Results 81 to 90 of about 2,206,438 (308)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Depression and neurological disorders

Neurosciences, 2009
Depression is the most common psychiatric disorder in neurological disorders such as epilepsy, multiple sclerosis, stroke, and Parkinsons disease. It is associated with reduction of quality of life, functional impairment, and higher mortality. The diagnosis of depression in neurological disorders is difficult because of the overlapping symptoms ...
openaire   +2 more sources

Clinical Utility and Lifespan Profiling of Neurological Soft Signs in Schizophrenia Spectrum Disorders [PDF]

, 2016
Neurological soft signs (NSSs) bear the promise for early detection of schizophrenia spectrum disorders. Nonetheless, the sensitivity and specificity of NSSs in the psychosis continuum remains a topic of controversy.
Yu, Xin, Chan, Raymond C. K., Wang, Chuan-yue, Rosenthal, Robert, Wang, Ya, Chan, Raymond C.K., Lui, Simon SY, Cheung, Eric F.C., Geng, Fu Lei, Wang, Chuan Yue, Xie, Weizhen, Geng, Fu-lei, Cheung, Eric F. C., Chan, Raymond CK, Cheung, Eric FC, Lui, Simon S. Y., Lui, Simon S.Y.   +16 more
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From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

npj Parkinson's Disease, 2017
Weight lossisa multifactorial disorder commonly affecting Parkinson’s disease patients. The aim of this study was to investigate the relationship between body weight, nutritional status, physical activity, and Parkinson’s disease-related factors. A total
Andrea Bril, Santiago Perez-Lloret, Malco Rossi, Sofía Fariña, Pierre Morisset, Laura Sorrentino, Micaela Iglesias, Alex Medina Escobar, Patricio Millar Vernetti, Daniel Cerquetti, Marcelo Merello   +10 more
doaj   +1 more source

Neurosteroids and neurological disorders

The Korean Journal of Physiology & Pharmacology
Neurosteroids play an important role as endogenous neuromodulators that are locally produced in the central nervous system and rapidly change the excitability of neurons and the activation of microglial cells and astrocytes. Here we review the mechanisms of synthesis, metabolism, and actions of neurosteroids in the central nervous system. Neurosteroids
Park, Gi Wan, Kim, Hayoung, Won, Seong Hyun, Kim, Nam Hyun, Choi, Sheu-Ran   +4 more
openaire   +2 more sources

Effectiveness of Vitamin D on Neurological and Mental Disorders

(1) Background: Mental disorders are conditions that affect a person’s cognition, mood, and behaviour, such as depression, anxiety, bipolar disorder, and schizophrenia. In contrast, neurological disorders are diseases of the brain, spinal cord, and
Shareefa Abdullah AlGhamdi
core   +1 more source

Angiogenesis in neurological disorders: A review

, 2012
Angiogenesis, recruitment of new blood vessels, is an essential component of the metastatic pathway. These vessels provide the principal route by which tumor cells exit the primary tumor site and enter the circulation.
Acar, Göksemin, Demir, R., Tanriöver, G.   +2 more
core   +1 more source

Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients

npj Parkinson's Disease
Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson’s disease (PD) and can be detected through synuclein amplification assays (SAA).
Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler   +17 more
doaj   +1 more source

Neurological Disorders in Famous Artists - Part 3 /

, 2010
The third part of 'Neurological Disorders in Famous Artists' presents painters, musicians, and writers who had to fight against an acute or chronic neurological disease. Sometimes this fight was without success (e.g. Shostakovich, Schumann, Wolf, Pascal),
Bogousslavsky, J.
core