Health is a coalition of individuals and institutions committed to collective actions that aim to close the treatment gap for people living with mental disorders worldwide, based on two fundamental principles: evidence on ...
Vikram Patel, Collins, Pamela Y, Pamela Y. Collins, Jagannath Lamichhane, Ritsuko Kakuma, Sarah Skeen, Katontoka, Sylvester, Copeland, John, John Copeland, Naik, Smita, Patel, Vikram, Lamichhane, Jagannath, Sylvester Katontoka, Smita Naik, Skeen, Sarah, Kakuma, Ritsuko   +15 more
core   +1 more source