Results 81 to 90 of about 4,670,463 (363)

The global burden of neurological disorders: translating evidence into policy

Lancet Neurology, 2019
Neurological disorders are the leading cause of disability and the second leading cause of death worldwide. In the past 30 years, the absolute numbers of deaths and people with disabilities owing to neurological diseases have risen substantially ...
V. Feigin, T. Vos, Emma Nichols, M. Owolabi, W. Carroll, M. Dichgans, G. Deuschl, P. Parmar, M. Brainin, C. Murray   +9 more
semanticscholar   +1 more source

Association of Oxidative Stress with Neurological Disorders

Current Neuropharmacology, 2021
Backgorund: Oxidative stress is one of the main contributing factors involved in cerebral biochemical impairment. The higher susceptibility of the central nervous system to reactive oxygen species mediated damage could be attributed to several factors ...

semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Associations of adherence to a healthy sleep pattern with the dementia risk in the UK biobank

Alzheimer’s Research & Therapy
Background Existing evidence highlights associations between sleep behaviors and dementia risk; however, the impact of adhering to a healthy sleep pattern on dementia risk remains unclear.
Tao Wei, Jie Chang, Yiwei Zhao, Aonan Li, Wei Sun, Xiaoduo Liu, Hongjia Liu, Yi Xing, Zhibin Wang, Yi Tang   +9 more
doaj   +1 more source

Robust, atlas-free, automatic segmentation of brain MRI in health and disease

Heliyon, 2019
Background: Brain- and lesion-volumes derived from magnetic resonance images (MRI) serve as important imaging markers of disease progression in neurodegenerative diseases and aging.
Kartiga Selvaganesan, Emily Whitehead, Paba M. DeAlwis, Matthew K. Schindler, Souheil Inati, Ziad S. Saad, Joan E. Ohayon, Irene C.M. Cortese, Bryan Smith, Steven Jacobson, Avindra Nath, Daniel S. Reich, Sara Inati, Govind Nair   +13 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Surrogates of glymphatic metrics decline and coupled sleep rhythms disruption in Alzheimer’s disease

Alzheimer’s Research & Therapy
Background Sleep is essential for brain homeostasis, in part by supporting glymphatic clearance through sleep-related oscillations. However, the relationship between putative glymphatic metrics and coupled sleep rhythm disruption, and their combined role
Xiaoduo Liu, Tao Wei, Bo Zhao, Shaojiong Zhou, Lei Liu, Yi Tang   +5 more
doaj   +1 more source

A systematic review of the role of TREM2 in Alzheimer’s disease

Chinese Medical Journal
. Background:. Given the established genetic linkage between triggering receptors expressed on myeloid cells 2 (TREM2) and Alzheimer’s disease (AD), an expanding research body has delved into the intricate role of TREM2 within the AD context. However, a
Yunsi Yin, Hanchen Yang, Ruiyang Li, Guangshan Wu, Qi Qin, Yi Tang, Ting Gao, Xiuyuan Hao   +7 more
doaj   +1 more source

Bulk regional viral injection in neonatal mice enables structural and functional interrogation of defined neuronal populations throughout targeted brain areas

Frontiers in Neural Circuits, 2015
The ability to label and manipulate specific cell types is central to understanding the structure and function of neuronal circuits. Here, we have developed a simple, affordable strategy for labeling of genetically-defined populations of neurons ...
Claire E J Cheetham, Claire E J Cheetham, Bryce D Grier, Leonardo eBelluscio   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source