Results 101 to 110 of about 4,670,463 (363)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Plasma platelet-derived growth factor receptor-β decrease correlates with blood-brain barrier damage in Alzheimer’s disease

Molecular Neurodegeneration
Background The blood-brain barrier (BBB) damage is frequently observed in Alzheimer’s disease (AD). However, it remains unclear whether plasma platelet-derived growth factor receptor-β (PDGFRβ) level is related to BBB damage and how it correlates with AD
Jieyin Li, Anqi Li, Chenghui Ye, Laihong Zhang, Mingxing Jiang, Guoyu Lan, Fernando Gonzalez-Ortiz, Jie Yang, Yalin Zhu, Yue Cai, Pan Sun, Lin Liu, Zhengbo He, Xin Zhou, Lili Fang, Yiying Wang, Zhen Liu, Kaj Blennow, Shaohua Ma, Xuhui Chen, Dai Shi, Tengfei Guo   +21 more
doaj   +1 more source

Modulation of functionally localized right insular cortex activity using real-time fMRI-based neurofeedback

Frontiers in Human Neuroscience, 2013
The capacity for subjects to learn to volitionally control localized brain activity using neurofeedback is actively being investigated. We aimed to investigate the ability of healthy volunteers to quickly learn to use visual feedback during real-time ...
Brian D Berman, Brian D Berman, Silvina G Horovitz, Mark eHallett   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Fecal Microbiota Transplantation in Neurological Disorders

Frontiers in Cellular and Infection Microbiology, 2020
Background: Several studies suggested an important role of the gut microbiota in the pathophysiology of neurological disorders, implying that alteration of the gut microbiota might serve as a treatment strategy.
K. Vendrik, R. Ooijevaar, Pieter R. de Jong, J. Laman, B. van Oosten, J. V. van Hilten, Q. R. Ducarmon, J. Keller, E. Kuijper, M. Contarino   +9 more
semanticscholar   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Causal relationships between type 1 diabetes mellitus and Alzheimer’s disease and Parkinson’s disease: a bidirectional two-sample Mendelian randomization study

European Journal of Medical Research
Background Previous compelling evidence suggests an association between Type 2 diabetes (T2D) and neurodegenerative diseases. However, it remains uncertain whether Type 1 diabetes mellitus (T1DM) exerts a causal influence on the risk of Alzheimer's ...
Chaofan Geng, Ke Meng, Bo Zhao, Xiaoduo Liu, Yi Tang   +4 more
doaj   +1 more source

DYSPHAGIA IN NEUROLOGICAL DISORDERS

Wiadomości Lekarskie, 2020
Introduction: Neurogenic dysphagia is a frequent disorder affecting people with neurological diseases. Many experts work together to diagnose and treat dysphagia. The aim: The article focuses on the specificity of neurogenic dysphagia, its symptoms and treatment possibilities.
Amelia, Śledzik, Paweł, Szlendak
openaire   +2 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

A multifactorial study on nutritional status, binge eating and physical activity as main factors directly influencing body weight in Parkinson’s disease

npj Parkinson's Disease, 2017
Weight lossisa multifactorial disorder commonly affecting Parkinson’s disease patients. The aim of this study was to investigate the relationship between body weight, nutritional status, physical activity, and Parkinson’s disease-related factors. A total
Andrea Bril, Santiago Perez-Lloret, Malco Rossi, Sofía Fariña, Pierre Morisset, Laura Sorrentino, Micaela Iglesias, Alex Medina Escobar, Patricio Millar Vernetti, Daniel Cerquetti, Marcelo Merello   +10 more
doaj   +1 more source