Results 81 to 90 of about 1,108,914 (332)

Systemic T Cell Receptor Profiling Reveals Adaptive Immune Activation and Potential Immune Signatures of Diagnosis and Brain Atrophy in Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy is increasingly associated with immune dysregulation and inflammation. The T cell receptor (TCR), a key mediator of adaptive immunity, shows repertoire alterations in various immune‐mediated diseases. The unique TCR sequence serves as a molecular barcode for T cells, and clonal expansion accompanied by reduced overall TCR ...
Yong‐Won Shin, Sang Bin Hong, Yong Woo Shin, Inpyeong Hwang, Jaeseong Oh, Jihyeon Choi, Narae Kim, Jangsup Moon, Keun‐Hwa Jung, Kyung‐Il Park, Ki‐Young Jung, Kon Chu, Sang Kun Lee   +12 more
wiley   +1 more source

Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients

npj Parkinson's Disease
Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson’s disease (PD) and can be detected through synuclein amplification assays (SAA).
Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler   +17 more
doaj   +1 more source

Exploring evidence-based practice by occupational therapists when working with people with apraxia [PDF]

, 2008
Short Report Evidence in the literature supports a number of interventions that occupational therapists may utilise when working with people with apraxia, although there is no gold standard approach.
Roden, P, Tempest, S
core   +1 more source

Interleukin‐6 as a Key Biomarker in Facioscapulohumeral Dystrophy: Evidence From Longitudinal Analyses

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy type 1 (FSHD1) is a progressive neuromuscular disorder with no approved treatments. Identifying reliable biomarkers is critical to monitor disease severity, activity, and progression. Interleukin‐6 (IL‐6) has been proposed as a candidate biomarker, but longitudinal validation is limited ...
Jonathan Pini, Emanuela Martinuzzi, Sandra Dhifallah, Abderhmane Slioui, Angela Puma, Luisa Villa, Michele Cavalli, Andra Ezaru, Jérémy Garcia, Manuela Gambella, Federico Torre, Luca Jacopo Pavan, Nicolas Glaichenhaus, Sabrina Sacconi   +13 more
wiley   +1 more source

Biomarkers for immunotherapy for treatment of glioblastoma

Journal for ImmunoTherapy of Cancer, 2020
Immunotherapy is a promising new therapeutic field that has demonstrated significant benefits in many solid-tumor malignancies, such as metastatic melanoma and non-small cell lung cancer.
John P Lynes, Anthony K Nwankwo, Hannah P Sur, Victoria E Sanchez, Kwadwo A Sarpong, Oluwatobi I Ariyo, Gifty A Dominah, Edjah K Nduom   +7 more
doaj   +1 more source

Is Criminal Sentencing Influenced by Type of Disorder?

, 2019
Differences in sentencing due to disorder and gender were examined. Four scenarios were randomly presented for each disorder type. Participants indicated the sentence length for each scenario and whether they would parole the individual.
Jones, Tessa, Koch, Christopher
core  

Global, regional, and national burden of neurological disorders during 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 [PDF]

, 2016
Background Comparable data on the global and country-specific burden of neurological disorders and their trends are crucial for health-care planning and resource allocation.
Feigin, VL, Abajobir, AA, Abate, KH, Abd-Allah, F, Abdulle, AM, Abera, SF, Abyu, GY, Ahmed, MB, Aichour, AN, Aichour, I, Aichour, MTE, Akinyemi, RO, Alabed, S, Al-Raddadi, R, Alvis-Guzman, N, Amare, AT, Ansari, H, Anwari, P, Arnlov, J, Asayesh, H, Asgedom, SW, Atey, TM, Avila-Burgos, L, Avokpaho, EFGA, Azarpazhooh, MR, Barac, A, Barboza, M, Barker-Collo, SL, Baernighausen, T, Bedi, N, Beghi, E, Bennett, DA, Bensenor, IM, Berhane, A, Betsu, BD, Bhaumik, S, Birlik, SM, Biryukov, S, Boneya, DJ, Bulto, LN, Carabin, H, Casey, D, Castaneda-Orjuela, CA, Catala-Lopez, F, Chen, H, Chitheer, AA, Chowdhury, R, Christensen, H, Dandona, L, Dandona, R, deVeber, GA, Dharmaratne, SD, Huyen, PD, Dokova, K, Dorsey, ER, Ellenbogen, RG, Eskandarieh, S, Farvid, MS, Fereshtehnejad, S-M, Fischer, F, Foreman, KJ, Geleijnse, JM, Gillum, RF, Giussani, G, Goldberg, EM, Gona, PN, Goulart, AC, Gugnani, HC, Gupta, R, Gupta, R, Hachinski, V, Hamadeh, RR, Hambisa, M, Hankey, GJ, Hareri, HA, Havmoeller, R, Hay, SI, Heydarpour, P, Hotez, PJ, Jakovljevic, MMB, Javanbakht, M, Jeemon, P, Jonas, JB, Kalkonde, Y, Kandel, A, Karch, A, Kasaeian, A, Kastor, A, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, EA, Khang, Y-H, Khoja, AT, Khubchandani, J, Kulkarni, C, Kim, D, Kim, YJ, Kivimaki, M, Kokubo, Y, Kosen, S, Kravchenko, M, Krishnamurthi, RV, Defo, BK, Kumar, GA, Kumar, R, Kyu, HH, Larsson, A, Lavados, PM, Li, Y, Liang, X, Liben, ML, Lo, WD, Logroscino, G, Lotufo, PA, Loy, CT, Mackay, MT, Abd El Razek, HM, Abd El Razek, MM, Majeed, A, Malekzadeh, R, Manhertz, T, Mantovani, LG, Massano, J, Mazidi, M, McAlinden, C, Mehata, S, Mehndiratta, MM, Memish, ZA, Mendoza, W, Mengistie, MA, Mensah, GA, Meretoja, A, Mezgebe, HB, Miller, TR, Mishra, SR, Ibrahim, NM, Mohammadi, A, Mohammed, KE, Mohammed, S, Mokdad, AH, Moradi-Lakeh, M, Velasquez, IM, Musa, KI, Naghavi, M, Ngunjiri, JW, Cuong, TN, Nguyen, G, Quyen, LN, Trang, HN, Nichols, E, Ningrum, DN, Vuong, MN, Norrving, B, Noubiap, JJN, Ogbo, FA, Owolabi, MO, Pandian, JD, Parmar, PG, Pereira, DM, Petzold, M, Phillips, MR, Piradov, MA, Poulton, RG, Pourmalek, F, Qorbani, M, Rafay, A, Rahman, M, Rahman, MH, Rai, RK, Rajsic, S, Ranta, A, Rawaf, S, Renzaho, AMN, Rezai, MS, Roth, GA, Roshandel, G, Rubagotti, E, Sachdev, P, Safiri, S, Sahathevan, R, Sahraian, MA, Samy, AM, Santalucia, P, Santos, IS, Sartorius, B, Satpathy, M, Sawhney, M, Saylan, MI, Sepanlou, SG, Shaikh, MA, Shakir, R, Shamsizadeh, M, Sheth, KN, Shigematsu, M, Shoman, H, Silva, DA, Smith, M, Sobngwi, E, Sposato, LA, Stanaway, JD, Stein, DJ, Steiner, TJ, Stovner, LJ, Abdulkader, RS, Szoeke, CEI, Tabares-Seisdedos, R, Tanne, D, Theadom, AM, Thrift, AG, Tirschwell, DL, Topor-Madry, R, Bach, XT, Truelsen, T, Tuem, KB, Ukwaja, KN, Uthman, OA, Varakin, YY, Vasankari, T, Venketasubramanian, N, Vlassov, VV, Wadilo, F, Wakayo, T, Wallin, MT, Weiderpass, E, Westerman, R, Wijeratne, T, Wiysonge, CS, Woldu, MA, Wolfe, CDA, Xavier, D, Xu, G, Yano, Y, Yimam, HH, Yonemoto, N, Yu, C, Zaidi, Z, Zaki, MES, Zunt, JR, Murray, CJL, Vos, T   +240 more
core   +4 more sources

SNUPN‐Related Muscular Dystrophy: Novel Phenotypic, Pathological and Functional Protein Insights

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SNUPN‐related muscular dystrophy or LGMDR29 is a new entity that covers from a congenital or childhood onset pure muscular dystrophy to more complex phenotypes combining neurodevelopmental features, cataracts, or spinocerebellar ataxia. So far, 12 different variants have been described.
Nuria Muelas, Pablo Iruzubieta, Alberto Damborenea, Laura Pérez‐Fernández, Inmaculada Azorín, Juan Carlos Jiménez García, Ana Töpf, Pilar Martí, Lorena Fores‐Toribio, María Manterola, Rosana Blanco‐Mañez, Oihane Pikatza‐Menoio, Sonia Alonso‐Martín, Volker Straub, Aitziber L. Cortajarena, Adolfo López de Munain, David De Sancho, Lorea Blázquez, Juan J. Vilchez   +18 more
wiley   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog [PDF]

, 2014
Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM)
A Brodbelt, A Felbecker, AM Lidstrom, AM Lidstrom, AM Nilselid, B Szoor, C Sihlbom, C Wang, DR Averill, EM Schrijvers, FA Wininger, GB Cherubini, GD Shelton, H Reiber, H Satoh, H Tumani, Intan N. F. Shafie, IR Griffiths, Jacques Penderis, JR Coates, JW Harvey, K Al-Saktawi, K Sasaki, L Klimaschewski, M Calero, MA Stoodley, Mark McLaughlin, Mary Ann A. Lim, O Cordero-Llana, P Montague, P Narayan, PA March, Pamela E. J. Johnston, Paul Montague, PEJ Johnston, Richard Burchmore, RP Grewal, SE Jones, T Awano, Thomas J. Anderson   +39 more
core   +1 more source