Results 21 to 30 of about 1,065,066 (238)

Development of a sensitive outcome for economical drug screening for progressive multiple sclerosis treatment

Frontiers in Neurology, 2016
Therapeutic advance in progressive multiple sclerosis (MS) has been very slow. Based on the transformative role magnetic resonance imaging (MRI) contrast-enhancing lesions had on drug development for relapsing-remitting MS, we consider the lack of ...
Peter Kosa, Danish Ghazali, Makoto Tanigawa, Chris Barbour, Irene Cortese, William Kelley, Blake Snyder, Joan Ohayon, Kaylan Fenton, Tanya Lehky, Tianxia Wu, Mark Greenwood, Govind Nair, Bibiana Bielekova   +13 more
doaj   +1 more source

Periictal water drinking revisited: Occurrence and lateralizing value in surgically confirmed patients with focal epilepsy

Epilepsia Open, 2023
Objective Periictal water drinking (PIWD), which is a rare seizure‐related autonomic behavior, has been reported in temporal lobe epilepsy (TLE) but only rarely in extra‐TLE. Additionally, the lateralizing value of PIWD is controversial.
Yuhei Tanno, Takashi Matsudaira, Naotaka Usui, Hiroshi Ogawa, Kentaro Tokumoto, Norihiko Kawaguchi, Akihiko Kondo, Takuji Nishida, Yukitoshi Takahashi   +8 more
doaj   +1 more source

DNA strand break repair and neurodegeneration. [PDF]

, 2013
A number of DNA repair disorders are known to cause neurological problems. These disorders can be broadly characterised into early developmental, mid-to-late developmental or progressive.
Abraham, Ahel, Alano, Alderton, Alter, Barbi, Barlow, Barnes, Bayatti, Bendixen, Bohr, Bootsma, Breslin, Brown, Buck, Buis, Caldecott, Caldecott, Caldecott, Cantoni, Chappell, Clements, Cortes Ledesma, Date, de Boer, de Boer, de Klein, de Vries, Delaval, Derheimer, Donahue, Durocher, El-Khamisy, El-Khamisy, El-Khamisy, Eliasson, Fattah, Frank, Frank, Frappart, Gao, Gao, Gatz, Goodship, Griffith, Gruber, Gueven, Henning, Hoeijmakers, Hoeijmakers, Jackson, Jeggo, Jilani, Kathe, Katyal, Keith W. Caldecott, Koch, Kuzminov, Lakin, Lakshmipathy, LaMonica, Le Ber, Lee, Lee, Lee, Lehmann, Letinic, Li, Licht, Lieber, Lindahl, Ljungman, Ljungman, Loizou, Luo, Mallery, Mao, Matsuura, Mayne, McKinnon, McKinnon, Mellon, Mischo, Mitchell, Moreira, Moreira, Moreno-Herrero, Morris, Moynahan, Mu, Murai, Murai, Murga, Nakane, Nance, Nilsen, Nussenzweig, Ogi, Okano, Orii, Osterod, Ouyang, O’Driscoll, O’Driscoll, O’Driscoll, Paula-Barbosa, Paull, Puebla-Osorio, Resnick, Revet, Reynolds, Reynolds, Rouse, Sanai, Schumacher, Shechter, Shen, Shiloh, Shull, Sidman, Skourti-Stathaki, Sleeth, Sonoda, Stefanini, Stewart, Stiff, Stuart L. Rulten, Sugasawa, Syljuasen, Takashima, Taylor, Tebbs, Theunissen, Thorslund, Uziel, van der Burg, van der Horst, Varon, Verhagen, Vinters, Virag, Vrouwe, Waltes, Weeda, Weterings, Whitehouse, Williams, Williams, Xu, Yu, Yu, Yuce, Zecevic, Zecevic, Zhou, Zhou, Zhu, Zou   +157 more
core   +1 more source

The associations between plasma soluble Trem1 and neurological diseases: a Mendelian randomization study

Journal of Neuroinflammation, 2022
Background Triggering receptor expressed on myeloid cell 1 (Trem1) is an important regulator of cellular inflammatory responses. Neuroinflammation is a common thread across various neurological diseases.
Xiaolei Shi, Tao Wei, Yachun Hu, Meng Wang, Yi Tang   +4 more
doaj   +1 more source

International Veterinary Epilepsy Task Force Consensus Proposal: Diagnostic approach to epilepsy in dogs [PDF]

, 2015
This article outlines the consensus proposal on diagnosis of epilepsy in dogs by the International Veterinary Epilepsy Task Force. The aim of this consensus proposal is to improve consistency in the diagnosis of epilepsy in the clinical and research ...
A Pákozdy, Akos Pakozdy, Andrea Fischer, Andrea Tipold, AT Berg, BG Licht, C Brauer, C Brauer, CL Mariani, Clare Rusbridge, EE Patterson, EE Patterson, G Urkasemsin, Heidrun Potschka, Holger A. Volk, J Guevar, Jacques Penderis, JJ Lin, JL Gill, JW Schmidley, Karen Muñana, Kaspar Matiasek, KJ Ekenstedt, L Arrol, LM Mellema, Luisa De Risio, M Armaşu, M Berendt, M Podell, M Schwartz, M Schwartz, M Wolf, Martí Pumarola Batlle, Mette Berendt, Michael Podell, N Shihab, Ned Patterson, O Devinsky, Paul JJ. Mandigers, PM Smith, R Edwards, R Erro, R Gonçalves, R Poma, R Zimmermann, RMA Packer, Robyn Farqhuar, Rowena MA Packer, RS Fisher, RS Fisher, S Shorvon, Sam Long, Simon Platt, Sofie Bhatti, TM Ghormle, V Hülsmeyer, Veronika Stein, WB Thomas, WW Bush, YC Huang   +59 more
core   +8 more sources

Peroxisomal disorders in neurology

Journal of the Neurological Sciences, 1988
Although peroxisomes were initially believed to play only a minor role in mammalian metabolism, it is now clear that they catalyse essential reactions in a number of different metabolic pathways and thus play an indispensable role in intermediary metabolism.
Wanders, R.J.A., Heymans, H.S.A., Schutgens, R.B.H., Barth, P.G., Bosch, H. van den, Tager, J.M.   +5 more
openaire   +4 more sources

Blood-brain barrier integrity of stroke patients presenting in an extended time window

BMC Neurology, 2020
Background Current guidelines limit thrombolytic treatment of stroke to those patients who present within 4.5 h to minimize the risk of hemorrhagic complications. Risk of hemorrhage increases with increasing blood-brain barrier (BBB) disruption.
Jarrhett Butler, Parisa Heidari, Sarah Blayney, Emi Hitomi, Marie Luby, Richard Leigh   +5 more
doaj   +1 more source

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

eLife, 2022
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the ...
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell   +8 more
doaj   +1 more source

Role of brain perfusion SPECT with 99mTc HMPAO in the assessment of response to drug therapy in patients with autoimmune vasculitis: a prospective study [PDF]

, 2015
BACKGROUND: The diagnosis of vasculitis in the brain remains a quite difficult achievement. To the best of our knowledge, there is no imaging method reported in literature which is capable of reaching to a diagnosis of vasculitis with very high ...
Anna Margherita Maffione, 2, Christos, Anagnostou, CIVITELLI, Liana, COLLORONE, SARA, DRUDI, Francesco Maria, FRANCIA, Ada, LIBERATORE, Mauro, Maria Cristina Marzola, 3, MEGNA, VALENTINA, MORREALE, MANUELA, Rubello, Domenico, Sotirios Chondrogiannis, 2   +11 more
core   +1 more source

Recent Advancement of Neurofibromatosis Type 1: A Narrative Review

Acta Neurologica Taiwanica
Neurofibromatosis type 1 (NF1) is a complex autosomal dominant genetic disorder caused by mutations in the NF1 gene on chromosome 17, which encodes the tumor-suppressor protein, neurofibromin.
Po-Yuan Huang, Society for Neurological Rare Disorders-Taiwan, Ming-Jen Lee   +2 more
doaj   +1 more source