Metformin as a potential therapeutic for neurological disease: mobilizing AMPK to repair the nervous system [PDF]
Expert Review of Neurotherapeutics, 2020 Introduction: Metformin is currently first line therapy for type 2 diabetes (T2D). The mechanism of action of metformin involves activation of AMP-activated protein kinase (AMPK) to enhance mitochondrial function (for example, biogenesis, refurbishment and dynamics) and autophagy.
Sarah Demaré +3 more
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Chaperone-Mediated Autophagy in Neurodegenerative Diseases and Acute Neurological Insults in the Central Nervous System [PDF]
Cells, 2022 Autophagy is an important function that mediates the degradation of intracellular proteins and organelles. Chaperone-mediated autophagy (CMA) degrades selected proteins and has a crucial role in cellular proteostasis under various physiological and pathological conditions.
Haruo Kanno +4 more
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Ecotoxicology and Environmental SafetyThis study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between ...
Fangyuan Cheng +4 more
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Air Pollution and Central Nervous System Disease: A Review of the Impact of Fine Particulate Matter on Neurological Disorders [PDF]
, 2020 Hyun‐Young Kim +3 more
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Optimizing filter trap assay for the detection of aggregated alpha-synuclein in brain samples
Free Neuropathology, 2020 Thibauld Oullier +5 more
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The Role and Mechanism of Metformin in the Treatment of Nervous System Diseases
BiomoleculesNervous system diseases represent a significant global burden, affecting approximately 16% of the world’s population and leading to disability and mortality.
Hui Li, Ruhui Liu, Junyan Liu, Yi Qu
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Charcot and vascular Parkinsonism
Arquivos de Neuro-PsiquiatriaJean-Martin Charcot (1825-1893), recognized as the founder of Neurology and the first formal teacher of nervous system diseases, died on August 16, 1893, from acute pulmonary edema secondary to myocardial infarction. In his last years, there were several
Hélio A. G. Teive +2 more
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Computational Neurosciences: a tool for clinical research about the brain [PDF]
Einstein (São Paulo), 2005 This review discusses fundamental concepts in computationalneuroscience and it presents applications of the computational modelconstruction in clinical problems in neurology and neuropsychology.The text presents basic processes involved in the ...
Marcelo Bastos Mazza
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Frontiers in Neural Circuits, 2019 Leukoaraiosis (LA) is associated with cognitive impairment in the older people which can be demonstrated in functional connectivity (FC) based on resting-state functional magnetic resonance imaging (rs-fMRI). This study is to explore the FC changes in LA
Hongyan Chen +30 more
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Effect of mechanical insufflation-exsufflation for ineffective cough on weaning duration in diseases of the peripheral or central nervous system (MEDINE): study protocol for a randomised controlled trial in a neurological weaning centre [PDF]
, 2023 Alexander Seipp +6 more
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